• 1. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 2. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

Professional Introduction of 2,3,4-Trichlorobenzonitrile (CAS No. 2112-31-4)

2,3,4-Trichlorobenzonitrile, also known by its CAS registry number 2112-31-4, is a chlorinated aromatic nitrile compound that has garnered significant attention in various fields of scientific research and industrial applications. This compound belongs to the family of aromatic heterocyclic compounds, characterized by its unique structure featuring three chlorine substituents on a benzene ring attached to a cyano group (-CN). The combination of electron-withdrawing groups (the chlorine atoms and the nitrile group) renders this compound highly reactive and versatile in chemical transformations.

Over the years, 2,3,4-trichlorobenzonitrile has been extensively studied for its potential applications in pharmaceuticals, agrochemicals, and materials science. Recent studies have highlighted its role as an intermediate in the synthesis of bioactive molecules, including cancer therapeutic agents and antimicrobial compounds. Its structural features make it an ideal precursor for constructing complex heterocyclic frameworks, which are often critical in drug discovery.

In the realm of pharmaceutical research, 2,3,4-trichlorobenzonitrile has been explored as a building block for the development of cytotoxic agents. For instance, its derivatives have demonstrated promising activity against various cancer cell lines, particularly in targeting proliferative signaling pathways. The presence of multiple chlorine atoms enhances the compound's ability to undergo nucleophilic substitution reactions, making it a valuable intermediate for constructing diverse pharmacophores.

Another area where 2,3,4-trichlorobenzonitrile has found significant application is in agrochemicals. The compound's nitrile group and halogen substituents contribute to its herbicidal activity, particularly against broadleaf weeds. Recent advancements in crop protection have emphasized the development of environmentally sustainable agrochemicals, and 2,3,4-trichlorobenzonitrile continues to be a subject of interest due to its selective weed control properties.

Beyond pharmaceuticals and agrochemicals, this compound has also been utilized in the synthesis of advanced materials. Its structural versatility allows for the creation of functional polymers and coatings with unique electronic and mechanical properties. For example, derivatives of 2,3,4-trichlorobenzonitrile have been incorporated into polymer matrices to enhance thermal stability and conductivity, making them suitable for applications in electronics and energy storage.

Recent studies have also explored the potential of 2,3,4-trichlorobenzonitrile in catalytic processes. Its ability to act as both an electron-deficient aromatic ring and a nitrile group provides unique opportunities for designing catalysts with tailored properties. For instance, researchers have investigated its role in nitration reactions and cross-coupling transformations, where it serves as a highly reactive intermediate.

In terms of environmental impact, the compound's stability and reactivity make it both a challenge and an opportunity. While its persistence in the environment requires careful consideration, ongoing research focuses on optimizing its use to minimize ecological footprint. Innovations in green chemistry aim to leverage the compound's properties while ensuring sustainable practices.

The synthesis of 2,3,4-trichlorobenzonitrile involves several steps, typically starting from chlorobenzene derivatives and introducing the nitrile group through various substitution reactions. Modern synthetic methods have improved the efficiency and selectivity of these processes, reducing byproducts and enhancing yield.

In conclusion, 2,3,4-trichlorobenzonitrile (CAS No. 2112-31-4) stands as a crucial compound in the arsenal of organic chemistry. Its diverse applications across pharmaceuticals, agrochemicals, and materials science underscore its significance in both academic research and industrial innovation. As scientific advancements continue to unlock new possibilities, this compound will remain at the forefront of efforts to develop life-saving drugs, sustainable agrochemicals, and cutting-edge materials.

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