Cas no 2228405-92-1 (3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol)

3-(2-Chloro-1,3-thiazol-5-yl)propan-1-ol is a versatile intermediate in organic synthesis, particularly valued for its functional thiazole core and hydroxyl-terminated alkyl chain. The chloro-substituted thiazole moiety enhances reactivity, making it useful in cross-coupling reactions and as a precursor for agrochemicals and pharmaceuticals. The propanol side chain provides additional flexibility for further derivatization, enabling applications in fine chemical synthesis. Its well-defined structure ensures consistent performance in multi-step synthetic routes. This compound is particularly relevant in the development of bioactive molecules, where the thiazole ring contributes to enhanced binding properties. High purity and stability under standard conditions further support its utility in research and industrial processes.
3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol structure
2228405-92-1 structure
Product Name:3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol
CAS No:2228405-92-1
MF:C6H8ClNOS
MW:177.651819229126
CID:5787648
PubChem ID:133055082
Update Time:2025-11-02

3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol Chemical and Physical Properties

Names and Identifiers

    • 2228405-92-1
    • 3-(2-Chlorothiazol-5-yl)propan-1-ol
    • EN300-1995260
    • 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol
    • Inchi: 1S/C6H8ClNOS/c7-6-8-4-5(10-6)2-1-3-9/h4,9H,1-3H2
    • InChI Key: GYMNPNKWYGBECL-UHFFFAOYSA-N
    • SMILES: ClC1=NC=C(CCCO)S1

Computed Properties

  • Exact Mass: 177.0015127g/mol
  • Monoisotopic Mass: 177.0015127g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 3
  • Complexity: 104
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.9
  • Topological Polar Surface Area: 61.4?2

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Additional information on 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol

Comprehensive Overview of 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol (CAS No. 2228405-92-1)

3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol (CAS No. 2228405-92-1) is a specialized organic compound that has garnered significant attention in recent years due to its unique structural features and potential applications in various industries. This compound belongs to the thiazole derivatives family, which are known for their diverse biological activities and industrial uses. The presence of both chloro and hydroxy functional groups in its molecular structure makes it a versatile intermediate in organic synthesis.

The chemical structure of 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol consists of a thiazole ring substituted with a chlorine atom at the 2-position and a propanol side chain at the 5-position. This arrangement imparts distinct physicochemical properties, including moderate polarity and good solubility in common organic solvents. Researchers have been particularly interested in this compound's potential as a building block for pharmaceutical intermediates and agrochemical formulations, aligning with current trends in drug discovery and sustainable agriculture.

Recent studies have explored the synthetic applications of CAS 2228405-92-1 in developing novel heterocyclic compounds, which are increasingly important in medicinal chemistry. The compound's thiazole moiety is particularly valuable as it appears in many biologically active molecules, addressing the growing demand for new therapeutic agents. This relevance to drug development makes 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol a subject of interest in pharmaceutical research circles.

From a commercial perspective, the market for thiazole derivatives like 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol has shown steady growth, driven by increasing R&D activities in life sciences. Manufacturers and suppliers are responding to frequent inquiries about high-purity thiazole compounds, reflecting the compound's importance in modern chemical synthesis. The global focus on green chemistry has also influenced production methods for such intermediates, with many companies now offering environmentally friendly synthesis routes.

Analytical characterization of 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol typically involves advanced techniques such as HPLC, GC-MS, and NMR spectroscopy, ensuring precise quality control for research and industrial applications. These analytical methods are crucial for verifying the compound's purity, especially when used as a precursor in sensitive chemical processes. The availability of detailed spectral data for this compound has facilitated its adoption in various laboratory settings.

Storage and handling recommendations for CAS 2228405-92-1 follow standard protocols for organic compounds, with emphasis on protection from moisture and extreme temperatures. While not classified as hazardous under normal conditions, proper laboratory practices should be maintained when working with this chemical. The compound's stability profile makes it suitable for long-term storage when kept in appropriate conditions, an important consideration for inventory management in research facilities.

Innovative applications of 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol continue to emerge, particularly in the development of functional materials and specialty chemicals. Its structural features allow for various chemical modifications, making it a valuable tool for materials scientists exploring new polymer systems or advanced coatings. This versatility aligns well with current industry trends toward multifunctional additives and performance chemicals.

The synthesis of 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol typically involves multi-step organic reactions starting from commercially available thiazole precursors. Recent process optimization efforts have focused on improving yields and reducing byproducts, reflecting the chemical industry's commitment to sustainable manufacturing. These advancements have made the compound more accessible to researchers while maintaining competitive pricing in the specialty chemicals market.

Regulatory aspects concerning CAS 2228405-92-1 vary by region, but the compound generally falls under standard chemical regulations rather than specific controlled substance categories. Manufacturers and users should consult current chemical compliance guidelines to ensure proper documentation and handling procedures. The compound's status as a research chemical rather than a commercial product in most jurisdictions simplifies its procurement for legitimate scientific purposes.

Future prospects for 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol appear promising, with potential expansions into new application areas such as electronic materials and catalysis. The growing interest in nitrogen-containing heterocycles across multiple scientific disciplines suggests sustained demand for this and related compounds. Ongoing research may uncover additional uses that further enhance the value of this versatile chemical building block.

For researchers seeking detailed technical information about 3-(2-chloro-1,3-thiazol-5-yl)propan-1-ol, comprehensive safety data sheets and technical bulletins are available from reputable chemical suppliers. These documents provide essential data on physical properties, handling precautions, and storage recommendations, facilitating safe and effective use of the compound in various experimental settings.

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