Cas no 22236-08-4 (3-(Difluoromethoxy)aniline)

3-(Difluoromethoxy)aniline is a fluorinated aromatic amine with the molecular formula C?H?F?NO. This compound features a difluoromethoxy group (–OCF?H) attached to an aniline moiety, imparting unique electronic and steric properties. Its structural characteristics make it a valuable intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of active ingredients requiring enhanced metabolic stability and lipophilicity. The presence of fluorine atoms contributes to improved bioavailability and resistance to enzymatic degradation. 3-(Difluoromethoxy)aniline is also utilized in material science for designing advanced polymers and specialty chemicals. Its reactivity allows for selective functionalization, enabling precise modifications in target molecules. Proper handling is essential due to its potential toxicity and sensitivity to air and moisture.

3-(Difluoromethoxy)aniline structure

Product Name:3-(Difluoromethoxy)aniline

CAS No:22236-08-4

MF:C₇H₇F₂NO

MW:159.133388757706

MDL:MFCD00236221

CID:52003

PubChem ID:87559163

Update Time:2025-05-21

3-(Difluoromethoxy)aniline Chemical and Physical Properties

Names and Identifiers

- 3-(Difluoromethoxy)aniline
- 3-Difluoromethoxy aniline
- 3-Amino-α,α-difluoroanisole
- 3-difluoromethoxyphenylamine
- m-difluoromethoxyaniline
- α,α-Difluoro-m-anisidine
- m-Anisidine,a,a-difluoro- (8CI)
- 3-(Difluoromethoxy)benzenamine
- 3-[(Difluoromethyl)oxy]aniline
- m-(Difluoromethoxy)aniline
- Benzenamine, 3-(difluoromethoxy)-
- 3-Amino-alpha,alpha-difluoroanisole
- 3-(difluoromethoxy)phenylamine
- PubChem8466
- a,a-Difluoro-m-anisidine
- 3-(difluoromethoxy)-aniline
- Jsp004516
- alpha,alpha-Difluoro-m-anisidine
- MDL： MFCD00236221
- Inchi： 1S/C7H7F2NO/c8-7(9)11-6-3-1-2-5(10)4-6/h1-4,7H,10H2
- InChI Key： RSOFZRXRIPVBBM-UHFFFAOYSA-N
- SMILES： FC(OC1C=CC=C(C=1)N)F

Computed Properties

Exact Mass: 159.05000
Monoisotopic Mass: 159.05
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 11
Rotatable Bond Count: 2
Complexity: 121
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 1.9
Topological Polar Surface Area: 35.2

Experimental Properties

Color/Form: Undetermined 2. density (g/ml, 25/4 ℃)
Density: 1.276?g/mL?at 25?°C(lit.)
Boiling Point: 92°C/2mmHg(lit.)
Flash Point: 225 oF
Refractive Index: n20/D 1.5100(lit.)
PSA: 35.25000
LogP: 2.45140
Sensitiveness: Air Sensitive

3-(Difluoromethoxy)aniline Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H315-H319
Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36/37/38
Safety Instruction： S26-S36
Hazardous Material Identification：
Storage Condition：Keep in dark place,Inert atmosphere,2-8°C
Risk Phrases：R36/37/38
Safety Term：S26;S36

3-(Difluoromethoxy)aniline Customs Data

HS CODE：2922299090
Customs Data：

China Customs Code:
2922299090

Overview:

2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

Declaration elements:

Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

Summary:

2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-(Difluoromethoxy)aniline Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Fluorochem	009628-1g	3-(Difluoromethoxy)aniline	22236-08-4	97%	1g	￡10.00	2022-03-01
Fluorochem	009628-5g	3-(Difluoromethoxy)aniline	22236-08-4	97%	5g	￡20.00	2022-03-01
Fluorochem	009628-10g	3-(Difluoromethoxy)aniline	22236-08-4	97%	10g	￡33.00	2022-03-01
Fluorochem	009628-25g	3-(Difluoromethoxy)aniline	22236-08-4	97%	25g	￡76.00	2022-03-01
Ambeed	A181605-1g	3-(Difluoromethoxy)aniline	22236-08-4	97%	1g	$6.0	2024-07-28
Ambeed	A181605-5g	3-(Difluoromethoxy)aniline	22236-08-4	97%	5g	$24.0	2024-07-28
Ambeed	A181605-10g	3-(Difluoromethoxy)aniline	22236-08-4	97%	10g	$32.0	2024-07-28
Ambeed	A181605-25g	3-(Difluoromethoxy)aniline	22236-08-4	97%	25g	$76.0	2024-07-28
Ambeed	A181605-100g	3-(Difluoromethoxy)aniline	22236-08-4	97%	100g	$275.0	2024-07-28
Alichem	A013000006-250mg	3-(Difluoromethoxy)aniline	22236-08-4	97%	250mg	$504.00	2023-09-02

3-(Difluoromethoxy)aniline Production Method

3-(Difluoromethoxy)aniline Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:22236-08-4)3-(Difluoromethoxy)aniline

Order Number:A816036

Stock Status:in Stock

Quantity:100g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 05:04

Price ($):248.0

Email:[email protected]

Product Official Link

3-(Difluoromethoxy)aniline Related Literature

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2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?

Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
3. Dissociative dynamics of O2 on Ag(110)?

Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies

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5. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?

Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293

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Additional information on 3-(Difluoromethoxy)aniline

Comprehensive Guide to 3-(Difluoromethoxy)aniline (CAS No. 22236-08-4): Properties, Applications, and Industry Trends

3-(Difluoromethoxy)aniline (CAS No. 22236-08-4) is a specialized organic compound widely recognized for its unique chemical structure and versatile applications in pharmaceuticals, agrochemicals, and material science. The compound features a difluoromethoxy group (-OCF₂H) attached to an aniline moiety, which enhances its reactivity and stability under various conditions. This article delves into its molecular characteristics, industrial relevance, and emerging trends, addressing common queries such as "3-(Difluoromethoxy)aniline synthesis" and "CAS 22236-08-4 uses."

The growing demand for fluorinated anilines in drug development has positioned 3-(Difluoromethoxy)aniline as a key intermediate. Researchers frequently search for "fluorinated aromatic amines in medicine" or "bioactive difluoromethoxy compounds," highlighting its role in creating APIs (Active Pharmaceutical Ingredients) with improved metabolic stability. Its electron-withdrawing properties make it valuable for designing kinase inhibitors and antiviral agents, aligning with trends in precision medicine.

In agrochemicals, CAS No. 22236-08-4 is utilized to synthesize herbicides and fungicides with enhanced efficacy. Searches like "difluoromethoxy aniline pesticide applications" reflect industry interest in eco-friendly crop protection solutions. The compound’s ability to modulate lipophilicity contributes to formulations with lower environmental persistence, addressing sustainability concerns.

From a technical perspective, 3-(Difluoromethoxy)aniline exhibits a melting point of 25–28°C and a boiling point of 230–232°C, with solubility in common organic solvents. Analytical techniques such as HPLC and GC-MS are typically employed for purity verification, as queried in "CAS 22236-08-4 analytical methods." Storage recommendations include inert atmospheres to prevent oxidation, a detail often sought under "stability of fluorinated anilines."

Innovations in green chemistry have spurred interest in optimizing the synthesis of 3-(Difluoromethoxy)aniline. Recent patents explore catalytic fluorination methods to reduce byproducts, resonating with searches like "sustainable synthesis of difluoromethoxy derivatives." Additionally, its potential in OLED materials and liquid crystals aligns with the rise of "fluorine-based electronic materials" as a trending topic.

Regulatory compliance for CAS No. 22236-08-4 adheres to global standards like REACH and TSCA. FAQs such as "3-(Difluoromethoxy)aniline safety data" emphasize the need for proper handling protocols, though it is not classified as hazardous under normal use. Suppliers often provide technical dossiers to meet "high-purity fluorinated aniline suppliers" inquiries, ensuring quality for R&D and scale-up processes.

In conclusion, 3-(Difluoromethoxy)aniline (CAS No. 22236-08-4) bridges multiple industries through its functional versatility. Its alignment with cutting-edge research on "fluorine in drug design" and sustainable agriculture underscores its enduring relevance. For detailed specifications or collaboration opportunities, consult certified chemical databases or specialized manufacturers.

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