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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles 2,5-disubstituted thiazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles 2,5-disubstituted thiazoles

2-(Pyridin-4-yl)-1,3-thiazole-5-carbaldehyde (CAS No. 21346-36-1): A Comprehensive Overview

2-(Pyridin-4-yl)-1,3-thiazole-5-carbaldehyde, also known by its CAS registry number CAS No. 21346-36-1, is a heterocyclic compound with significant potential in various fields of chemistry and materials science. This compound belongs to the class of thiazoles, which are five-membered aromatic rings containing sulfur and nitrogen atoms. The presence of a pyridine ring attached to the thiazole structure introduces unique electronic properties, making it a subject of interest for researchers in drug discovery, material synthesis, and catalysis.

The molecular structure of 2-(Pyridin-4-yl)-1,3-thiazole-5-carbaldehyde consists of a thiazole ring fused with a pyridine moiety and an aldehyde group at the 5-position. This arrangement creates a conjugated system that enhances its stability and reactivity. Recent studies have highlighted its role as a building block in the synthesis of advanced materials, such as metal-organic frameworks (MOFs) and coordination polymers. The aldehyde group serves as a versatile functional group, enabling further chemical modifications to tailor the compound's properties for specific applications.

In terms of physical properties, CAS No. 21346-36-1 exhibits a high melting point due to its rigid aromatic structure and strong intermolecular interactions. Its solubility in organic solvents makes it suitable for use in organic synthesis reactions. The compound's UV-vis absorption spectrum shows strong absorbance in the visible region, which is attributed to the extended conjugation within the molecule. This property has been exploited in the development of sensors and optoelectronic devices.

Recent advancements in synthetic chemistry have led to efficient methods for the preparation of 2-(Pyridin-4-yl)-1,3-thiazole-5-carbaldehyde. One such method involves the cyclization of an appropriate aldoxime intermediate under acidic conditions. This approach not only simplifies the synthesis but also allows for the incorporation of additional functional groups to enhance its reactivity and functionality.

The application of CAS No. 21346-36-1 extends beyond traditional chemical synthesis. It has been employed as a ligand in transition metal catalysis, where its ability to coordinate with metal centers facilitates various catalytic transformations. For instance, palladium-catalyzed cross-coupling reactions using this compound as a ligand have shown improved yields and selectivity compared to conventional ligands.

In the field of materials science, 2-(Pyridin-4-y) has been used as a precursor for constructing two-dimensional (2D) materials and porous networks. Its ability to form coordination bonds with metal ions enables the creation of hierarchical architectures with tunable pore sizes and surface areas. These materials hold promise for applications in gas storage, separation, and catalysis.

Moreover, recent research has explored the biological activity of CAS No. 21346-36

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• 892502-19-1(4-methyl-2-(pyridin-4-yl)-1,3-thiazole-5-carbaldehyde)
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• 721920-84-9(2-(4-Chlorophenyl)thiazole-5-carbaldehyde)
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