• 1. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

Chemical Profile of (5-Chloropyrimidin-2-yl)methanol Hydrochloride (CAS No. 2227205-29-8)

(5-Chloropyrimidin-2-yl)methanol hydrochloride, also known by its CAS number 2227205-29-8, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound belongs to the class of pyrimidine derivatives, which have been extensively studied due to their diverse biological activities and potential applications in drug development. The molecule consists of a pyrimidine ring substituted with a chlorine atom at the 5-position and a hydroxymethyl group at the 2-position, which is further protonated to form the hydrochloride salt.

The synthesis of (5-Chloropyrimidin-2-yl)methanol hydrochloride typically involves multi-step organic reactions, often starting from readily available pyrimidine precursors. Recent advancements in synthetic methodologies have enabled the efficient preparation of this compound with high purity, making it more accessible for research purposes. The compound's structure has been confirmed through various spectroscopic techniques, including NMR, IR, and mass spectrometry, ensuring its identity and quality.

In terms of biological activity, (5-Chloropyrimidin-2-yl)methanol hydrochloride has shown promising results in preliminary studies. It exhibits potential as a kinase inhibitor, which is a critical target in the development of anticancer agents. Recent research has highlighted its ability to modulate specific signaling pathways involved in cell proliferation and apoptosis, suggesting its role in antitumor therapies. Additionally, the compound has demonstrated moderate antimicrobial activity against various bacterial strains, indicating its potential use in antibacterial drug design.

The pharmacokinetic properties of (5-Chloropyrimidin-2-yl)methanol hydrochloride have also been investigated, revealing favorable absorption and bioavailability profiles. These findings are crucial for its consideration as a lead compound in preclinical studies. Furthermore, toxicological evaluations have shown that the compound exhibits low toxicity at therapeutic concentrations, which is a positive indicator for its safety profile.

Recent studies have explored the use of (5-Chloropyrimidin-2-yl)methanol hydrochloride as a building block for more complex molecular architectures. By leveraging its structural features, researchers have successfully synthesized novel analogs with enhanced biological activities. For instance, modifications to the substituents on the pyrimidine ring have led to compounds with improved potency against specific targets.

In conclusion, (5-Chloropyrimidin-2-yl)methanol hydrochloride (CAS No. 2227205-29-8) represents a valuable compound with diverse applications in medicinal chemistry. Its unique structure, coupled with promising biological activities, positions it as a compelling candidate for further exploration in drug discovery programs. As research continues to uncover its full potential, this compound is expected to contribute significantly to the development of novel therapeutic agents.

• 63662-58-8
• 54198-89-9(5-chloro-2-methyl-pyrimidine)
• 38275-61-5(5-Chloropyrimidine-2-carboxylic Acid)
• 2168780-37-6(1-(5-chloropyrimidin-2-yl)ethan-1-ol)
• 2247907-41-9(5-chloro-2-(dimethoxymethyl)pyrimidine)
• 944902-98-1((5-Chloropyrimidin-2-yl)methanol)
• 42839-09-8(pyrimidin-2-ylmethanol)
• 2247907-39-5(Pyrimidine, 5-chloro-2-(methoxymethyl)-)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)