Cas no 2229258-86-8 (2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol)
2,2-Difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol is a fluorinated indole derivative with potential applications in medicinal chemistry and pharmaceutical research. The presence of difluoromethyl and hydroxyl groups enhances its reactivity, making it a versatile intermediate for synthesizing biologically active compounds. Its indole core is structurally significant, often associated with interactions in receptor binding and enzyme inhibition. The difluoro substitution may improve metabolic stability and bioavailability compared to non-fluorinated analogs. This compound is particularly useful in the development of novel therapeutic agents, including kinase inhibitors and CNS-targeted drugs. Its well-defined structure allows for precise modifications, supporting structure-activity relationship (SAR) studies in drug discovery.
2229258-86-8 structure
Product Name:2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol
CAS No:2229258-86-8
MF:C11H11F2NO
MW:211.207949876785
CID:5850192
PubChem ID:165653135
Update Time:2025-06-07
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol Chemical and Physical Properties
Names and Identifiers
-
- 2229258-86-8
- EN300-1668812
- 2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol
-
- Inchi: 1S/C11H11F2NO/c1-14-5-4-7-2-3-8(6-9(7)14)10(15)11(12)13/h2-6,10-11,15H,1H3
- InChI Key: IUEYQDCTHHUWKQ-UHFFFAOYSA-N
- SMILES: FC(C(C1C=CC2C=CN(C)C=2C=1)O)F
Computed Properties
- Exact Mass: 211.08087030g/mol
- Monoisotopic Mass: 211.08087030g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 15
- Rotatable Bond Count: 2
- Complexity: 225
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2
- Topological Polar Surface Area: 25.2?2
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Enamine | EN300-1668812-0.05g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 0.05g |
$660.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-0.1g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 0.1g |
$691.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-0.25g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 0.25g |
$723.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-0.5g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 0.5g |
$754.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-1.0g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 1g |
$785.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-2.5g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 2.5g |
$1539.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-5.0g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 5g |
$2277.0 | 2023-06-04 | ||
| Enamine | EN300-1668812-10.0g |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol |
2229258-86-8 | 10g |
$3376.0 | 2023-06-04 |
2,2-difluoro-1-(1-methyl-1H-indol-6-yl)ethan-1-ol Related Literature
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Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
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Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
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Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
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Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
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Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
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