• 1. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines

Comprehensive Guide to 4-Chloro-2-fluoro-6-iodoaniline (CAS No. 216393-67-8): Properties, Applications, and Industry Insights

4-Chloro-2-fluoro-6-iodoaniline (CAS 216393-67-8) is a halogen-substituted aniline derivative with significant relevance in pharmaceutical and agrochemical research. This compound, characterized by its multi-halogenated aromatic structure, serves as a versatile intermediate in organic synthesis. Its unique chloro-fluoro-iodo substitution pattern enables selective reactivity, making it valuable for constructing complex molecules in drug discovery and material science.

In recent years, the demand for halogenated anilines like 4-Chloro-2-fluoro-6-iodoaniline has surged due to their role in developing targeted therapeutics and crop protection agents. Researchers frequently search for "iodoaniline derivatives in medicinal chemistry" or "fluoro-chloro aniline applications," reflecting growing interest in its synthetic utility. The compound's CAS 216393-67-8 is often queried alongside "cross-coupling reactions" and "heterocyclic synthesis," highlighting its importance in modern catalytic transformations.

The molecular structure of 4-Chloro-2-fluoro-6-iodoaniline features three distinct halogens – chlorine, fluorine, and iodine – each contributing specific electronic effects. The ortho-fluoro substituent enhances metabolic stability in drug candidates, while the para-iodo group facilitates palladium-catalyzed couplings, a technique dominating pharmaceutical patent literature. These attributes explain why searches for "halogen effects in drug design" frequently reference this compound class.

From an industrial perspective, 216393-67-8 aligns with sustainability trends through its potential in late-stage functionalization strategies. Manufacturers increasingly optimize routes to minimize waste, responding to queries like "green synthesis of halogenated aromatics." The compound's melting point (typically 98-102°C) and solubility profile make it suitable for high-throughput screening applications, another trending search topic in combinatorial chemistry circles.

Analytical characterization of 4-Chloro-2-fluoro-6-iodoaniline typically involves HPLC purity analysis (≥97%) and mass spectrometry confirmation. These quality control aspects address common purchaser concerns about "halogenated compound stability" and "aniline derivative storage." The compound's stability under inert atmosphere meets stringent requirements for electronic materials precursors, connecting to OLED and semiconductor industry needs.

Emerging applications in PET radiopharmaceuticals have brought new attention to iodoanilines like CAS 216393-67-8, with researchers investigating "radioiodination precursors" for diagnostic imaging. This aligns with healthcare's precision medicine movement, where searches for "fluorine-iodine synergism" in bioactive molecules have increased 300% since 2020 according to chemical literature databases.

Regulatory compliance for 4-Chloro-2-fluoro-6-iodoaniline focuses on standard laboratory safety protocols rather than restrictive classifications. This distinguishes it from heavily regulated compounds, making it accessible for academic and industrial research teams investigating "benign halogenation methods" or "scalable aromatic amination" – both trending topics in process chemistry forums.

The synthesis of 216393-67-8 typically proceeds through sequential halogenation reactions, with recent methodological improvements reducing heavy metal residues. These advances respond to frequent queries about "transition-metal-free halogenation" techniques. Patent analysis reveals growing IP activity around derivatives of this compound, particularly in kinase inhibitor development.

In material science, the iodo-aniline moiety enables precise molecular engineering of conjugated polymers. This explains rising search volumes for "halogenated monomers for organic electronics." The compound's crystalline nature also makes it valuable for co-crystal screening – a hot topic in pharmaceutical formulation circles.

For purchasers, technical specifications of 4-Chloro-2-fluoro-6-iodoaniline typically emphasize low heavy metal content (<10 ppm) and consistent halogen stoichiometry. These parameters address quality concerns reflected in search terms like "high-purity iodoaromatics" and "halogenated building block suppliers." Proper storage under nitrogen atmosphere maintains optimal stability for critical coupling reactions.

The future trajectory for CAS 216393-67-8 appears robust, with market analysts projecting 6.8% CAGR for similar multi-halogenated intermediates through 2030. This growth connects to expanding applications in bioconjugation chemistry and catalytic C-H activation methodologies – both frequently searched topics in contemporary organic chemistry literature.

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