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Comprehensive Guide to 1-(6-Methoxypyridin-2-yl)cyclopropylmethanol (CAS No. 2228561-45-1): Properties, Applications, and Market Insights

1-(6-Methoxypyridin-2-yl)cyclopropylmethanol (CAS No. 2228561-45-1) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique cyclopropylmethanol moiety and 6-methoxypyridine ring, serves as a versatile intermediate in the synthesis of bioactive molecules. Its molecular structure combines the stability of a cyclopropyl group with the reactivity of a methanol derivative, making it valuable for drug discovery and material science applications.

The growing demand for pyridine-based compounds in medicinal chemistry has propelled research into derivatives like 1-(6-Methoxypyridin-2-yl)cyclopropylmethanol. Researchers are particularly interested in its potential as a building block for kinase inhibitors and G-protein-coupled receptor (GPCR) modulators, which are pivotal in treating cancers and neurological disorders. Recent studies highlight its role in optimizing drug bioavailability and metabolic stability, addressing key challenges in modern pharmacology.

From a synthetic perspective, 1-(6-Methoxypyridin-2-yl)cyclopropylmethanol is synthesized via Grignard reactions or cyclopropanation techniques, often involving 2-bromo-6-methoxypyridine as a starting material. Its methoxy group enhances electron density, facilitating further functionalization—a feature exploited in designing heterocyclic scaffolds for agrochemicals like neonicotinoid alternatives, a hot topic due to environmental concerns over traditional pesticides.

Market trends indicate rising investments in high-value chemical intermediates, with CAS No. 2228561-45-1 benefiting from its niche applications. The compound aligns with the green chemistry movement, as its derivatives show promise in biodegradable agrochemical formulations. Analysts project growth in its use for crop protection chemicals, driven by global food security demands and stricter environmental regulations.

In material science, the rigid cyclopropyl structure of this compound contributes to the development of advanced polymers with enhanced thermal stability. Innovations in OLED materials and liquid crystals also explore its derivatives, capitalizing on the electron-rich pyridine ring for optoelectronic applications. Such interdisciplinary relevance makes it a frequent subject in patent filings and academic publications.

For researchers sourcing 1-(6-Methoxypyridin-2-yl)cyclopropylmethanol, purity (>98%) and regioselective synthesis protocols are critical considerations. Suppliers often provide custom synthesis services to meet specific structure-activity relationship (SAR) study requirements. Storage recommendations typically emphasize protection from moisture-sensitive degradation, given the hydroxyl group’s reactivity.

Emerging applications include its use in proteolysis-targeting chimeras (PROTACs), a breakthrough technology in targeted protein degradation. The compound’s ability to integrate into bifunctional linker systems positions it at the forefront of next-generation therapeutics. This aligns with trending searches for "small molecules in targeted therapy" and "sustainable chemical intermediates", reflecting industry priorities.

Regulatory-wise, CAS 2228561-45-1 complies with major chemical inventories (e.g., REACH, TSCA), though users should verify country-specific compliance for specialized applications. Analytical methods like HPLC-MS and NMR spectroscopy are standard for quality control, ensuring batch-to-batch consistency—a key concern for GMP manufacturing in pharmaceuticals.

In conclusion, 1-(6-Methoxypyridin-2-yl)cyclopropylmethanol exemplifies the convergence of medicinal chemistry, sustainable agriculture, and advanced materials. Its multifaceted utility and alignment with industry megatrends ensure continued relevance, making it a compound to watch in both academic and industrial settings. Future research may unlock further potential in catalysis and bioorthogonal chemistry, expanding its already diverse applications.

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