• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 3. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

3-t-Butoxycarbonylphenylboronic Acid (CAS 220210-56-0): A Versatile Boronic Acid Derivative for Organic Synthesis

3-t-Butoxycarbonylphenylboronic acid (CAS 220210-56-0) is an important boronic acid derivative widely used in organic synthesis, pharmaceutical research, and material science. This compound belongs to the class of arylboronic acids, which have gained significant attention due to their unique reactivity in Suzuki-Miyaura cross-coupling reactions – one of the most powerful tools for carbon-carbon bond formation in modern chemistry.

The molecular structure of 3-t-butoxycarbonylphenylboronic acid features both a boronic acid functional group (-B(OH)₂) and a t-butoxycarbonyl (Boc) protecting group. This combination makes it particularly valuable for peptide synthesis and the preparation of complex organic molecules, addressing current research trends in drug discovery and bioconjugation chemistry.

In pharmaceutical applications, 3-t-butoxycarbonylphenylboronic acid CAS 220210-56-0 serves as a key intermediate for the synthesis of various biologically active compounds. Researchers frequently search for "boronic acid drug candidates" as these molecules show promise in developing enzyme inhibitors and proteasome inhibitors, particularly in cancer research. The Boc-protected variant offers advantages in controlled release and targeted drug delivery systems.

The compound's stability and reactivity profile make it ideal for polymer chemistry applications. Materials scientists are exploring its use in creating self-healing materials and smart polymers, responding to growing interest in sustainable material development. The boronic acid moiety enables dynamic covalent bonding, a hot topic in "adaptive materials chemistry" research.

From a synthetic chemistry perspective, 3-t-Boc-phenylboronic acid demonstrates excellent compatibility with various reaction conditions. Its orthogonal protecting group strategy allows sequential functionalization – a technique highly valued in multistep synthesis workflows. This addresses common search queries about "protecting group strategies in organic synthesis" and "compatible functional groups for Suzuki coupling".

Quality control of 3-t-butoxycarbonylphenylboronic acid 220210-56-0 typically involves analytical techniques like HPLC, NMR spectroscopy, and mass spectrometry. Purity specifications often exceed 97%, meeting the stringent requirements of pharmaceutical-grade intermediates. These analytical aspects respond to frequent searches about "characterization of boronic acid derivatives" and "quality control in fine chemicals".

The compound's storage and handling require attention to moisture sensitivity, a common characteristic of boronic acid compounds. Proper storage under inert atmosphere and low temperature ensures maximum stability, addressing practical concerns frequently searched by laboratory technicians and researchers working with air-sensitive reagents.

Market trends show increasing demand for 3-t-butoxycarbonylphenylboronic acid CAS 220210-56-0, particularly from contract research organizations and academic institutions engaged in medicinal chemistry projects. The growing interest in boron-containing drugs and bioconjugates has further driven its adoption in drug discovery pipelines worldwide.

Environmental considerations for 3-t-Boc-phenylboronic acid synthesis and disposal align with current "green chemistry" initiatives. Researchers are investigating more sustainable routes for producing such organoboron compounds, responding to industry-wide efforts to reduce the environmental impact of chemical synthesis.

In conclusion, 3-t-butoxycarbonylphenylboronic acid (220210-56-0) represents a valuable building block in modern synthetic chemistry. Its unique combination of boronic acid functionality and Boc protection addresses multiple current research needs, from drug development to advanced materials creation. As the scientific community continues to explore the potential of boron chemistry, this compound is likely to maintain its importance in various chemical disciplines.

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