• 1. Electron transfer in complexes of BII cations with organic π-acceptors: a combined experimental and quantum-chemical study
  Daniel Vogler,Nina Wolf,Elisabeth Kaifer,Hans-J?rg Himmel Dalton Trans. 2019 48 14354
• 2. Synthesis of functionalised BTPhen derivatives – effects on solubility and americium extraction
  Matthew A. Higginson,Nichola D. Kyle,Olivia J. Marsden,Paul Thompson,Francis R. Livens,Sarah L. Heath Dalton Trans. 2015 44 16547
• 3. 188. Synthetical experiments in the o-terphenyl series. Part II
  R. L. Huang,Kheng-Hoon Lee J. Chem. Soc. 1959 923
• 4. Electric dipole moments and molecular conformations of benzophenones, benzils, benzhydrols, and benzoins
  C. W. N. Cumper,A. P. Thurston J. Chem. Soc. Perkin Trans. 2 1972 106
• 5. IV.—The influence of substituents on the benzoin reaction
  Herbert Henry Hodgson,Wolf Rosenberg J. Chem. Soc. 1930 14

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes Stilbenes
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes

1,2-Bis(2-chlorophenyl)-1,2-ethanedione: A Comprehensive Overview

1,2-Bis(2-chlorophenyl)-1,2-ethanedione (CAS No. 21854-95-5) is a versatile organic compound with significant applications in various fields of chemistry and materials science. This compound, often referred to as DDQ analog, has garnered attention due to its unique structural properties and potential uses in drug design, material synthesis, and environmental chemistry. The molecule consists of two chlorophenyl groups attached to a central ethanedione core, which imparts it with distinctive electronic and steric characteristics.

Recent advancements in computational chemistry have enabled researchers to delve deeper into the electronic structure of 1,2-Bis(2-chlorophenyl)-1,2-ethanedione. Studies utilizing density functional theory (DFT) have revealed that the compound exhibits a high degree of conjugation across its aromatic rings and the diketone moiety. This conjugation not only enhances its stability but also contributes to its ability to act as a redox-active species in various chemical reactions. The presence of electron-withdrawing chlorine atoms further modulates the electronic properties of the molecule, making it an attractive candidate for applications in organic electronics.

The synthesis of 1,2-Bis(2-chlorophenyl)-1,2-ethanedione typically involves multi-step organic reactions. One common approach involves the Friedel-Crafts acylation of chlorobenzene derivatives followed by oxidation to form the diketone structure. Recent optimizations in this synthesis pathway have focused on improving yield and reducing reaction times by employing catalytic systems such as transition metal catalysts or enzymatic methods. These advancements have made the compound more accessible for large-scale production and research purposes.

In terms of applications, 1,2-Bis(2-chlorophenyl)-1,2-ethanedione has found utility in the field of drug discovery. Its ability to act as a chelating agent has been leveraged in designing metalloenzyme inhibitors and anti-inflammatory agents. Additionally, the compound has been explored as a building block for constructing bioactive molecules with potential anticancer properties. Recent studies have demonstrated that derivatives of this compound can induce apoptosis in cancer cells by targeting specific signaling pathways.

The environmental impact of 1,2-Bis(2-chlorophenyl)-1,2-ethanedione has also been a topic of interest. Research into its biodegradation pathways has revealed that under aerobic conditions, the compound undergoes microbial transformation through hydroxylation and ring-opening mechanisms. These findings are crucial for assessing its ecological safety and guiding its responsible use in industrial settings.

From a materials science perspective, 1,2-Bis(2-chlorophenyl)-1,2-ethanedione has been investigated as a precursor for synthesizing advanced materials such as conductive polymers and coordination polymers. Its ability to coordinate with metal ions makes it a valuable component in designing functional materials for energy storage devices and sensors.

In conclusion, 1,2-Bis(2-chlorophenyl)-1,2-ethanedione (CAS No. 21854-95-5) is a multifaceted compound with diverse applications across various scientific domains. Ongoing research continues to uncover new insights into its properties and potential uses, solidifying its position as an important molecule in modern chemistry.

• 72867-72-2(2'-2'-Chloro-2-phenylacetophenone)
• 64497-33-2(1-(2-Chlorophenyl)propane-1,2-dione)
• 7504-29-2( )
• 99846-93-2(1-(2,5-dichlorophenyl)propan-1-one)
• 84126-33-0(Ethanone, 2-(2,6-dichlorophenyl)-1-phenyl-)
• 6323-18-8(1-(2-Chlorophenyl)propan-1-one)
• 94171-11-6(2-(4-Chlorophenyl)-1-(2,4-Dichlorophenyl)Ethanone)
• 57479-60-4(2-(2-Chlorophenyl)-1-phenylethan-1-one)
• 654682-18-5(1-(4-Chlorophenyl)-2-(2,4-Dichlorophenyl)Ethanone)
• 77778-75-7(Ethanone, 1,2-bis(2-chlorophenyl)-)