Cas no 216672-17-2 (3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt)

3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt is a fluorogenic substrate widely used in enzymatic assays, particularly for detecting β-glucuronidase activity. Its key advantages include high sensitivity and specificity, enabling precise quantification of enzyme activity in biological samples. Upon cleavage by β-glucuronidase, the compound releases the fluorescent 3-carboxyumbelliferone, facilitating real-time monitoring with minimal background interference. The dipotassium salt form enhances solubility in aqueous buffers, ensuring consistent performance in biochemical and diagnostic applications. This substrate is ideal for research involving microbial detection, cell viability assays, and high-throughput screening, offering reliable and reproducible results. Its stability and low autofluorescence further contribute to its utility in sensitive analytical workflows.
3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt structure
216672-17-2 structure
Product Name:3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt
CAS No:216672-17-2
MF:C16H14O11
MW:382.275765895844
CID:243328
PubChem ID:22860349
Update Time:2025-10-24

3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt Chemical and Physical Properties

Names and Identifiers

    • b-D-Glucopyranosiduronic acid,3-carboxy-2-oxo-2H-1-benzopyran-7-yl, dipotassium salt (9CI)
    • 7-[(2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-2-oxochromene-3-carboxylic acid
    • CARBOXYUMBELLIFERYL-?D-GLUCURONIDE (CUGICU)
    • 3-Carboxyumbelliferyl-b-D-glucuronide
    • Carboxyumbelliferyl-?-D-Glucuronide (CUGIcU)
    • W0182
    • carboxyumbelliferyl beta-d-glucuronide
    • 651740-66-8
    • CUGlcU
    • 3-carboxyumbelliferyl beta-d-glucuronide
    • 3-Carboxy-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid
    • 7-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yloxy)-2-oxo-2H-chromene-3-carboxylic acid
    • 7-[(2S, 3R, 4S, 5S, 6S)-6-carboxy-3, 4, 5-trihydroxyoxan-2-yl]oxy-2-oxochromene-3-carboxylic acid
    • 7-{[(2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy}-2-oxo-2H-chromene-3-carboxylic acid
    • SCHEMBL5262002
    • 7-(((2S,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2-oxo-2H-chromene-3-carboxylic acid
    • W-201892
    • 216672-17-2
    • DTXSID00628682
    • 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt
    • Inchi: 1S/C16H14O11/c17-9-10(18)12(14(22)23)27-16(11(9)19)25-6-2-1-5-3-7(13(20)21)15(24)26-8(5)4-6/h1-4,9-12,16-19H,(H,20,21)(H,22,23)/t9-,10-,11+,12-,16+/m0/s1
    • InChI Key: FYKJWPNWCJGLBP-DKQGBHPVSA-N
    • SMILES: O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1C(=O)O)O)O)O)OC1=CC=C2C=C(C(=O)O)C(=O)OC2=C1

Computed Properties

  • Exact Mass: 382.05400
  • Monoisotopic Mass: 382.05361126g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 5
  • Hydrogen Bond Acceptor Count: 11
  • Heavy Atom Count: 27
  • Rotatable Bond Count: 4
  • Complexity: 659
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 5
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.3
  • Topological Polar Surface Area: 180?2

Experimental Properties

  • Density: 1.837
  • Boiling Point: 758.7°C at 760 mmHg
  • Flash Point: 281°C
  • Refractive Index: 1.711
  • PSA: 183.96000
  • LogP: -1.23780

3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt Security Information

3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt Pricemore >>

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Additional information on 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt

Introduction to 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt (CAS No. 216672-17-2) in Modern Chemical and Biomedical Research

The compound 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt, identified by the chemical abstracts service number 216672-17-2, represents a significant advancement in the field of chemobiology and pharmaceutical innovation. This specialized derivative of umbelliferyl, a naturally occurring coumarin derivative, has garnered considerable attention due to its unique structural and functional properties. The β-D-glucuronide moiety appended to the umbelliferyl core enhances solubility and bioavailability, making it an attractive candidate for a variety of biomedical applications.

Recent research has highlighted the potential of 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt as a versatile tool in diagnostic imaging and drug delivery systems. Its fluorescence properties, derived from the umbelliferyl chromophore, make it an excellent probe for cellular studies. Moreover, the dipotassium salt form improves water solubility, facilitating its use in aqueous-based formulations and enhancing its compatibility with biological systems.

In the realm of drug development, this compound has been explored for its potential as a prodrug or a carrier molecule. The glucuronide group is known to enhance metabolic stability and prolong circulation time in biological systems, which is particularly valuable for targeted drug delivery. Studies have demonstrated its efficacy in encapsulating hydrophobic drugs, thereby improving their bioavailability and therapeutic efficacy.

One of the most compelling aspects of 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt is its application in bioimaging techniques. The compound’s ability to emit fluorescence upon excitation with UV light allows researchers to visualize biological processes in real-time with high resolution. This has opened new avenues in cellular and molecular biology, enabling more precise tracking of biological pathways and interactions.

The structural integrity of this compound also lends itself to modifications that can fine-tune its pharmacokinetic properties. Researchers have experimented with various derivatives to optimize its binding affinity, stability, and biodistribution. These modifications have shown promise in enhancing the compound’s utility as an imaging agent and as a component in drug delivery systems.

Advances in synthetic chemistry have made large-scale production of 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt more feasible than ever before. Modern synthetic routes have improved yield and purity, reducing costs and making the compound more accessible for research purposes. This accessibility has spurred further innovation, with researchers exploring new applications across multiple disciplines.

The compound’s role in environmental science is also emerging as a critical area of study. Its fluorescence properties make it an excellent indicator for environmental monitoring applications, such as detecting pollutants or monitoring microbial activity in aquatic ecosystems. The stability and specificity of 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt make it particularly useful for these applications.

Future directions for research on 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt include exploring its potential as an anti-inflammatory agent or as a component in gene therapy vectors. Its ability to cross cell membranes efficiently suggests that it could be used to deliver therapeutic agents directly to target cells, improving treatment outcomes.

The development of novel derivatives continues to be a major focus area. By modifying the chemical structure of this compound, researchers aim to enhance its therapeutic potential while minimizing side effects. These efforts are part of a broader trend toward personalized medicine, where compounds are tailored to individual patient needs based on their unique biological profiles.

The impact of 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt extends beyond academic research into practical applications that benefit society. Its use in diagnostic tools has improved early detection of diseases, leading to better patient outcomes. Similarly, its role in drug delivery systems has revolutionized how medications are administered, improving treatment efficacy and reducing adverse effects.

In conclusion, 3-Carboxyumbelliferyl-β-D-glucuronide Dipotassium Salt (CAS No. 216672-17-2) stands as a testament to the power of interdisciplinary research in advancing biomedical science. Its unique properties make it a valuable tool across multiple fields, from diagnostics to drug development. As research continues to uncover new applications for this compound, its significance is poised to grow even further.

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