• 1. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 2. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 5. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes

3-Bromo-5-T-butyl-2-fluorophenylboronic Acid: A Comprehensive Overview

The compound 3-Bromo-5-T-butyl-2-fluorophenylboronic acid, with the CAS number 2096333-35-4, is a highly specialized aromatic boronic acid derivative. This compound has garnered significant attention in the fields of organic synthesis, materials science, and drug discovery due to its unique structural features and versatile reactivity. The molecule consists of a phenyl ring substituted with bromine, fluorine, and a tert-butyl group, along with a boronic acid moiety. These substituents not only enhance the compound's stability but also make it an ideal precursor for various cross-coupling reactions.

Recent advancements in cross-coupling chemistry have underscored the importance of boronic acids like 3-Bromo-5-T-butyl-2-fluorophenylboronic acid in constructing complex molecular architectures. The presence of the boronic acid group enables this compound to participate in Suzuki-Miyaura coupling reactions, which are widely used in the synthesis of biaryl compounds. The bulky tert-butyl group at the 5-position of the phenyl ring provides steric protection, ensuring high regioselectivity during these reactions. This feature is particularly valuable in the synthesis of heterocyclic compounds and bioactive molecules.

In addition to its role in cross-coupling reactions, 3-Bromo-5-T-butyl-2-fluorophenylboronic acid has been explored as a building block in the development of advanced materials. Its ability to form stable covalent bonds with other organic moieties makes it a promising candidate for the synthesis of high-performance polymers and organic semiconductors. Recent studies have demonstrated its utility in creating self-healing polymers, where the boronic acid group plays a critical role in dynamic covalent bonding networks.

The synthesis of 3-Bromo-5-T-butyl-2-fluorophenylboronic acid involves a multi-step process that typically begins with bromination or fluorination of an aromatic precursor followed by boronate ester formation and subsequent hydrolysis to yield the final product. The choice of reagents and reaction conditions is crucial to ensure high yields and purity. For instance, the use of palladium catalysts in certain steps has been shown to significantly improve reaction efficiency, as highlighted in recent publications on catalytic methods for boronic acid synthesis.

The application of 3-Bromo-5-T-butyl-2-fluorophenylboronic acid extends into medicinal chemistry, where it serves as an intermediate in the synthesis of potential drug candidates. Its ability to undergo various transformations while retaining key functional groups makes it an invaluable tool for medicinal chemists. For example, recent research has focused on its use in developing inhibitors for kinase enzymes, which are implicated in various disease states such as cancer and inflammatory disorders.

In conclusion, 3-Bromo-5-T-butyl-2-fluorophenylboronic acid is a versatile compound with a wide range of applications across multiple disciplines. Its unique structure and reactivity make it an essential building block in modern organic synthesis. As research continues to uncover new methods for its preparation and utilization, this compound is poised to play an even greater role in advancing scientific discoveries and technological innovations.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)