• 1. Synthesis of fluorescent 2,3,5,6-tetraalkynylpyridines by site-selective Sonogashira-reactions of 2,3,5,6-tetrachloropyridines
  Peter Ehlers,Andranik Petrosyan,Antje Neubauer,Timo Br?se,Stefan Lochbrunner,Tariel V. Ghochikyan,Ashot S. Saghyan,Peter Langer Org. Biomol. Chem. 2014 12 8627
• 2. Palladium dichloride adduct of N,N-bis-(diphenylphosphanylmethyl)-2-aminopyridine: synthesis, structure and catalytic performance in the decarboxylative cross-coupling of 4-picolinic acid with aryl bromide
  Run-Tian He,Jian-Feng Wang,Hui-Fang Wang,Zhi-Gang Ren,Jian-Ping Lang Dalton Trans. 2014 43 9786

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

Comprehensive Overview of 4-(4-(Trifluoromethyl)phenyl)pyridine (CAS No. 220000-88-4)

4-(4-(Trifluoromethyl)phenyl)pyridine, with the CAS number 220000-88-4, is a specialized organic compound that has garnered significant attention in pharmaceutical and materials science research. This compound features a pyridine ring linked to a phenyl group substituted with a trifluoromethyl moiety, a structural motif known for enhancing metabolic stability and lipophilicity in drug design. Its unique properties make it a valuable intermediate in the synthesis of bioactive molecules and advanced materials.

The growing interest in 4-(4-(Trifluoromethyl)phenyl)pyridine is driven by its potential applications in medicinal chemistry, particularly in the development of kinase inhibitors and central nervous system (CNS) therapeutics. Researchers are exploring its role in modulating protein-protein interactions, a hot topic in drug discovery. Additionally, its trifluoromethyl group contributes to improved bioavailability, a key consideration in modern pharmaceutical formulations.

In the field of material science, CAS 220000-88-4 is investigated for its utility in organic electronics, such as OLEDs (Organic Light-Emitting Diodes) and photovoltaic cells. The compound's electron-withdrawing trifluoromethyl group enhances charge transport properties, aligning with the global push for sustainable energy solutions. This dual applicability in life sciences and green technology positions it as a compound of high interdisciplinary relevance.

From a synthetic perspective, 4-(4-(Trifluoromethyl)phenyl)pyridine is often prepared via Suzuki-Miyaura cross-coupling, a widely used palladium-catalyzed reaction. This method highlights the compound's compatibility with modern synthetic methodologies, a frequent search topic among organic chemists. Its stability under various conditions also makes it suitable for high-throughput screening in drug development pipelines.

Environmental and regulatory considerations surrounding fluorinated compounds have sparked discussions about the green chemistry aspects of 220000-88-4. While not classified as hazardous, researchers are investigating biodegradation pathways and eco-friendly synthesis routes to align with EPA guidelines and REACH compliance – trending topics in chemical sustainability forums.

Analytical characterization of 4-(4-(Trifluoromethyl)phenyl)pyridine typically involves NMR spectroscopy (particularly 19F-NMR for the trifluoromethyl group), mass spectrometry, and HPLC purity analysis. These techniques address common queries about compound verification in peer-reviewed research. The compound's crystallographic data has also been studied to understand its molecular packing behavior, relevant for crystal engineering applications.

The commercial availability of CAS 220000-88-4 through specialty chemical suppliers has facilitated its adoption in both academic and industrial settings. Current market trends show increased demand for such fluorinated building blocks, driven by the pharmaceutical industry's focus on targeted therapies and personalized medicine approaches. This aligns with frequent searches about scalable synthesis and GMP-grade intermediates.

Future research directions for 4-(4-(Trifluoromethyl)phenyl)pyridine may explore its potential in proteolysis targeting chimeras (PROTACs) and covalent inhibitors, two rapidly evolving areas in drug development. Its structural features could also be valuable in designing metal-organic frameworks (MOFs) for gas storage applications. These applications respond to growing interest in multifunctional materials and next-generation therapeutics across scientific communities.

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