• 1. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 3. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 4. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
• 5. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416

Introduction to 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl-

The compound 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl-, with the CAS number 2248278-16-0, is a significant molecule in the field of organic chemistry. This compound belongs to the class of pyrimidine derivatives, which are widely studied due to their diverse applications in drug discovery and materials science. The structure of this compound features a pyrimidine ring with a carboxaldehyde group at position 2, a bromine substituent at position 4, and a methyl group at position 6. These substituents contribute to its unique chemical properties and reactivity.

Recent studies have highlighted the potential of pyrimidine derivatives in various therapeutic areas. For instance, researchers have explored the role of 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl- in targeting specific enzymes involved in cancer progression. The bromine substituent at position 4 has been shown to enhance the molecule's ability to inhibit certain kinases, making it a promising candidate for anti-cancer drug development. Additionally, the methyl group at position 6 contributes to the compound's stability and solubility, which are critical factors for its pharmacokinetic profile.

In terms of synthesis, the preparation of 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl- involves a multi-step process that typically includes nucleophilic substitution and alkylation reactions. The use of advanced catalytic systems has enabled chemists to achieve higher yields and better purity levels. Recent advancements in green chemistry have also led to the development of more sustainable methods for synthesizing this compound, reducing its environmental footprint.

The application of 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl- extends beyond pharmaceuticals. It has been utilized in the synthesis of advanced materials, such as coordination polymers and metal-organic frameworks (MOFs). The carboxaldehyde group serves as a versatile binding site for metal ions, enabling the construction of highly porous and functional materials with applications in gas storage and catalysis.

From an analytical standpoint, modern techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry have been employed to characterize this compound with high precision. These methods have provided insights into its molecular structure and dynamic behavior under various conditions. Furthermore, computational chemistry tools have been used to predict the electronic properties and reactivity of 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl-, aiding in its rational design for specific applications.

In conclusion, 2-Pyrimidinecarboxaldehyde, 4-Bromo-6-Methyl- is a versatile compound with significant potential in multiple fields. Its unique structure and functional groups make it an attractive target for both academic research and industrial applications. As ongoing studies continue to uncover new aspects of its chemistry and biology, this compound is poised to play an increasingly important role in advancing scientific knowledge and technological innovation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)