Cas no 2227884-60-6 (rac-(1R,3R)-3-2-(4-fluorophenyl)ethyl-2,2-dimethylcyclopropane-1-carboxylic acid)
Technical Introduction:
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid is a chiral cyclopropane derivative featuring a fluorophenyl substituent, which imparts unique steric and electronic properties. The cyclopropane ring’s rigidity and the fluorine atom’s inductive effects enhance its potential as an intermediate in pharmaceutical synthesis, particularly for bioactive molecules requiring precise stereochemistry. The compound’s structural stability and defined stereocenters make it valuable for applications in asymmetric synthesis and medicinal chemistry research. Its well-characterized configuration ensures reproducibility in studies targeting receptor interactions or metabolic pathways. This compound is suited for use in high-precision synthetic routes where regio- and stereoselectivity are critical.
2227884-60-6 structure
Product Name:rac-(1R,3R)-3-2-(4-fluorophenyl)ethyl-2,2-dimethylcyclopropane-1-carboxylic acid
CAS No:2227884-60-6
MF:C14H17FO2
MW:236.281987905502
CID:5570402
PubChem ID:165641521
Update Time:2025-06-07
rac-(1R,3R)-3-2-(4-fluorophenyl)ethyl-2,2-dimethylcyclopropane-1-carboxylic acid Chemical and Physical Properties
Names and Identifiers
-
- EN300-1781068
- rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid
- 2227884-60-6
- rac-(1R,3R)-3-2-(4-fluorophenyl)ethyl-2,2-dimethylcyclopropane-1-carboxylic acid
-
- Inchi： 1S/C14H17FO2/c1-14(2)11(12(14)13(16)17)8-5-9-3-6-10(15)7-4-9/h3-4,6-7,11-12H,5,8H2,1-2H3,(H,16,17)/t11-,12+/m0/s1
- InChI Key： CXOQVCWNMRWKSE-NWDGAFQWSA-N
- SMILES： FC1C=CC(=CC=1)CC[C@H]1[C@H](C(=O)O)C1(C)C
Computed Properties
- Exact Mass: 236.12125794g/mol
- Monoisotopic Mass: 236.12125794g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 17
- Rotatable Bond Count: 4
- Complexity: 293
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.6
- Topological Polar Surface Area: 37.3?2
rac-(1R,3R)-3-2-(4-fluorophenyl)ethyl-2,2-dimethylcyclopropane-1-carboxylic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Enamine | EN300-1781068-0.05g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 0.05g |
$1056.0 | 2023-09-20 | ||
| Enamine | EN300-1781068-0.1g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 0.1g |
$1106.0 | 2023-09-20 | ||
| Enamine | EN300-1781068-0.25g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 0.25g |
$1156.0 | 2023-09-20 | ||
| Enamine | EN300-1781068-0.5g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 0.5g |
$1207.0 | 2023-09-20 | ||
| Enamine | EN300-1781068-1.0g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 1.0g |
$1256.0 | 2023-07-10 | ||
| Enamine | EN300-1781068-2.5g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 2.5g |
$2464.0 | 2023-09-20 | ||
| Enamine | EN300-1781068-5.0g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 5.0g |
$3645.0 | 2023-07-10 | ||
| Enamine | EN300-1781068-10.0g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 10.0g |
$5405.0 | 2023-07-10 | ||
| Enamine | EN300-1781068-1g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 1g |
$1256.0 | 2023-09-20 | ||
| Enamine | EN300-1781068-5g |
rac-(1R,3R)-3-[2-(4-fluorophenyl)ethyl]-2,2-dimethylcyclopropane-1-carboxylic acid |
2227884-60-6 | 5g |
$3645.0 | 2023-09-20 |
rac-(1R,3R)-3-2-(4-fluorophenyl)ethyl-2,2-dimethylcyclopropane-1-carboxylic acid Related Literature
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Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
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2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
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Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
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Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
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Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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