Cas no 215305-98-9 (tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate)

Tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate is a protected amine derivative commonly used in organic synthesis and pharmaceutical research. Its key structural features include a tert-butoxycarbonyl (Boc) protecting group, which enhances stability and facilitates selective deprotection under mild acidic conditions. The piperidine-3-ethylamine backbone provides a versatile scaffold for further functionalization, making it valuable in the development of bioactive molecules. The Boc group ensures compatibility with a wide range of reaction conditions, improving synthetic efficiency. This compound is particularly useful in peptide chemistry and medicinal chemistry applications, where controlled amine reactivity is essential. Its high purity and well-defined reactivity profile make it a reliable intermediate for complex molecular constructions.
tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate structure
215305-98-9 structure
Product Name:tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate
CAS No:215305-98-9
MF:C12H24N2O2
MW:228.331163406372
MDL:MFCD01318364
CID:252944
PubChem ID:329775229
Update Time:2025-08-05

tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate Chemical and Physical Properties

Names and Identifiers

    • tert-Butyl (2-(piperidin-3-yl)ethyl)carbamate
    • 3-(2-BOC-AMINOETHYL) PIPERIDINE
    • 3-(N-Boc-aminoethyl)-piperidine
    • Carbamic acid, N-[2-(3-piperidinyl)ethyl]-, 1,1-dimethylethyl ester
    • N-Boc-piperidine-3-ethylamine
    • tert-Butyl 2-piperidin-3-ylethylcarbamate
    • tert-butyl N-(2-piperidin-3-ylethyl)carbamate
    • (2-piperidin-3-yl-ethyl)-carbamic acid tert-butyl ester
    • 3-(n-boc-2-aminoethyl)piperidine
    • tert-butyl (2-piperidin-3-ylethyl)carbamate(SALTDATA: FREE)
    • tert-butyl n-[2-(piperidin-3-yl)ethyl]carbamate
    • CHEMBL4575161
    • tert-butyl [2-(piperidin-3-yl)ethyl]carbamate
    • SY064285
    • tert.butyl (2-piperidin-3-yl-ethyl)-carbamate
    • tert-Butyl (2-piperidin-3-ylethyl)carbamate, AldrichCPR
    • AKOS000161157
    • SCHEMBL1009654
    • 3-(2-tert-Butoxycarbonylaminoethyl)piperidine
    • AB08697
    • CS-0002015
    • MFCD01318364
    • AC-6707
    • tert-butyl N-{2-[(3R)-piperidin-3-yl]ethyl}carbamate
    • tert-butyl 2-(piperidin-3-yl)ethylcarbamate
    • AS-36616
    • ALBB-005906
    • DTXSID40402387
    • tert-butyl (2-piperidin-3-ylethyl)carbamate
    • EN300-76327
    • tert-Butyl(2-(piperidin-3-yl)ethyl)carbamate
    • XQIKKZRRQGXGHF-UHFFFAOYSA-N
    • AKOS016342112
    • SB43327
    • 3-(2-boc-aminoethyl)piperidine
    • 3-(Boc-2-Aminoethyl)piperidine
    • 215305-98-9
    • STK503611
    • N-Boc-2-(3-piperidyl)ethanamine
    • 3-(N-Boc-aminoethyl)piperidine
    • tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate
    • MDL: MFCD01318364
    • Inchi: InChI=1S/C12H24N2O2/c1-12(2,3)16-11(15)14-8-6-10-5-4-7-13-9-10/h10,13H,4-9H2,1-3H3,(H,14,15)
    • InChI Key: XQIKKZRRQGXGHF-UHFFFAOYSA-N
    • SMILES: CC(C)(OC(NCCC1CCCNC1)=O)C

Computed Properties

  • Exact Mass: 228.18400
  • Monoisotopic Mass: 228.184
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 6
  • Complexity: 224
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 50.4A^2
  • XLogP3: 1.6

Experimental Properties

  • Color/Form: White to Yellow Solid
  • Density: 0.971
  • Boiling Point: 337.3°Cat760mmHg
  • Flash Point: 157.8°C
  • Refractive Index: 1.459
  • PSA: 50.36000
  • LogP: 2.62050

tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate Security Information

  • Signal Word:Warning
  • Hazard Statement: H302;H315;H319;H335
  • Warning Statement: P261;P305+P351+P338
  • Hazardous Material transportation number:NONH for all modes of transport
  • WGK Germany:3
  • HazardClass:IRRITANT
  • Storage Condition:2-8 °C

tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate Customs Data

  • HS CODE:2933399090
  • Customs Data:

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate

Professional Introduction to Compound with CAS No. 215305-98-9 and Product Name: tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate

The compound with the CAS number 215305-98-9 and the product name tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate represents a significant advancement in the field of pharmaceutical chemistry. This compound, characterized by its unique structural and functional properties, has garnered considerable attention in recent years due to its potential applications in drug development and therapeutic interventions.

At the core of this compound's significance lies its molecular structure, which integrates a tert-butyl group with a N-[2-(piperidin-3-yl)ethyl]carbamate moiety. The tert-butyl group contributes to the compound's stability and lipophilicity, making it an attractive candidate for oral administration and enhancing its bioavailability. Meanwhile, the N-[2-(piperidin-3-yl)ethyl]carbamate segment introduces a piperidine ring, a scaffold commonly found in bioactive molecules known for their ability to interact with biological targets. Piperidine derivatives are widely recognized for their role in modulating enzyme activity and receptor binding, which makes them invaluable in the design of novel therapeutic agents.

Recent research has highlighted the compound's potential in addressing various therapeutic challenges. Studies have demonstrated that derivatives of N-[2-(piperidin-3-yl)ethyl]carbamate exhibit promising pharmacological properties, including anti-inflammatory, analgesic, and neuroprotective effects. These findings have spurred further investigation into the compound's efficacy in treating conditions such as chronic pain syndromes, neurodegenerative diseases, and inflammatory disorders. The structural features of this compound allow it to engage with multiple biological pathways simultaneously, offering a multitargeted approach that could enhance therapeutic outcomes.

The incorporation of the tert-butyl group into the molecular framework also plays a crucial role in optimizing pharmacokinetic profiles. This bulky substituent can prevent rapid metabolism by enzymes such as cytochrome P450 (CYP450), thereby extending the compound's half-life and ensuring sustained therapeutic levels. Additionally, the lipophilic nature of the tert-butyl group facilitates efficient absorption across biological membranes, making it an ideal candidate for formulations requiring systemic delivery.

In vitro studies have revealed that tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate demonstrates remarkable binding affinity to specific enzymes and receptors implicated in various disease mechanisms. For instance, preliminary data suggest that this compound interacts with monoamine oxidase (MAO) enzymes, which are key players in regulating neurotransmitter levels. By modulating MAO activity, the compound may offer a novel strategy for managing conditions associated with neurotransmitter imbalances.

Moreover, the piperidine moiety within the molecule is known to enhance solubility and improve pharmacokinetic properties, which are critical factors in drug development. This feature allows for greater flexibility in formulation design and administration routes, broadening its potential applications across different therapeutic areas.

Current research is also exploring synthetic pathways to modify this compound further, aiming to enhance its selectivity and reduce potential side effects. By leveraging advanced chemical methodologies such as combinatorial chemistry and high-throughput screening (HTS), scientists are identifying structural analogs that may offer improved efficacy while maintaining safety profiles.

The pharmaceutical industry has taken note of these advancements, with several companies investing in clinical trials to evaluate the therapeutic potential of derivatives based on tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate. Early-phase trials have shown encouraging results, particularly in patients suffering from chronic pain conditions where traditional treatments have proven inadequate. These findings underscore the importance of innovative compounds like this one in addressing unmet medical needs.

From a regulatory perspective, ensuring compliance with international standards is paramount for advancing compounds like this into clinical practice. Regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have stringent guidelines for evaluating new drug candidates. Companies developing derivatives of tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate must navigate these requirements meticulously to bring safe and effective therapies to market.

The integration of computational modeling and artificial intelligence (AI) has further accelerated progress in optimizing this compound's properties. AI-driven platforms enable researchers to predict molecular interactions with high accuracy, facilitating rapid identification of promising candidates for further development. This synergy between traditional chemistry and cutting-edge technology is revolutionizing drug discovery processes.

In conclusion,tert-butyl N-[2-(piperidin-3-yl)ethyl]carbamate, represented by CAS No. 215305-98-9, holds immense promise as a versatile pharmacological entity with broad therapeutic applications. Its unique structural features make it an attractive scaffold for developing novel drugs targeting diverse diseases. As research continues to uncover new insights into its mechanisms of action, this compound is poised to play a pivotal role in shaping future medical treatments.

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