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• Catalysts and Inorganic Chemicals Inorganic Compounds Homogeneous non-metal compounds Homogeneous other non-metal compounds

Introduction to Bicyclo[2.2.1]heptane-2-carbonitrile (CAS No: 2234-26-6)

Bicyclo[2.2.1]heptane-2-carbonitrile, identified by its Chemical Abstracts Service (CAS) number 2234-26-6, is a significant heterocyclic compound that has garnered considerable attention in the field of organic synthesis and pharmaceutical research. This bicyclic structure, characterized by its fused three-membered and five-membered rings, presents a unique framework that is highly versatile for the development of novel chemical entities. The presence of a nitrile group at the 2-position introduces additional reactivity, making it a valuable intermediate in the synthesis of more complex molecules.

The molecular architecture of Bicyclo[2.2.1]heptane-2-carbonitrile contributes to its remarkable chemical properties, which include moderate stability under various reaction conditions and the ability to undergo diverse transformations such as nucleophilic additions, reductions, and cyclizations. These attributes have positioned it as a cornerstone in the synthesis of pharmacologically relevant compounds, particularly in the development of central nervous system (CNS) drugs, where its rigid bicyclic core can mimic natural bioactive scaffolds.

In recent years, advancements in synthetic methodologies have enabled more efficient access to derivatives of Bicyclo[2.2.1]heptane-2-carbonitrile, fostering its application in medicinal chemistry. For instance, researchers have leveraged transition-metal-catalyzed reactions to introduce functional groups at specific positions within the molecule, thereby expanding its synthetic utility. These developments have been instrumental in designing molecules with enhanced binding affinity and selectivity for therapeutic targets.

One of the most compelling aspects of Bicyclo[2.2.1]heptane-2-carbonitrile is its role as a precursor in the synthesis of bioactive heterocycles that exhibit promising pharmacological activities. Studies have demonstrated its utility in generating compounds with potential applications in treating neurological disorders, including epilepsy and depression. The nitrile functionality serves as a versatile handle for further derivatization, allowing chemists to fine-tune physicochemical properties such as solubility and metabolic stability.

Recent research has also highlighted the importance of Bicyclo[2.2.1]heptane-2-carbonitrile in the development of kinase inhibitors, which are critical for targeting various cancers and inflammatory diseases. By incorporating this scaffold into drug candidates, scientists have been able to achieve high binding affinity to protein kinases while minimizing off-target effects. The rigid bicyclic core provides structural constraints that enhance ligand efficiency, making it an attractive choice for drug design.

The synthesis of Bicyclo[2.2.1]heptane-2-carbonitrile itself has seen significant progress, with reports describing streamlined routes that improve yield and scalability. These methodologies often involve cycloaddition reactions or intramolecular cyclizations, which are highly complementary to modern synthetic strategies. Such improvements have not only facilitated academic research but also paved the way for industrial applications where cost-effective production is paramount.

Another area where Bicyclo[2.2.1]heptane-2-carbonitrile has made an impact is in materials science, particularly in the design of liquid crystals and polymers with unique structural properties. The compound's ability to adopt multiple conformations due to its rigid framework makes it an excellent candidate for creating materials with tailored optical and electronic characteristics.

In conclusion, Bicyclo[2.2.1]heptane-2-carbonitrile (CAS No: 2234-26-6) represents a multifaceted compound with broad applications across multiple scientific disciplines. Its unique structural features and reactivity profile continue to drive innovation in pharmaceuticals, materials science, and organic chemistry. As research progresses, it is anticipated that new derivatives and applications will emerge, further solidifying its importance in the chemical community.

• 73037-35-1(4,7-Methano-1H-indenecarbonitrile,octahydro-)
• 3211-90-3(Bicyclo[2.2.1]heptane-2-carbonitrile,(1R,2R,4S)-rel-)
• 102504-62-1(Bicyclo[2.2.1]heptane-2-propanenitrile,3-cyano-)
• 61757-82-2(Bicyclo[2.2.1]heptane-2,6-dicarbonitrile, 2-(2-cyanoethyl)-)
• 61757-74-2(Bicyclo[2.2.1]heptane-2,5-dicarbonitrile, 3-(2-cyanoethyl)-)
• 302780-17-2(Bicyclo[2.2.1]heptane-2-carbonitrile,3,6-dimethyl-)
• 61757-75-3(Bicyclo[2.2.1]heptane-2,6-dicarbonitrile, 3-(2-cyanoethyl)-)
• 3211-87-8(Bicyclo[2.2.1]heptane-2-carbonitrile,(1R,2S,4S)-rel-)
• 104516-98-5(Bicyclo[2.2.1]heptane-2-carbonitrile,3,5-dimethyl-)
• 61757-81-1(Bicyclo[2.2.1]heptane-2,5-dicarbonitrile, 2-(2-cyanoethyl)-)