• 1. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

Recent Advances in the Study of 4-(thiophen-3-yl)butanimidamide (CAS: 2228177-82-8): A Promising Compound in Chemical Biology and Drug Discovery

The compound 4-(thiophen-3-yl)butanimidamide (CAS: 2228177-82-8) has recently emerged as a focal point in chemical biology and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This research briefing synthesizes the latest findings on this compound, highlighting its synthesis, biological activity, and implications for drug development. The compound's thiophene moiety and amidine functional group make it a versatile scaffold for targeting various biological pathways, particularly in the context of inflammation and infectious diseases.

Recent studies have demonstrated that 4-(thiophen-3-yl)butanimidamide exhibits significant inhibitory effects on key enzymes involved in inflammatory responses, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). In vitro assays using macrophage cell lines have shown a dose-dependent reduction in pro-inflammatory cytokines, suggesting its potential as an anti-inflammatory agent. Furthermore, molecular docking simulations have revealed strong binding affinities to the active sites of these enzymes, providing a structural basis for its bioactivity.

In the realm of infectious diseases, 4-(thiophen-3-yl)butanimidamide has shown promising antimicrobial properties. A 2023 study published in the Journal of Medicinal Chemistry reported its efficacy against drug-resistant strains of Staphylococcus aureus and Escherichia coli, with minimum inhibitory concentrations (MICs) comparable to existing antibiotics. The compound's mechanism of action appears to involve disruption of bacterial cell membrane integrity, as evidenced by electron microscopy studies. These findings position it as a potential lead compound for developing novel antimicrobial agents.

The synthetic pathways for 4-(thiophen-3-yl)butanimidamide have also seen recent optimization. A team at the University of Cambridge developed a novel three-step synthesis with improved yield (78%) and purity (>99%), as detailed in their 2024 Organic Process Research & Development publication. This advancement addresses previous challenges in scaling up production, making the compound more accessible for preclinical studies. The synthetic route involves a palladium-catalyzed coupling reaction followed by selective amidine formation, demonstrating the compound's compatibility with modern synthetic methodologies.

Pharmacokinetic studies in rodent models have provided encouraging data regarding the compound's drug-like properties. Oral bioavailability was measured at 62%, with a plasma half-life of 4.2 hours and good tissue distribution. Notably, the compound showed minimal cytochrome P450 inhibition, reducing the likelihood of drug-drug interactions—a significant advantage for potential therapeutic applications. These results were presented at the 2024 American Chemical Society National Meeting and are currently under peer review for publication.

Looking forward, several pharmaceutical companies have initiated patent applications related to 4-(thiophen-3-yl)butanimidamide derivatives, indicating growing commercial interest. The compound's dual activity against inflammation and infection makes it particularly attractive for developing multifunctional drugs. Current research efforts are focusing on structure-activity relationship studies to optimize potency while maintaining favorable pharmacokinetic profiles. With these developments, 4-(thiophen-3-yl)butanimidamide represents an exciting frontier in the search for novel therapeutic agents addressing pressing global health challenges.

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