Cas no 21203-78-1 (2-Bromo-6-nitropyridine)

2-Bromo-6-nitropyridine is a halogenated nitropyridine derivative commonly employed as a versatile intermediate in organic synthesis and pharmaceutical research. Its distinct bromo and nitro functional groups at the 2- and 6-positions of the pyridine ring enable selective substitution reactions, facilitating the construction of complex heterocyclic frameworks. This compound is particularly valuable in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, due to the reactivity of the bromo substituent. The electron-withdrawing nitro group further enhances its utility in nucleophilic aromatic substitution and reduction reactions. With high purity and consistent performance, 2-Bromo-6-nitropyridine is a reliable building block for the development of agrochemicals, pharmaceuticals, and specialty materials.
2-Bromo-6-nitropyridine structure
2-Bromo-6-nitropyridine structure
Product Name:2-Bromo-6-nitropyridine
CAS No:21203-78-1
MF:C5H3BrN2O2
MW:202.993520021439
MDL:MFCD00234012
CID:51743
PubChem ID:1415846
Update Time:2025-05-20

2-Bromo-6-nitropyridine Chemical and Physical Properties

Names and Identifiers

    • 2-Bromo-6-nitropyridine
    • Pyridine,2-bromo-6-nitro
    • MDL: MFCD00234012
    • Inchi: 1S/C5H3BrN2O2/c6-4-2-1-3-5(7-4)8(9)10/h1-3H
    • InChI Key: JULQLOHNPMMKTH-UHFFFAOYSA-N
    • SMILES: BrC1=CC=CC([N+](=O)[O-])=N1

Computed Properties

  • Exact Mass: 201.93800
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1

Experimental Properties

  • PSA: 58.71000
  • LogP: 2.27550

2-Bromo-6-nitropyridine Security Information

2-Bromo-6-nitropyridine Customs Data

  • HS CODE:2933399090
  • Customs Data:

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-Bromo-6-nitropyridine Production Method

2-Bromo-6-nitropyridine Related Literature

Additional information on 2-Bromo-6-nitropyridine

2-Bromo-6-nitropyridine (CAS No. 21203-78-1): Properties, Applications, and Market Insights

2-Bromo-6-nitropyridine (CAS No. 21203-78-1) is a versatile heterocyclic compound widely used in pharmaceutical and agrochemical research. This yellow crystalline solid belongs to the pyridine derivative family, featuring both bromine and nitro functional groups. Its unique structure makes it a valuable intermediate in organic synthesis, particularly in the development of bioactive molecules.

The molecular formula of 2-bromo-6-nitropyridine is C5H3BrN2O2, with a molecular weight of 202.99 g/mol. Recent studies highlight its growing importance in medicinal chemistry, especially in the design of kinase inhibitors and antimicrobial agents. Researchers are particularly interested in its nitropyridine derivatives for their potential in drug discovery programs targeting various diseases.

In the pharmaceutical industry, 2-Bromo-6-nitropyridine synthesis has gained attention due to its role in creating novel therapeutic compounds. The compound's reactivity allows for various substitution reactions, making it a crucial building block for more complex molecules. Current trends show increased demand for halogenated nitropyridines in the development of next-generation pharmaceuticals.

The agrochemical sector utilizes 2-Bromo-6-nitropyridine CAS 21203-78-1 in the production of crop protection agents. Its structural features contribute to the biological activity of certain pesticides and herbicides. Recent innovations in sustainable agriculture have driven research into more efficient synthesis methods for this compound.

From a commercial perspective, the global market for nitropyridine compounds is experiencing steady growth. Manufacturers are focusing on improving production processes to meet the rising demand from research institutions and industrial applications. Quality specifications for 2-bromo-6-nitropyridine supplier materials have become more stringent, reflecting its importance in high-value applications.

Analytical characterization of 2-Bromo-6-nitropyridine typically involves techniques such as HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure purity and verify structural integrity for research purposes. The compound's stability under various conditions makes it suitable for diverse synthetic applications.

Environmental considerations regarding halogenated pyridine derivatives have prompted studies on their biodegradation pathways. While 2-Bromo-6-nitropyridine itself shows moderate environmental persistence, researchers are developing greener alternatives for certain applications without compromising performance.

In material science, nitropyridine-based compounds are being explored for their potential in organic electronics. The electron-withdrawing nature of both the nitro and bromo groups in 2-Bromo-6-nitropyridine makes it interesting for designing novel conductive materials and photoactive components.

Safety protocols for handling 2-Bromo-6-nitropyridine 21203-78-1 emphasize proper personal protective equipment and ventilation. While not classified as highly hazardous, standard precautions for laboratory chemicals apply. Material safety data sheets provide detailed guidance for researchers working with this compound.

The future outlook for 2-Bromo-6-nitropyridine applications appears promising, with ongoing research uncovering new potential uses. Its role in developing innovative pharmaceuticals and agrochemicals continues to expand, supported by advances in synthetic methodology and process optimization.

For researchers seeking 2-Bromo-6-nitropyridine suppliers, it's essential to verify certificates of analysis and purity specifications. The compound is typically available in laboratory-scale quantities from specialty chemical providers, with custom synthesis options for specific research needs.

Recent patent literature reveals growing interest in 2-Bromo-6-nitropyridine derivatives across multiple industries. Innovations in catalytic processes for its production are reducing costs and improving yields, making this compound more accessible for various applications.

Academic investigations into nitropyridine chemistry frequently utilize 2-Bromo-6-nitropyridine as a model compound. Its well-defined reactivity patterns make it valuable for teaching advanced organic synthesis techniques and reaction mechanisms.

The price trends for 2-Bromo-6-nitropyridine CAS 21203-78-1 reflect its specialized nature, with fluctuations based on raw material availability and production scale. Bulk purchasing options are becoming more common as industrial applications increase.

Quality control measures for 2-Bromo-6-nitropyridine include rigorous testing for impurities and byproducts. Advanced analytical techniques ensure consistency between batches, which is critical for reproducible research results and industrial processes.

Storage recommendations for 2-bromo-6-nitropyridine chemical typically suggest cool, dry conditions away from strong oxidizers. Proper labeling and containment prevent degradation and maintain material integrity over extended periods.

Emerging applications of 2-Bromo-6-nitropyridine in catalysis and materials science demonstrate the compound's versatility beyond its traditional uses. Researchers are discovering new reaction pathways that leverage its unique electronic properties.

The scientific community continues to explore nitropyridine scaffold modifications using 2-Bromo-6-nitropyridine as a starting material. These investigations contribute to the broader understanding of heterocyclic chemistry and its practical applications.

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