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  Nathalie Berthet,Véronique Martel-Frachet,Fabien Michel,Christian Philouze,Sylvain Hamman,Xavier Ronot,Fabrice Thomas Dalton Trans. 2013 42 8468
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-pyridylmethylamines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

Introduction to 2-(Methylamino)methylpyridine (CAS No. 21035-59-6)

2-(Methylamino)methylpyridine, also known as 2-(methylaminomethyl)pyridine or 2-(N-methylaminomethyl)pyridine, is a versatile organic compound with the chemical formula C₈H₁₁N₂. This compound is characterized by its pyridine ring structure with a methylaminomethyl group attached at the 2-position. Its unique chemical structure and properties make it an important intermediate in various synthetic pathways and applications, particularly in the fields of pharmaceuticals, agrochemicals, and materials science.

The compound is listed under the Chemical Abstracts Service (CAS) registry with the number 21035-59-6. This registration number is crucial for identifying and tracking the compound in scientific literature, regulatory documents, and commercial databases. The CAS number ensures that researchers and industry professionals can easily reference and access accurate information about the compound's properties, synthesis methods, and applications.

2-(Methylamino)methylpyridine is a colorless to pale yellow liquid with a characteristic odor. It is soluble in common organic solvents such as ethanol, acetone, and dichloromethane. The compound's solubility and reactivity make it an ideal starting material for a wide range of chemical transformations. Its basic nature, due to the presence of the pyridine ring and the amino group, allows it to participate in various acid-base reactions and coordination chemistry.

In recent years, significant advancements have been made in understanding the synthetic utility of 2-(Methylamino)methylpyridine. One notable application is its use as a building block in the synthesis of bioactive molecules. For instance, a study published in the Journal of Medicinal Chemistry highlighted the role of this compound in the development of novel antiviral agents. The researchers demonstrated that derivatives of 2-(Methylamino)methylpyridine exhibited potent antiviral activity against several strains of influenza virus, making it a promising lead for further drug development.

Beyond its pharmaceutical applications, 2-(Methylamino)methylpyridine has also found use in the synthesis of agrochemicals. A recent study in Pesticide Biochemistry and Physiology explored its potential as an intermediate in the production of herbicides and insecticides. The researchers found that certain derivatives of this compound showed enhanced efficacy against common agricultural pests, suggesting its potential for developing more effective and environmentally friendly pest control solutions.

In materials science, 2-(Methylamino)methylpyridine has been investigated for its role in the synthesis of functional polymers and coordination complexes. A study published in Macromolecules reported the use of this compound as a ligand in the preparation of metal-organic frameworks (MOFs). The resulting MOFs exhibited high surface areas and tunable porosity, making them suitable for applications such as gas storage, catalysis, and drug delivery systems.

The synthetic versatility of 2-(Methylamino)methylpyridine is further enhanced by its ability to undergo various chemical transformations. For example, it can be readily converted into N-alkylated derivatives through reactions with alkyl halides or via reductive alkylation using formaldehyde. These derivatives often exhibit improved solubility and stability compared to the parent compound, which can be advantageous in certain applications.

In addition to its synthetic utility, 2-(Methylamino)methylpyridine has been studied for its biological activities. Research published in Bioorganic & Medicinal Chemistry Letters investigated its potential as a scaffold for developing inhibitors of specific enzymes involved in disease pathways. The study found that certain derivatives of this compound showed selective inhibition of key enzymes related to cancer progression and neurodegenerative diseases.

The environmental impact of chemicals used in various industries is an increasingly important consideration. Studies have shown that 2-(Methylamino)methylpyridine can be synthesized using green chemistry principles, which aim to minimize environmental harm during production processes. For example, a recent paper in Green Chemistry described a method for synthesizing this compound using mild conditions and renewable resources, reducing waste generation and energy consumption.

In conclusion, 2-(Methylamino)methylpyridine (CAS No. 21035-59-6) is a valuable compound with a wide range of applications across multiple fields. Its unique chemical structure and properties make it an essential intermediate in synthetic chemistry, contributing to advancements in pharmaceuticals, agrochemicals, materials science, and more. Ongoing research continues to uncover new possibilities for this versatile compound, ensuring its relevance and importance in both academic and industrial settings.

• 26052-05-1(methyl(1H-pyrrol-2-ylmethyl)amine)
• 4608-34-8(n,n'-bis-2-pyridylmethyl ethylenediamine)
• 62402-28-2(1,2-Ethanediamine, N-(2-aminoethyl)-N'-(2-pyridinylmethyl)-)
• 1539-42-0(Bis(2-pyridylmethyl)amine)
• 6971-57-9(methyl[(6-methylpyridin-2-yl)methyl]amine)
• 43071-19-8(2-(Dimethylaminomethyl)-pyridine)
• 150099-69-7(N-(Pyridin-2-ylmethyl)prop-2-yn-1-amine)
• 499769-44-7(ethyl(6-methylpyridin-2-yl)methylamine)
• 16597-69-6(2-Pyridinemethanaminium, N,N,N-trimethyl-)
• 51639-58-8(N-Ethyl-N-(2-pyridylmethyl)amine)