• 1. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 2. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 3. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

2-(Carboxymethyl)Amino-1,3-Oxazole-5-Carboxylic Acid: A Comprehensive Overview

The compound with CAS No. 2137590-40-8, commonly referred to as 2-(carboxymethyl)amino-1,3-oxazole-5-carboxylic acid, is a fascinating molecule with significant potential in various scientific and industrial applications. This compound belongs to the class of heterocyclic compounds, specifically oxazoles, which are five-membered rings containing one nitrogen and two oxygen atoms. The presence of the carboxymethylamino group and the carboxylic acid moiety introduces unique chemical properties that make this compound a subject of interest in both academic and applied research.

Oxazole derivatives have been extensively studied due to their versatile reactivity and biological activity. The 2-(carboxymethyl)amino group in this compound adds a layer of complexity to its structure, enabling it to participate in various chemical reactions such as nucleophilic substitutions, condensations, and polymerizations. Recent studies have highlighted the potential of this compound in drug delivery systems, where its ability to form stable complexes with metal ions has been exploited for targeted drug release mechanisms.

The 1,3-oxazole ring in this molecule is known for its aromaticity and stability, which contribute to its resistance against harsh chemical conditions. This property makes it an ideal candidate for applications in high-performance materials such as polymers and coatings. For instance, researchers have reported the use of similar oxazole-containing compounds in the synthesis of advanced polymers with enhanced thermal stability and mechanical strength.

One of the most promising areas of research involving 2-(carboxymethyl)amino-1,3-oxazole-5-carboxylic acid is its role in biochemistry and pharmacology. The carboxylic acid group at position 5 allows for easy functionalization, enabling the molecule to serve as a versatile building block in medicinal chemistry. Recent advancements have demonstrated its potential as a lead compound in the development of anti-inflammatory agents and anticancer drugs. Its ability to inhibit key enzymes involved in inflammatory pathways has drawn significant attention from pharmaceutical researchers.

In addition to its therapeutic applications, this compound has also found utility in analytical chemistry as a chelating agent. The carboxymethylamino group enables it to form strong complexes with metal ions such as copper(II) and iron(III), making it valuable in trace metal analysis and purification processes. This property has been leveraged in environmental monitoring applications, where accurate detection of heavy metals is critical for pollution control.

From a synthetic perspective, the preparation of 2-(carboxymethyl)amino-1,3-oxazole-5-carboxylic acid involves a multi-step process that typically begins with the synthesis of the oxazole ring followed by functionalization at specific positions. Recent innovations in catalytic methods have significantly improved the yield and purity of this compound, making it more accessible for large-scale production.

Looking ahead, the continued exploration of 2-(carboxymethyl)amino-1,3-oxazole-5-carboxylic acid is expected to uncover new applications across diverse fields. Its unique combination of structural features positions it as a valuable tool in both basic research and industrial development. As researchers delve deeper into its properties and potential uses, this compound is poised to play an increasingly important role in advancing scientific knowledge and technological innovation.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)