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  Chan Seok Oh,Ha Lim Lee,Wan Pyo Hong,Jun Yeob Lee J. Mater. Chem. C 2019 7 7643
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt
• Catalysts and Inorganic Chemicals Inorganic Compounds

Introduction to (3-cyano-4-fluorophenyl)boronic Acid (CAS No. 214210-21-6)

(3-cyano-4-fluorophenyl)boronic acid), identified by its CAS number 214210-21-6, is a specialized boronic acid derivative that has garnered significant attention in the field of pharmaceutical chemistry and materials science. This compound, characterized by its unique structural features, including a cyano group at the 3-position and a fluorine atom at the 4-position of the phenyl ring, exhibits distinct chemical properties that make it valuable in various synthetic applications.

Boronic acids are well-known for their utility in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern organic synthesis. The presence of both electron-withdrawing and electron-donating groups in (3-cyano-4-fluorophenyl)boronic acid enhances its reactivity and selectivity, making it an excellent candidate for constructing complex molecular architectures. The cyano group introduces a strong electron-withdrawing effect, which can influence the electronic properties of the boronic acid moiety, while the fluorine atom provides additional steric and electronic modulation.

In recent years, there has been a surge in research focusing on boronic acid derivatives as pharmacophores and intermediates in drug development. The structural motif of (3-cyano-4-fluorophenyl)boronic acid has been explored in the design of novel therapeutic agents targeting various diseases. For instance, studies have demonstrated its potential in the synthesis of kinase inhibitors, where the precise arrangement of substituents can optimize binding affinity to biological targets.

The fluorine atom in (3-cyano-4-fluorophenyl)boronic acid not only enhances the compound's stability but also influences its metabolic pathways once incorporated into larger molecules. This feature is particularly relevant in drug design, where metabolic stability is a critical factor determining a drug's efficacy and safety profile. Recent advancements in computational chemistry have allowed researchers to predict how such substituents will interact with biological systems, further facilitating the development of targeted therapies.

One of the most compelling applications of (3-cyano-4-fluorophenyl)boronic acid lies in its role as a key intermediate in materials science. Boronic acids and their derivatives are widely used in the synthesis of polymers, coatings, and functional materials due to their ability to form stable complexes with various substrates. The unique electronic properties of this compound make it particularly useful in developing advanced materials with tailored optical and electronic characteristics.

The cyano group in (3-cyano-4-fluorophenyl)boronic acid also contributes to its utility in polymer chemistry by enabling further functionalization through reactions such as cyanation or hydrolysis. These transformations can lead to the creation of novel polymers with enhanced properties for specific applications, such as biodegradable plastics or high-performance composites. The combination of these chemical functionalities makes this compound a versatile building block for innovative material design.

In conclusion, (3-cyano-4-fluorophenyl)boronic acid (CAS No. 214210-21-6) represents a significant advancement in both pharmaceutical and materials science applications. Its unique structural features, including the presence of both cyano and fluorine substituents, endow it with exceptional reactivity and utility across multiple domains. As research continues to uncover new synthetic pathways and applications, this compound is poised to play an increasingly important role in shaping the future of chemical innovation.

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