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Comprehensive Guide to N-Hexane-d14 (CAS No. 21666-38-6): Properties, Applications, and Industry Insights

N-Hexane-d14, identified by its CAS number 21666-38-6, is a deuterated form of n-hexane, a widely used solvent in analytical chemistry and research. This isotopically labeled compound has gained significant attention due to its unique properties, making it indispensable in NMR spectroscopy, mass spectrometry, and deuterium labeling studies. As laboratories increasingly adopt advanced techniques, the demand for high-purity deuterated solvents like N-Hexane-d14 continues to rise.

The molecular structure of N-Hexane-d14 features 14 deuterium atoms replacing all hydrogen atoms in the hexane chain, resulting in enhanced stability and minimal interference in sensitive experiments. Researchers frequently search for "N-Hexane-d14 uses" or "CAS 21666-38-6 specifications" to understand its role in quantitative analysis and isotope dilution methods. Its low proton background makes it ideal for deuterium NMR applications, where signal clarity is critical.

Recent trends show growing interest in sustainable laboratory practices, prompting questions like "Is N-Hexane-d14 recyclable?" While deuterated compounds require specialized handling, their reusability in certain processes aligns with green chemistry initiatives. The compound’s compatibility with GC-MS systems and HPLC methodologies also positions it as a versatile tool for pharmaceutical impurity profiling and environmental analysis.

Analytical laboratories often inquire about "N-Hexane-d14 vs. protonated hexane" when designing experiments. The key advantage lies in its ability to eliminate solvent peak overlap in spectra, a common challenge in structural elucidation. Manufacturers emphasize ≥99.5% isotopic purity (a frequent search term) to ensure reproducibility in kinetic studies and metabolic research.

Emerging applications in battery electrolyte research and deuterium oxide tracing have further expanded the relevance of CAS 21666-38-6. With the rise of AI-assisted molecular modeling, accurate experimental data using deuterated standards becomes paramount—explaining why queries like "N-Hexane-d14 computational chemistry" are increasing. Proper storage conditions (argon atmosphere, light-sensitive packaging) remain critical discussion points among purchasers.

As regulatory standards evolve, documentation for deuterated chemical compliance (e.g., REACH certification for 21666-38-6) has become a priority for suppliers. The compound’s role in COVID-19 drug development (as a tracer solvent) and biomarker discovery underscores its cross-disciplinary value. For researchers comparing "N-Hexane-d14 price per gram," factors like batch-to-batch consistency and supplier reliability often outweigh cost considerations.

Future directions may see N-Hexane-d14 integrated into quantum sensing technologies and neutron scattering experiments, given deuterium’s unique nuclear properties. Current best practices recommend verifying residual proton content via FTIR validation—a technical detail increasingly searched alongside the CAS number. This reflects the compound’s niche yet expanding role in precision science.

• 113122-31-9(Dodecane-1-d (9CI))
• 297-15-4(Cyclopentacosane)
• 297-47-2(Cyclotetratriacontane)
• 68109-06-8(CYCLOTETRATETRACONTAHECTANE)
• 64837-00-9(CYCLOHENTRIACONTANE)
• 68718-69-4(CYCLODECYLIUM)
• 25453-92-3
• 79096-99-4(BUTYLIUM, 1-ETHYL-)
• 63217-82-3(CYCLOEICOSAHECTANE)
• 19414-29-0