• 1. A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects
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• 2. Catalyst free synthesis of α-fluoro-β-hydroxy ketones/α-fluoro-ynols via electrophilic fluorination of tertiary propargyl alcohols using Selectfluor? (F-TEDA-BF4)
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzophenones
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

Professional Introduction to 4-Benzoylbiphenyl (CAS No. 2128-93-0)

4-Benzoylbiphenyl, a compound with the chemical identifier CAS No. 2128-93-0, is a significant molecule in the field of organic chemistry and pharmaceutical research. This aromatic compound, characterized by its biphenyl core substituted with a benzoyl group at the para position, has garnered attention due to its unique structural and functional properties. The benzoyl group introduces specific electronic and steric effects that make 4-benzoylbiphenyl a valuable intermediate in the synthesis of various pharmacologically active agents.

The structural motif of 4-benzoylbiphenyl consists of two phenyl rings connected by a single carbon-carbon bond, with one of the rings bearing a benzoyl substituent. This arrangement imparts distinct chemical reactivity and potential biological activity, making it a subject of extensive interest in medicinal chemistry. The compound's stability and the ease with which it can undergo further functionalization make it a versatile building block in the development of novel therapeutic agents.

In recent years, researchers have been exploring the potential applications of 4-benzoylbiphenyl in various domains, particularly in the development of small-molecule drugs. Its biphenyl core is known to enhance binding affinity and selectivity when incorporated into drug molecules, which is crucial for achieving therapeutic efficacy while minimizing side effects. Furthermore, the benzoyl group can serve as a handle for further chemical modifications, allowing for the creation of derivatives with tailored properties.

One of the most compelling aspects of 4-benzoylbiphenyl is its role in the synthesis of bioactive compounds. For instance, studies have demonstrated its utility in constructing molecules that interact with specific biological targets, such as enzymes and receptors. These interactions are often key to modulating cellular processes and treating diseases. The compound's ability to serve as a scaffold for drug design has led to several promising candidates entering preclinical development.

The pharmacological potential of 4-benzoylbiphenyl has been further supported by recent research findings. A notable study published in Journal of Medicinal Chemistry highlighted its application in developing inhibitors for certain enzymes involved in metabolic pathways relevant to inflammation and cancer. The study demonstrated that derivatives of 4-benzoylbiphenyl could effectively modulate enzyme activity, suggesting their therapeutic potential in treating these conditions.

Another area where 4-benzoylbiphenyl has shown promise is in the field of materials science. Its rigid aromatic structure makes it an excellent candidate for applications requiring high thermal stability and mechanical strength. Researchers have explored its use in creating advanced polymers and coatings that exhibit superior performance characteristics. These materials could find applications in electronics, aerospace, and automotive industries, where reliability and durability are paramount.

The synthesis of 4-benzoylbiphenyl is another area that has seen significant advancements. Modern synthetic methodologies have enabled more efficient and scalable production processes, making it more accessible for research and industrial applications. Techniques such as palladium-catalyzed cross-coupling reactions have been particularly useful in constructing the biphenyl core with high precision. These improvements have not only enhanced the yield but also reduced the environmental impact of its production.

The future prospects for 4-benzoylbiphenyl are vast and multifaceted. As our understanding of its chemical properties continues to grow, so does its potential for innovation across multiple disciplines. Whether it is through developing new pharmaceuticals or creating advanced materials, this compound stands at the forefront of scientific discovery. The ongoing research efforts aim to unlock even more possibilities, ensuring that 4-benzoylbiphenyl remains a cornerstone in both academic and industrial settings.

In conclusion, 4-benzoylbiphenyl (CAS No. 2128-93-0) is a compound of considerable interest due to its unique structure and versatile applications. Its role as an intermediate in drug development and a material science component underscores its importance in modern chemistry. As research progresses, we can expect even more groundbreaking applications to emerge, solidifying its place as a key player in scientific advancement.

• 3478-90-8(4,4'-Diphenylbenzophenone)
• 33090-29-8(Methanone, [1,1'-biphenyl]-4,4'-diylbis[phenyl-)
• 227099-60-7(Methanone,1,1'-[5'-(4-benzoylphenyl)[1,1':3',1''-terphenyl]-4,4''-diyl]bis[1-phenyl-)
• 5748-38-9(4-Acetyl-4'-Methylbiphenyl)
• 3112-01-4(Ethanone,1-[1,1'-biphenyl]-3-yl-)
• 787-69-9(4,4'-Diacetylbiphenyl)
• 5730-92-7(Ethanone,1-(4'-ethyl[1,1'-biphenyl]-4-yl)-)
• 92-91-1(4-Acetylbiphenyl)
• 63283-56-7(Methanone, (4'-methyl[1,1'-biphenyl]-4-yl)phenyl-)
• 3378-09-4(1,1'-Biphenyl-3-yl(phenyl)methanone)