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Comprehensive Overview of 1-Methyl-4-(pyridin-3-yl)piperazine (CAS No. 223794-26-1): Properties, Applications, and Research Insights

1-Methyl-4-(pyridin-3-yl)piperazine (CAS No. 223794-26-1) is a heterocyclic organic compound gaining significant attention in pharmaceutical and chemical research due to its versatile structural framework. The molecule combines a piperazine ring with a pyridine substituent, making it a valuable intermediate for drug discovery and material science. Researchers and industry professionals frequently search for terms like "1-methyl-4-(pyridin-3-yl)piperazine synthesis", "CAS 223794-26-1 applications", and "pyridine-piperazine derivatives", reflecting its growing relevance in modern chemistry.

The compound's unique structure enables interactions with biological targets, particularly in central nervous system (CNS) research. Recent studies highlight its potential as a precursor for neuromodulators and receptor ligands, aligning with trends in neuropharmacology and precision medicine. Its solubility in polar solvents and thermal stability (up to 200°C) further broaden its utility in high-throughput screening and catalysis. Questions like "How to purify 1-methyl-4-(pyridin-3-yl)piperazine?" or "Is CAS 223794-26-1 biodegradable?" are common among environmental chemists, emphasizing the need for sustainable synthesis protocols.

In material science, 1-methyl-4-(pyridin-3-yl)piperazine serves as a building block for coordination polymers and metal-organic frameworks (MOFs). Its chelating properties allow for the design of functional materials with applications in gas storage and molecular sensing. The compound's crystallographic data (monoclinic system, P2₁/c space group) is often cited in crystallography forums, addressing queries such as "X-ray diffraction patterns of CAS 223794-26-1".

From a regulatory perspective, 1-methyl-4-(pyridin-3-yl)piperazine is classified as a non-hazardous substance under standard conditions, though proper laboratory safety protocols (e.g., glovebox use for hygroscopic samples) are recommended. Analytical techniques like HPLC (retention time ~6.2 min under reverse-phase conditions) and NMR spectroscopy (¹H NMR δ 2.3 ppm for N-methyl protons) are critical for quality control, as noted in searches for "CAS 223794-26-1 characterization methods".

Emerging applications include its role in photoredox catalysis and electrochemical sensors, where its redox-active pyridine moiety enhances electron transfer efficiency. With the rise of green chemistry, researchers explore microwave-assisted synthesis of this compound to reduce energy consumption. Patent databases reveal growing interest in 1-methyl-4-(pyridin-3-yl)piperazine derivatives for optoelectronic devices, responding to demands for organic semiconductors in flexible electronics.

The compound's structure-activity relationship (SAR) is frequently discussed in medicinal chemistry circles, particularly regarding bioisosteric replacements for lead optimization. Computational chemists employ molecular docking studies to predict its binding affinity with dopamine receptors, addressing search terms like "CAS 223794-26-1 docking scores". Recent publications also investigate its metabolic pathways using LC-MS techniques, crucial for ADME/Tox profiling in drug development.

Industrial-scale production of 1-methyl-4-(pyridin-3-yl)piperazine requires optimization of atom economy and catalyst recycling, topics dominating process chemistry symposia. The compound's logP value (~1.8) makes it suitable for blood-brain barrier penetration studies, explaining frequent queries about "lipophilicity of CAS 223794-26-1". As AI-assisted drug design advances, this molecule's scaffold diversity positions it as a key candidate for virtual screening libraries.

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