• 1. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 2. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 4. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 5. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966

Comprehensive Guide to (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol (CAS No. 2227723-37-5): Properties, Applications, and Market Insights

(2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol (CAS No. 2227723-37-5) is a specialized chiral compound that has garnered significant attention in pharmaceutical and chemical research. This fluorinated nitroaromatic alcohol is characterized by its unique stereochemistry and functional groups, making it a valuable intermediate in organic synthesis. The compound's molecular structure features a 2-fluoro-3-nitrophenyl moiety attached to a propan-2-ol backbone, with the (2S) configuration imparting distinct reactivity and biological activity.

In recent years, the demand for chiral building blocks like (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol has surged due to their critical role in asymmetric synthesis. Researchers are particularly interested in how the fluoro and nitro substituents influence the compound's electronic properties and interactions with biological targets. The CAS 2227723-37-5 compound has shown promise in medicinal chemistry applications, where its structural features can be leveraged to develop novel therapeutic agents.

The synthesis of (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol typically involves multi-step organic transformations, including selective fluorination and nitration reactions. Recent advances in green chemistry have led to more sustainable production methods for such compounds, addressing growing environmental concerns in the chemical industry. Many researchers are exploring enzymatic approaches or catalytic systems to improve the stereoselectivity and yield of this valuable intermediate.

From an analytical perspective, CAS 2227723-37-5 presents interesting challenges and opportunities. Modern techniques like HPLC with chiral columns and NMR spectroscopy are essential for characterizing the compound's purity and stereochemical integrity. The presence of both electron-withdrawing groups (fluoro and nitro) creates unique spectroscopic signatures that aid in structural confirmation and quality control.

The pharmaceutical applications of (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol are particularly noteworthy. As the industry shifts toward targeted therapies and personalized medicine, chiral compounds like this are becoming increasingly valuable. The fluoro substitution can enhance metabolic stability and membrane permeability, while the nitro group offers opportunities for further chemical modifications. These features make CAS 2227723-37-5 a versatile building block for drug discovery programs.

Market trends indicate growing interest in fluorinated pharmaceutical intermediates, with (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol positioned as a compound of significant potential. The global market for chiral chemicals is projected to expand substantially, driven by demand from the pharmaceutical sector. Companies specializing in custom synthesis and contract research are actively developing improved routes to this and related compounds to meet industry needs.

From a regulatory standpoint, CAS 2227723-37-5 requires careful handling and documentation, though it doesn't fall under restricted categories. Researchers working with this compound must adhere to standard laboratory safety protocols, particularly regarding nitroaromatic compounds. Proper storage conditions and handling procedures are essential to maintain the compound's stability and ensure safe usage in various applications.

The future outlook for (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol appears promising, with potential applications extending beyond pharmaceuticals. Materials science researchers are investigating its use in advanced polymers and functional materials, where its unique combination of substituents could impart desirable properties. As synthetic methodologies continue to advance, we can expect to see broader utilization of this compound across multiple scientific disciplines.

For researchers seeking information about CAS 2227723-37-5, common questions often revolve around its synthetic routes, spectroscopic data, and commercial availability. The compound's chiral purity and methods for its determination are also frequent topics of inquiry. Recent publications have focused on optimizing its preparation and exploring novel derivatives, reflecting the ongoing interest in this structurally intriguing molecule.

In conclusion, (2S)-1-(2-fluoro-3-nitrophenyl)propan-2-ol (CAS No. 2227723-37-5) represents an important compound at the intersection of medicinal chemistry and asymmetric synthesis. Its unique structural features and growing range of applications make it a subject of continued research interest. As the chemical industry evolves toward more sophisticated and targeted molecules, compounds like this will undoubtedly play an increasingly vital role in scientific advancement and technological innovation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)