• 1. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine: A Comprehensive Overview

6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine (CAS No. 2172496-15-8) is a structurally unique compound belonging to the imidazo[1,2-a]pyridine family. This compound has garnered significant attention in recent years due to its potential applications in various fields, including pharmacology and materials science. The imidazo[1,2-a]pyridine core is a bicyclic structure that combines the properties of both imidazole and pyridine rings, making it a versatile scaffold for chemical modifications. The presence of an iodo group at the 6-position and two methyl groups at the 3 and 5 positions further enhances its chemical reactivity and biological activity.

Recent studies have highlighted the importance of 6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine in drug discovery. Its ability to act as a precursor for more complex molecules has been exploited in the synthesis of novel pharmaceutical agents. For instance, researchers have demonstrated that this compound can undergo various substitution reactions to yield derivatives with enhanced bioavailability and selectivity. The iodo group serves as an excellent leaving group, enabling the formation of diverse functionalized products that can target specific biological pathways.

The synthesis of 6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine involves a multi-step process that typically begins with the preparation of the imidazo[1,2-a]pyridine core. This is followed by iodination at the 6-position and methylation at the 3 and 5 positions. The reaction conditions are carefully optimized to ensure high yields and purity. Recent advancements in catalytic methods have further streamlined this process, making it more efficient and scalable for industrial applications.

In terms of pharmacological activity, 6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine has shown promise as a lead compound for anti-inflammatory and anti-cancer therapies. Its ability to modulate key enzymes involved in inflammatory responses has been extensively studied. Additionally, its role as a potential anticancer agent has been explored through in vitro assays that demonstrate its ability to inhibit tumor cell proliferation while sparing normal cells.

The structural versatility of 6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine also makes it a valuable component in materials science. Its application as a building block for advanced materials such as conductive polymers and metal-organic frameworks (MOFs) has been reported in recent literature. The methyl groups provide steric hindrance that can influence the electronic properties of these materials, making them suitable for energy storage applications.

Furthermore, the use of 6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine in analytical chemistry has been documented. Its ability to act as a chelating agent for metal ions has been leveraged in the development of sensors for heavy metal detection. This application underscores its potential in environmental monitoring and quality control processes.

In conclusion, 6-Iodo-3,5-Dimethylimidazo[1,2-a]pyridine (CAS No. 2172496-15-8) is a multifaceted compound with a wide range of applications across different scientific disciplines. Its unique structure and reactivity make it an invaluable tool in drug discovery, materials science, and analytical chemistry. As research continues to uncover new avenues for its utilization, this compound is poised to play an increasingly important role in advancing scientific innovation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)