• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 4. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

3-Chloro-4-methylbenzonitrile (CAS No. 21423-81-4): An Overview of Its Properties, Applications, and Recent Research

3-Chloro-4-methylbenzonitrile (CAS No. 21423-81-4) is a versatile organic compound that has garnered significant attention in the fields of chemistry, pharmaceuticals, and materials science. This compound is characterized by its unique molecular structure, which consists of a benzene ring substituted with a chlorine atom at the 3-position and a methyl group at the 4-position, along with a cyano group attached to the benzene ring. The combination of these functional groups imparts distinct chemical and physical properties to 3-Chloro-4-methylbenzonitrile, making it a valuable intermediate in various synthetic processes.

The chemical formula of 3-Chloro-4-methylbenzonitrile is C₈H₆ClN, and it has a molecular weight of approximately 157.59 g/mol. The compound is typically a white to off-white crystalline solid at room temperature, with a melting point ranging from 67 to 70°C. It is slightly soluble in water but exhibits good solubility in organic solvents such as ethanol, acetone, and dichloromethane. These solubility properties make it suitable for use in a wide range of chemical reactions and processes.

In the realm of organic synthesis, 3-Chloro-4-methylbenzonitrile serves as an important building block for the synthesis of more complex molecules. Its reactivity is primarily centered around the cyano group, which can undergo various transformations such as hydrolysis to form carboxylic acids, reduction to form primary amines, and nucleophilic substitution reactions. These transformations are crucial in the development of pharmaceuticals, agrochemicals, and other fine chemicals.

One of the key applications of 3-Chloro-4-methylbenzonitrile is in the pharmaceutical industry. It is used as an intermediate in the synthesis of several drugs, including those with anti-inflammatory, analgesic, and antiviral properties. For instance, recent research has shown that derivatives of 3-Chloro-4-methylbenzonitrile exhibit potent activity against certain viral infections, making them promising candidates for the development of new antiviral therapies.

In addition to its pharmaceutical applications, 3-Chloro-4-methylbenzonitrile has also found use in materials science. Its unique electronic properties make it suitable for the synthesis of conductive polymers and other advanced materials. For example, studies have demonstrated that derivatives of 3-Chloro-4-methylbenzonitrile can be incorporated into polymer chains to enhance their electrical conductivity and mechanical strength. This has opened up new possibilities for applications in electronic devices and energy storage systems.

The environmental impact of 3-Chloro-4-methylbenzonitrile is another area of ongoing research. While it is generally considered safe for industrial use when proper handling protocols are followed, there is a growing interest in understanding its potential effects on ecosystems and human health. Recent studies have focused on evaluating the biodegradability and toxicity of this compound to ensure its safe use in various applications.

In conclusion, 3-Chloro-4-methylbenzonitrile (CAS No. 21423-81-4) is a multifaceted compound with a wide range of applications in chemistry, pharmaceuticals, and materials science. Its unique chemical structure and reactivity make it an invaluable intermediate in synthetic processes, contributing to the development of new drugs, advanced materials, and other innovative products. As research continues to uncover new possibilities for its use, 3-Chloro-4-methylbenzonitrile is likely to remain an important player in these fields.

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