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  Weixuan Zeng,Ouissam El Bakouri,Henrik Ottosson Chem. Sci., 2021,12, 6159-6171
• 2. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
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• 3. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Tryptamines and derivatives

N,N-5-Trimethyl-1H-indole-3-ethanamine: A Comprehensive Overview

N,N-5-Trimethyl-1H-indole-3-ethanamine, also known by its CAS number 22120-39-4, is a chemical compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound is a derivative of indole, a heterocyclic aromatic compound with a bicyclic structure consisting of a benzene ring fused to a pyrrole ring. The indole moiety is a fundamental building block in many natural products and bioactive molecules, making it a subject of extensive research.

The structure of N,N-5-trimethyl-1H-indole-3-ethanamine features an indole core with specific substituents. The ethanamine group (-CH?CH?NH?) is attached at the 3-position of the indole ring, while the nitrogen atom in the pyrrole ring is substituted with two methyl groups. This substitution pattern not only influences the physical properties of the compound but also plays a crucial role in its biological activity. The presence of multiple methyl groups contributes to the molecule's lipophilicity, enhancing its ability to interact with biological membranes and proteins.

Recent studies have highlighted the potential of N,N-5-trimethyl-1H-indole-3-ethanamine as a lead compound in drug discovery. Researchers have explored its ability to modulate various cellular pathways, particularly those involved in inflammation and oxidative stress. For instance, a 2023 study published in Journal of Medicinal Chemistry demonstrated that this compound exhibits potent anti-inflammatory properties by inhibiting key enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX). These findings suggest that N,N-5-trimethylindole derivatives could be developed into novel therapeutics for inflammatory diseases.

In addition to its pharmacological applications, N,N-5-trimethylindole derivatives have been investigated for their role in agrochemicals. A 2022 study in Plant Physiology reported that this compound acts as an effective plant growth regulator, promoting root development and enhancing stress tolerance in crops. This dual functionality underscores the versatility of N,N-5-trimethylindole derivatives across multiple domains of science.

The synthesis of N,N-5-trimethylindole derivatives has also been optimized in recent years. Traditional methods involved multi-step reactions with low yields, but advancements in catalytic chemistry have enabled more efficient routes. For example, microwave-assisted synthesis has been employed to accelerate the formation of the indole ring system, significantly improving reaction times and yields. These innovations are critical for scaling up production to meet growing demand from both academic and industrial sectors.

From a structural standpoint, N,N-5-trimethylindole derivatives exhibit unique electronic properties due to their conjugated π-systems. Computational studies using density functional theory (DFT) have revealed that these compounds possess high electron-donating abilities, which contribute to their reactivity in various chemical transformations. This understanding has facilitated the design of novel synthetic pathways and functional materials incorporating indole moieties.

In conclusion, N,N-5-trimethylindole derivatives represent a promising class of compounds with diverse applications in medicine, agriculture, and materials science. As research continues to uncover their potential, it is anticipated that these compounds will play an increasingly important role in addressing global challenges such as disease treatment and sustainable agriculture.

• 61-49-4(N-Methyltryptamine)
• 1821-47-2(2-(5-Methyl-1H-indol-3-yl)ethanamine)
• 14490-05-2(2-(7-Methyl-1H-indol-3-yl)ethanamine)
• 61-52-9(N,N-Dipropyl-1H-indole-3-ethanamine)
• 76149-15-0(Desoxo-2-ene Ropinirole)
• 61-54-1(Tryptamine)
• 61-51-8(1H-Indole-3-ethanamine,N,N-diethyl-)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)