• 1. Decoding lignin valorization pathways in the extremophilic Bacillus ligniniphilus L1 for vanillin biosynthesis
  Daochen Zhu,Lingxia Xu,Sivasamy Sethupathy,Haibing Si,Fiaz Ahmad,Rongxian Zhang,Weimin Zhang,Bin Yang,Jianzhong Sun Green Chem. 2021 23 9554
• 2. Dihydrochalcone-derived polyphenols from tea crab apple (Malus hupehensis) and their inhibitory effects on α-glucosidase in vitro
  Qiuyue Lv,Yushan Lin,Zhexu Tan,Baoping Jiang,Lijia Xu,Haiqin Ren,William Chi-shing Tai,Chi-on Chan,Chi-sing Lee,Zhengbing Gu,Daniel K. W. Mok,Sibao Chen Food Funct. 2019 10 2881
• 3. Phenolic cross-links: building and de-constructing the plant cell wall
  Ewelina Mnich,Nanna Bjarnholt,Aymerick Eudes,Jesper Harholt,Claire Holland,Bodil J?rgensen,Flemming Hofmann Larsen,Ming Liu,Renil Manat,Anne S. Meyer,J?rn Dalgaard Mikkelsen,Mohammed Saddik Motawia,Jan Muschiol,Birger Lindberg M?ller,Svenning Rune M?ller,Alixander Perzon,Bent Larsen Petersen,Jonas Laukkonen Ravn,Peter Ulvskov Nat. Prod. Rep. 2020 37 919

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl-phenylketones

3-Hydroxy-1-(4-Hydroxy-3-Methoxy-Phenyl)Propan-1-One: A Comprehensive Overview

3-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one, also known by its CAS number 2196-18-1, is a versatile organic compound with significant applications in the fields of medicinal chemistry and pharmaceutical research. This compound, often referred to as homovanillyl alcohol, is a derivative of vanillin and has garnered attention for its potential therapeutic properties and biological activities.

The molecular structure of 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one consists of a phenyl ring substituted with hydroxyl and methoxy groups, along with a hydroxylated propanone side chain. This unique configuration imparts the compound with a range of chemical and biological properties that make it an interesting subject for scientific investigation.

Recent studies have highlighted the potential of 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one in various therapeutic areas. One notable application is its use as an antioxidant. Research published in the Journal of Medicinal Chemistry has demonstrated that this compound exhibits potent antioxidant activity, which can help protect cells from oxidative stress and damage. This property makes it a promising candidate for the development of drugs targeting oxidative stress-related diseases such as neurodegenerative disorders and cardiovascular diseases.

In addition to its antioxidant properties, 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one has shown potential in anti-inflammatory and anti-cancer research. Studies have indicated that this compound can inhibit the production of pro-inflammatory cytokines and reduce inflammation in vitro. Furthermore, preliminary investigations have suggested that it may possess anti-proliferative effects on certain cancer cell lines, making it a potential lead compound for the development of novel anti-cancer therapies.

The pharmacokinetic properties of 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one have also been studied to assess its suitability as a drug candidate. Research has shown that it has favorable absorption, distribution, metabolism, and excretion (ADME) profiles, which are crucial for ensuring effective drug delivery and minimizing side effects. These findings suggest that further optimization and clinical testing could lead to the development of new therapeutic agents based on this compound.

In the context of drug discovery, 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one serves as a valuable starting point for structure-based drug design. Its molecular scaffold can be modified to enhance specific biological activities or improve pharmacological properties. For instance, researchers have explored the synthesis of derivatives with enhanced antioxidant or anti-inflammatory activities by introducing various functional groups or altering the existing substituents.

The safety profile of 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one is another important aspect that has been investigated. Preclinical studies have generally shown that this compound is well-tolerated at therapeutic doses, with minimal toxicity observed in animal models. However, further safety assessments are necessary to ensure its suitability for human use.

In conclusion, 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one, identified by its CAS number 2196-18-1, is a multifaceted compound with promising therapeutic potential. Its antioxidant, anti-inflammatory, and anti-cancer properties make it an attractive target for further research and development in the pharmaceutical industry. As ongoing studies continue to uncover new insights into its mechanisms of action and biological effects, this compound is poised to play a significant role in advancing medical treatments for various diseases.

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