Cas no 22280-56-4 (2-chloro-3-methyl-5-nitro-pyridine)

2-Chloro-3-methyl-5-nitropyridine is a versatile heterocyclic compound widely used as a key intermediate in pharmaceutical and agrochemical synthesis. Its molecular structure, featuring a chloro group at the 2-position, a methyl group at the 3-position, and a nitro group at the 5-position, provides multiple reactive sites for further functionalization. This compound exhibits high chemical stability and reactivity, making it suitable for nucleophilic substitution and coupling reactions. It is particularly valuable in the development of active pharmaceutical ingredients (APIs) and crop protection agents. The nitro group enhances its electrophilic properties, facilitating various reduction and condensation reactions. Its well-defined purity and consistent quality ensure reliable performance in synthetic applications.
2-chloro-3-methyl-5-nitro-pyridine structure
22280-56-4 structure
Product Name:2-chloro-3-methyl-5-nitro-pyridine
CAS No:22280-56-4
MF:C6H5ClN2O2
MW:172.569100141525
MDL:MFCD00173686
CID:52020
PubChem ID:87558591
Update Time:2025-07-02

2-chloro-3-methyl-5-nitro-pyridine Chemical and Physical Properties

Names and Identifiers

    • 2-Chloro-3-methyl-5-nitropyridine
    • 2-CHLORO-5-NITRO-3-PICOLINE
    • 2-Chlor-3-methyl-5-nitro-pyridin
    • 2-chloro-5-nitro-3-methylpyridine
    • 3-methyl-5-nitro-2-chloropyridine
    • 6-chloro-5-methyl-3-nitropyridine
    • Pyridine,2-chloro-3-methyl-5-nitro
    • Pyridine, 2-chloro-3-methyl-5-nitro-
    • 2-Chloro-3-methyl-5-Nitro pyridine
    • 2-chloro-3-methyl-5-nitro-pyridine
    • 2-Chloro-5-nitro-3-picoline (2-Chloro-3-methyl-5-nitropyridine)
    • NSC63887
    • PubChem10621
    • KSC207A2N
    • PYR178
    • Jsp004528
    • OSIOIGXJUZTWRI-UHFFFAOYSA-
    • OSIOI
    • 2-Chloro-3-methyl-5nitropyridine
    • AM20050960
    • AKOS005064142
    • SY004411
    • 2-Chloro-3-methyl-5-nitropyridine, 97%
    • MFCD00173686
    • AC-10878
    • PB25986
    • HY-32796
    • A4785
    • NS00027118
    • OSIOIGXJUZTWRI-UHFFFAOYSA-N
    • BCP22226
    • NSC-63887
    • W-206744
    • 45ZN7UCB3M
    • NSC 63887
    • CS-D0963
    • PS-4180
    • SB20915
    • C2020
    • EN300-63950
    • DTXSID70176827
    • UNII-45ZN7UCB3M
    • Z991524294
    • 22280-56-4
    • 2-chloro-3-methyl -5-nitro-pyridine
    • EINECS 244-889-5
    • InChI=1/C6H5ClN2O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3
    • FT-0611730
    • SCHEMBL801244
    • DTXCID0099318
    • STL555675
    • BBL101878
    • DB-025117
    • MDL： MFCD00173686
    • Inchi： 1S/C6H5ClN2O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3
    • InChI Key： OSIOIGXJUZTWRI-UHFFFAOYSA-N
    • SMILES： ClC1C(C)=CC(=CN=1)[N+](=O)[O-]

Computed Properties

  • Exact Mass: 172.00400
  • Monoisotopic Mass: 172.004
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 0
  • Complexity: 159
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2
  • Topological Polar Surface Area: 58.7

Experimental Properties

  • Color/Form: Undetermined 2. density (g/ml, 25/4 ℃)
  • Density: 1.5610 (rough estimate)
  • Melting Point: 47.0 to 51.0 deg-C
  • Boiling Point: 145°C/18mmHg(lit.)
  • Flash Point: Degrees Fahrenheit:>230°F
    Degrees Celsius:>110°C
  • Refractive Index: 1.5500 (estimate)
  • PSA: 58.71000
  • LogP: 2.47480
  • Sensitiveness: Hygroscopic

2-chloro-3-methyl-5-nitro-pyridine Security Information

  • Symbol: GHS05 GHS06
  • Prompt：warning
  • Signal Word：Danger
  • Hazard Statement： H301,H315,H318,H335
  • Warning Statement： P261,P280,P301+P310,P305+P351+P338
  • Hazardous Material transportation number：UN 2811 6.1 / PGIII
  • WGK Germany：3
  • Hazard Category Code： 22-37/38-41
  • Safety Instruction： S37/39-S26
  • Hazardous Material Identification： Xn
  • HazardClass：IRRITANT
  • Storage Condition：2-8°C
  • Safety Term：S26;S37/39
  • Risk Phrases：R20/21/22; R36/37/38

2-chloro-3-methyl-5-nitro-pyridine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-chloro-3-methyl-5-nitro-pyridine Production Method

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