• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles Substituted imidazoles

4-(Hydroxymethyl)-1H-Imidazole-5-Carboxylic Acid: A Comprehensive Overview

The compound with CAS No. 215523-33-4, commonly referred to as 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid, is a significant molecule in the field of organic chemistry. This compound has garnered attention due to its unique structural properties and potential applications in various scientific domains. The imidazole ring at the core of this molecule plays a pivotal role in its reactivity and functionality, making it a subject of interest for researchers in drug discovery, material science, and biotechnology.

Recent studies have highlighted the importance of 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid in the development of novel therapeutic agents. The hydroxymethyl group attached to the imidazole ring introduces hydrophilic properties, enhancing its solubility and bioavailability. This feature is particularly advantageous in pharmaceutical applications, where molecular solubility is a critical factor for drug efficacy. Researchers have explored its potential as a precursor for synthesizing bioactive compounds, including antibiotics and anticancer agents.

The synthesis of 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid involves a multi-step process that typically begins with the preparation of imidazole derivatives. Advanced synthetic methodologies, such as microwave-assisted synthesis and catalytic cross-coupling reactions, have been employed to optimize the production process. These techniques not only improve yield but also ensure the purity of the final product, which is essential for downstream applications.

In terms of chemical properties, 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid exhibits a high degree of stability under physiological conditions. Its carboxylic acid group contributes to its acidic nature, making it suitable for use in buffering systems. Additionally, the molecule's ability to form hydrogen bonds enhances its interaction with biological macromolecules, such as proteins and nucleic acids, further broadening its applicability in biochemical research.

Recent advancements in computational chemistry have enabled researchers to perform detailed molecular modeling studies on 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid. These studies have provided insights into its electronic structure and reactivity patterns, facilitating the design of more efficient synthetic routes and potential drug candidates. For instance, molecular docking simulations have revealed promising binding affinities with key therapeutic targets, such as kinases and proteases.

The environmental impact of 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid has also been a topic of interest. Studies have shown that it undergoes biodegradation under aerobic conditions, minimizing its ecological footprint. This characteristic makes it an eco-friendly choice for use in green chemistry initiatives and sustainable manufacturing processes.

In conclusion, 4-(hydroxymethyl)-1H-imidazole-5-carboxylic acid (CAS No. 215523-33-4) is a versatile compound with diverse applications across multiple scientific disciplines. Its unique chemical properties and potential for further functionalization make it an invaluable tool for researchers striving to address complex scientific challenges. As ongoing research continues to uncover new insights into its capabilities, this compound is poised to play an increasingly important role in advancing modern science and technology.

• 1072-84-0(1H-Imidazole-4-carboxylic acid)
• 628296-60-6(1H-Imidazole-5-carboxylic acid, sodium salt (1:1))
• 1457-59-6(4-methyl-1H-imidazole-5-carboxylic acid)
• 78892-68-9(Methyl 4-methyl-1H-imidazole-5-carboxylate)
• 84255-25-4(1H-Imidazole-5-carboxylicacid, 2-ethyl-4-methyl-)
• 85110-06-1(methyl 4-formyl-1H-imidazole-5-carboxylate)
• 1457-58-5(2-methyl-1H-imidazole-5-carboxylic acid)
• 3304-70-9(4,5-dimethyl 1H-imidazole-4,5-dicarboxylate)
• 570-22-9(1H-Imidazole-4,5-dicarboxylic acid)
• 5313-35-9(2-Methyl-1H-imidazole-4,5-dicarboxylic acid)