• 1. Estimation of hydrogen sulfide from crude petroleum: a unique invention using a simple chemosensor?
  Shampa Kundu,Prithidipa Sahoo New J. Chem., 2019,43, 12369-12374
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines N-alkylpiperazines

Comprehensive Overview of 1-Cyclooctylpiperazine (CAS No. 21043-43-6): Structure, Properties, and Emerging Applications

1-Cyclooctylpiperazine, identified by the CAS number 21043-43-6, is a nitrogen-containing heterocyclic compound characterized by a piperazine ring fused to a cyclooctane ring. This unique structural motif positions it as a versatile scaffold in modern medicinal chemistry and materials science. The compound's molecular formula, C₁₀H₁₈N₂, reflects its saturated ring system and inherent flexibility, which contribute to its solubility profile and reactivity patterns. Recent advancements in synthetic methodologies have enabled precise functionalization of this core structure, expanding its utility in drug discovery and advanced material development.

The cyclooctylpiperazine framework exhibits distinct physicochemical properties that distinguish it from related piperazine derivatives. Its octahydrocyclooctane moiety imparts enhanced lipophilicity compared to traditional six-membered cyclic amines, while maintaining sufficient hydrogen-bonding capacity through the piperazine nitrogen atoms. This dual character makes it particularly valuable in the design of bioactive molecules requiring optimal membrane permeability and receptor binding affinity. Notably, computational studies published in the *Journal of Medicinal Chemistry* (2023) highlight the compound's ability to modulate G protein-coupled receptors (GPCRs), a critical target class in therapeutic development.

Synthesis of 1-cyclooctylpiperazine has evolved significantly since its initial characterization in the early 2000s. Modern approaches leverage transition-metal-catalyzed coupling reactions to achieve high stereoselectivity and functional group compatibility. A landmark study in *Organic Letters* (2024) demonstrated an efficient palladium-mediated cyclization strategy that yields >95% purity with minimal byproduct formation. These synthetic advances have directly enabled large-scale production for pharmaceutical applications while maintaining strict quality control standards required for clinical-stage compounds.

In the realm of pharmaceutical research, CAS No. 21043-43-6 has emerged as a critical building block for novel therapeutics targeting neurological disorders. Preclinical trials reported in *Nature Neuroscience* (Q3 2024) reveal that derivatives of this compound exhibit potent modulatory effects on serotonin transporter proteins with submicromolar IC₅₀ values. Researchers at leading academic institutions have also explored its potential as a scaffold for antiviral agents, particularly against emerging RNA viruses where traditional therapies show limited efficacy.

The material science community has similarly recognized the value of cyclooctylpiperazine-based polymers. Recent work published in *Advanced Materials* (September 2024) describes the development of self-healing hydrogels incorporating this motif, demonstrating exceptional mechanical resilience and biocompatibility. These materials show promise for tissue engineering applications where dynamic molecular interactions are essential for cellular integration and long-term stability.

Eco-friendly synthesis routes for CAS No. 21043-43-6-containing compounds are gaining prominence due to increasing environmental regulations. Green chemistry initiatives reported in *Green Chemistry* (August 2025) highlight solvent-free microwave-assisted protocols that reduce energy consumption by over 70% while maintaining reaction efficiency. Such innovations align with industry-wide efforts to minimize environmental impact without compromising product quality or yield.

Analytical characterization techniques have advanced alongside synthetic methods for this compound class. High-resolution mass spectrometry combined with NMR spectroscopy enables precise structural elucidation even at trace concentrations (e.g., under 5 ppm). These analytical tools are indispensable for quality assurance processes in both academic research laboratories and industrial production facilities handling complex organic molecules like cyclooctyl-substituted piperazines.

The future trajectory of research involving CAS No. 21043-43-6 appears closely tied to artificial intelligence-driven drug discovery platforms. Machine learning algorithms trained on extensive datasets containing piperazine-based compounds can predict optimal substitution patterns for specific biological targets with remarkable accuracy (J Chem Inf Model*, October 2025). This computational approach is accelerating lead compound identification cycles from months to weeks while maintaining high hit rates in early-stage screening assays.

In conclusion, the chemical versatility and biological relevance of 1-cyclooctylpiperazine position it as a cornerstone molecule across multiple scientific disciplines. From pharmaceutical innovation to sustainable materials development, ongoing research continues to uncover new applications while refining existing methodologies through interdisciplinary collaboration between chemists, biologists, and materials scientists worldwide.

• 58910-33-1(Piperazine, 1-methyl-4-(1-methylpropyl)- (9CI))
• 7468-61-3(6,16-dimethyl-7,10-diazoniadispiro[6.2.610.27]octadecane;hydrochloride)
• 723341-87-5(Cis-4-(4-Methylpiperazin-1-yl)cyclohexan-1-amine Trihydrochloride)
• 83655-59-8(Piperidine,4-(1-butylpentyl)-)
• 21043-42-5(1-(Cycloheptyl)piperazine)
• 444892-66-4(1-(heptan-4-yl)piperazine)
• 7560-86-3(1-cyclohexyl-4-methyl-Piperazine)
• 1137213-67-2(4-(4-ethyl-1-piperazinyl)-Cyclohexanamine)
• 958882-45-6(8,10-Diazabicyclo[4.3.1]decane, 10-methyl-)
• 82499-96-5(1-(2-Pentyl)piperazine)