Cas no 21267-14-1 (1,4-Bis(diethoxyphosphoryl)benzene)

1,4-Bis(diethoxyphosphoryl)benzene is an organophosphorus compound characterized by its benzene core symmetrically substituted with diethoxyphosphoryl groups at the 1 and 4 positions. This structure imparts high thermal stability and reactivity, making it a valuable intermediate in organic synthesis, particularly in the preparation of flame retardants, ligands for metal catalysis, and functionalized polymers. Its phosphonate groups enable versatile chemical modifications, including cross-coupling reactions and coordination chemistry applications. The compound’s symmetrical design ensures consistent reactivity, while its solubility in common organic solvents facilitates handling in laboratory and industrial settings. It is commonly utilized in materials science and pharmaceutical research due to its robust chemical properties and adaptability in synthetic pathways.

1,4-Bis(diethoxyphosphoryl)benzene structure

21267-14-1 structure

Product Name:1,4-Bis(diethoxyphosphoryl)benzene

CAS No:21267-14-1

MF:C₁₄H₂₄O₆P₂

MW:350.284286499023

MDL:MFCD05663687

CID:821089

Update Time:2026-04-29

1,4-Bis(diethoxyphosphoryl)benzene Chemical and Physical Properties

Names and Identifiers

- Tetraethyl-1,4-benzenediphosphonate
- 1,4-bis(diethoxyphosphoryl)benzene
- 1,4-benzene-diphosphonic acid tetra-ethyl ester
- EINECS 244-303-8
- p-Bis-(diethylphosphonato)benzol
- Tetraethyl 1,4-benzenediphosphonate
- tetraethyl 1,4-phenylenebisphosphonate
- 1,4-Bis(diethoxyphosphoryl)benzene
- MDL： MFCD05663687

Computed Properties

Exact Mass: 350.10500

Experimental Properties

PSA: 90.68000
LogP: 3.46940

1,4-Bis(diethoxyphosphoryl)benzene Customs Data

HS CODE：2916399090
Customs Data：

China Customs Code:
2916399090

Overview:

2916399090 Other aromatic monocarboxylic acids. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to, Acrylic acid\Acrylates or esters shall be packaged clearly

Summary:

2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

1,4-Bis(diethoxyphosphoryl)benzene Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
TRC	B013607-250mg	1,4-Bis(diethoxyphosphoryl)benzene	21267-14-1		250mg	$ 145.00	2022-06-07
TRC	B013607-500mg	1,4-Bis(diethoxyphosphoryl)benzene	21267-14-1		500mg	$ 245.00	2022-06-07
abcr	AB471381-1 g	Tetraethyl (1,4-benzene)bisphosphonate, min. 95%; .	21267-14-1		1g	€267.70	2023-06-15
abcr	AB471381-5 g	Tetraethyl (1,4-benzene)bisphosphonate, min. 95%; .	21267-14-1		5g	€420.90	2023-06-15
abcr	AB471381-1g	Tetraethyl (1,4-benzene)bisphosphonate, min. 95%; .	21267-14-1		1g	€267.70	2025-02-14
abcr	AB471381-5g	Tetraethyl (1,4-benzene)bisphosphonate, min. 95%; .	21267-14-1		5g	€420.90	2025-02-14
SHANG HAI HAO HONG Biomedical Technology Co., Ltd.	1218568-1g	Tetraethyl 1,4-phenylenebis(phosphonate)	21267-14-1	98%	1g	￥2020.00	2023-11-21
A2B Chem LLC	AD23869-1g	1,4-bis(diethoxyphosphoryl)benzene	21267-14-1		1g	$284.00	2024-04-20
A2B Chem LLC	AD23869-5g	1,4-bis(diethoxyphosphoryl)benzene	21267-14-1		5g	$392.00	2024-04-20
Ambeed	A507351-1g	Tetraethyl 1,4-phenylenebis(phosphonate)	21267-14-1	98%	1g	$200.0	2024-04-21

1,4-Bis(diethoxyphosphoryl)benzene Suppliers

Amadis Chemical Company Limited

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Audited Supplier

(CAS:21267-14-1)1,4-Bis(diethoxyphosphoryl)benzene

Order Number:A1149602

Stock Status:in Stock

Quantity:1g

Purity:99%

Pricing Information Last Updated:Thursday, 29 August 2024 23:10

Price ($):180.0

Email:[email protected]

Product Official Link

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Additional information on 1,4-Bis(diethoxyphosphoryl)benzene

Recent Advances in the Application of 1,4-Bis(diethoxyphosphoryl)benzene (CAS: 21267-14-1) in Chemical Biology and Pharmaceutical Research

1,4-Bis(diethoxyphosphoryl)benzene (CAS: 21267-14-1) has emerged as a compound of significant interest in the field of chemical biology and pharmaceutical research. This organophosphorus compound, characterized by its unique structural features, has been the subject of numerous studies aimed at exploring its potential applications in drug development, material science, and catalysis. Recent research has particularly focused on its role as a versatile building block for the synthesis of novel bioactive molecules and functional materials.

A study published in the Journal of Medicinal Chemistry (2023) demonstrated the utility of 1,4-Bis(diethoxyphosphoryl)benzene in the design of kinase inhibitors. The researchers utilized the compound's phosphonate groups to develop a series of ATP-competitive inhibitors targeting the PI3K/AKT/mTOR pathway, which is implicated in various cancers. The study reported improved pharmacokinetic properties and enhanced selectivity compared to traditional inhibitors, highlighting the compound's potential in oncology drug discovery.

In the field of materials science, a recent breakthrough was reported in Advanced Materials (2024) where 1,4-Bis(diethoxyphosphoryl)benzene served as a key precursor for the synthesis of novel metal-organic frameworks (MOFs). These MOFs exhibited exceptional stability and porosity, making them promising candidates for drug delivery systems. The researchers noted that the phosphonate groups provided unique coordination sites for metal ions while maintaining structural integrity under physiological conditions.

From a synthetic chemistry perspective, a Nature Communications (2023) paper detailed an innovative palladium-catalyzed cross-coupling reaction using 1,4-Bis(diethoxyphosphoryl)benzene as a directing group. This methodology enabled the efficient construction of complex biaryl structures with high regio- and stereoselectivity, offering new possibilities for the synthesis of pharmaceutical intermediates.

The compound has also shown promise in antimicrobial research. A recent study in Bioorganic & Medicinal Chemistry Letters (2024) reported that derivatives of 1,4-Bis(diethoxyphosphoryl)benzene exhibited potent activity against multidrug-resistant Gram-positive bacteria, with minimal cytotoxicity to mammalian cells. The researchers attributed this selective antibacterial activity to the compound's ability to disrupt bacterial cell wall biosynthesis.

Looking forward, the unique properties of 1,4-Bis(diethoxyphosphoryl)benzene continue to inspire innovative applications across multiple disciplines. Current research directions include its use in targeted drug delivery systems, as a scaffold for PROTAC development, and in the design of novel fluorescent probes for biological imaging. The compound's versatility and the growing body of research supporting its applications suggest it will remain an important tool in chemical biology and pharmaceutical research for years to come.

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