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Comprehensive Guide to 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid (CAS No. 2172153-03-4)

4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid (CAS No. 2172153-03-4) is a specialized organic compound widely utilized in peptide synthesis and pharmaceutical research. This compound belongs to the class of Fmoc-protected amino acid derivatives, which are critical in solid-phase peptide synthesis (SPPS). The Fmoc group serves as a protective moiety for amines, ensuring selective reactions during peptide chain elongation. Researchers and pharmaceutical companies frequently seek this compound for its high purity and compatibility with automated peptide synthesizers.

The molecular structure of 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid features a but-2-ynamido linker, which enhances its reactivity in coupling reactions. This property makes it particularly valuable in the synthesis of complex peptides and peptidomimetics. Given the growing demand for peptide-based therapeutics, this compound has garnered significant attention in drug discovery and biotechnology. Its CAS number, 2172153-03-4, is often searched in scientific databases for procurement and research purposes.

One of the key advantages of 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid is its stability under standard laboratory conditions. The Fmoc-protected amine ensures that the compound remains inert to unwanted side reactions, making it ideal for multi-step synthetic procedures. Additionally, its solubility in common organic solvents like DMF and DMSO facilitates its use in high-throughput screening and combinatorial chemistry. These attributes align with current trends in precision medicine and targeted drug delivery, where peptide-based molecules play a pivotal role.

In recent years, the pharmaceutical industry has witnessed a surge in the development of peptide drugs due to their high specificity and low toxicity. 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid is frequently employed in the synthesis of GPCR-targeting peptides and enzyme inhibitors. These applications are particularly relevant in the context of cancer research and neurodegenerative diseases, where peptide therapeutics offer promising avenues for treatment. Researchers often inquire about the synthetic protocols and handling precautions for this compound, underscoring its importance in modern drug development.

The versatility of 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid extends to its use in bioconjugation and proteomics. Its alkyne functional group enables click chemistry reactions, which are instrumental in labeling biomolecules for imaging and diagnostic applications. This feature is especially valuable in the era of theranostics, where diagnostic and therapeutic functions are integrated into a single agent. As such, the compound is a staple in laboratories focused on molecular imaging and drug-target interaction studies.

From a commercial perspective, 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid is available in various grades, including research-grade and GMP-grade, catering to diverse industrial needs. Suppliers often highlight its high batch-to-batch consistency and low impurity profiles, which are critical for regulatory compliance in pharmaceutical manufacturing. The compound’s CAS number, 2172153-03-4, is a key identifier in procurement databases, ensuring accurate sourcing for global research institutions.

In conclusion, 4-4-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-N-(propan-2-yl)but-2-ynamidobutanoic acid (CAS No. 2172153-03-4) is a cornerstone in peptide chemistry and pharmaceutical research. Its unique structural features and broad applicability make it indispensable for scientists working on next-generation therapeutics and biomolecular engineering. As the demand for peptide-based drugs continues to rise, this compound will remain at the forefront of innovative medical solutions.

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