Cas no 221298-75-5 (8-Bromo-4-chloro-2-methylquinazoline)
8-Bromo-4-chloro-2-methylquinazoline is a halogenated quinazoline derivative with significant utility in pharmaceutical and agrochemical research. Its bromo and chloro substituents enhance reactivity, making it a versatile intermediate for nucleophilic substitution and cross-coupling reactions. The methyl group at the 2-position contributes to steric and electronic modulation, facilitating selective functionalization. This compound is particularly valuable in the synthesis of biologically active molecules, including kinase inhibitors and antimicrobial agents. Its high purity and stability under standard conditions ensure reliable performance in synthetic applications. Researchers favor it for its well-defined reactivity profile and compatibility with diverse reaction conditions, supporting efficient scaffold diversification in drug discovery.
221298-75-5 structure
Product Name:8-Bromo-4-chloro-2-methylquinazoline
CAS No:221298-75-5
MF:C9H6BrClN2
MW:257.514339923859
MDL:MFCD18377827
CID:1091189
PubChem ID:18317810
Update Time:2025-10-14
8-Bromo-4-chloro-2-methylquinazoline Chemical and Physical Properties
Names and Identifiers
-
- 8-Bromo-4-chloro-2-methylquinazoline
- 8-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE
- SCHEMBL6026073
- DTXSID50592748
- 221298-75-5
- HHPRCFVJSYYWEM-UHFFFAOYSA-N
- 2-methyl-4-chloro-8-bromo-quinazoline
-
- MDL： MFCD18377827
- Inchi： 1S/C9H6BrClN2/c1-5-12-8-6(9(11)13-5)3-2-4-7(8)10/h2-4H,1H3
- InChI Key： HHPRCFVJSYYWEM-UHFFFAOYSA-N
- SMILES： BrC1=CC=CC2=C(N=C(C)N=C21)Cl
Computed Properties
- Exact Mass: 255.94029g/mol
- Monoisotopic Mass: 255.94029g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 13
- Rotatable Bond Count: 0
- Complexity: 191
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.6
- Topological Polar Surface Area: 25.8?2
8-Bromo-4-chloro-2-methylquinazoline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | B121195-250mg |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 250mg |
$ 805.00 | 2022-06-07 | ||
| TRC | B121195-500mg |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 500mg |
$ 1340.00 | 2022-06-07 | ||
| Chemenu | CM142134-1g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 1g |
$*** | 2023-03-30 | |
| Chemenu | CM142134-1g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 1g |
$404 | 2021-08-05 | |
| Alichem | A189011126-5g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 5g |
$803.33 | 2023-09-02 | |
| Alichem | A189011126-10g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 10g |
$1137.24 | 2023-09-02 | |
| Alichem | A189011126-25g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 25g |
$2168.15 | 2023-09-02 | |
| eNovation Chemicals LLC | D789136-1g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 1g |
$355 | 2024-06-03 | |
| eNovation Chemicals LLC | D789136-5g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 95% | 5g |
$798 | 2024-06-03 | |
| eNovation Chemicals LLC | D337333-1g |
8-Bromo-4-chloro-2-methylquinazoline |
221298-75-5 | 97% | 1g |
$1000 | 2023-09-03 |
8-Bromo-4-chloro-2-methylquinazoline Related Literature
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Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
-
Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
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Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
-
Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
-
Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
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