Cas no 20949-84-2 (2-methyl-1,3-thiazole-4-carbaldehyde)

2-Methyl-1,3-thiazole-4-carbaldehyde is a heterocyclic aldehyde featuring a thiazole core with a formyl group at the 4-position and a methyl substituent at the 2-position. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its reactive aldehyde group enables condensation, reduction, and nucleophilic addition reactions, facilitating the construction of complex molecular frameworks. The thiazole moiety contributes to its utility in medicinal chemistry, often enhancing biological activity. The compound is characterized by its stability under standard conditions and compatibility with a range of synthetic methodologies, making it a valuable building block for research and industrial applications.
2-methyl-1,3-thiazole-4-carbaldehyde structure
20949-84-2 structure
Product Name:2-methyl-1,3-thiazole-4-carbaldehyde
CAS No:20949-84-2
MF:C5H5NOS
MW:127.164299726486
MDL:MFCD06655197
CID:95323
PubChem ID:2763191
Update Time:2025-11-02

2-methyl-1,3-thiazole-4-carbaldehyde Chemical and Physical Properties

Names and Identifiers

    • 4-Formyl-2-methylthiazole
    • IFLAB-BB F2124-0689
    • 4-THIAZOLECARBOXALDEHYDE, 2-METHYL-
    • 2-METHYL-1,3-THIAZOLE-4-CARBALDEHYDE
    • 2-Methyl-1,3-thiazole-4-carboxaldehyde
    • 4-Formyl-2-methyl-1,3-thiazole
    • 2-Methyl-4-thiazolecarboxaldehyde
    • 2-Methylthiazole-4-carboxaldehyde
    • 2-Methylthiazole-4-carbaldehyde
    • 2-Methylthiazole 4-carbaldehyde
    • 2-methyl-4-formylthiazole
    • PubChem15112
    • 2-methyl-4-formyl-thiazole
    • 2-methythiazole-4-carboxaldehyde
    • 2-methyl-thiazole-4-carbaldehyde
    • AEHWVNPVEUVPMT-UHFFFAOYSA-N
    • 4-Thiazolecarboxal
    • AM20090176
    • 20949-84-2
    • PS-5360
    • 4-Thiazolecarboxaldehyde,2-methyl-
    • AKOS000118579
    • CS-W003295
    • FT-0647824
    • SCHEMBL1107430
    • 2-Methylthiazole-4-carboxaldehyde, 97%
    • AB25415
    • SY033287
    • W-206579
    • Z90662164
    • DTXSID70376800
    • A4552
    • EN300-10920
    • MFCD06655197
    • DB-011353
    • 2-methyl-1,3-thiazole-4-carbaldehyde
    • MDL: MFCD06655197
    • Inchi: 1S/C5H5NOS/c1-4-6-5(2-7)3-8-4/h2-3H,1H3
    • InChI Key: AEHWVNPVEUVPMT-UHFFFAOYSA-N
    • SMILES: S1C=C(C=O)N=C1C

Computed Properties

  • Exact Mass: 127.00900
  • Monoisotopic Mass: 127.009
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 8
  • Rotatable Bond Count: 1
  • Complexity: 96.4
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 58.2
  • XLogP3: 1.1

Experimental Properties

  • Density: 1.27
  • Melting Point: 54-58?°C
  • Boiling Point: 219°C at 760 mmHg
  • Flash Point: Degrees Fahrenheit:>230°F
    Degrees Celsius:>110°C
  • Refractive Index: 1.601
  • PSA: 58.20000
  • LogP: 1.26400

2-methyl-1,3-thiazole-4-carbaldehyde Security Information

  • Symbol: GHS07
  • Signal Word:Warning
  • Hazard Statement: H302
  • Warning Statement: P261-P305+P351+P338
  • Hazardous Material transportation number:NONH for all modes of transport
  • WGK Germany:3
  • Hazard Category Code: 22
  • Hazardous Material Identification: Xn
  • Storage Condition:Inert atmosphere,2-8°C
  • Risk Phrases:R22

2-methyl-1,3-thiazole-4-carbaldehyde Customs Data

  • HS CODE:2934100090
  • Customs Data:

    China Customs Code:

    2934100090

    Overview:

    2934100090. Compounds that structurally contain a non fused thiazole ring(Whether hydrogenated or not). VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

2-methyl-1,3-thiazole-4-carbaldehyde Pricemore >>

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Additional information on 2-methyl-1,3-thiazole-4-carbaldehyde

Comprehensive Overview of 2-Methyl-1,3-thiazole-4-carbaldehyde (CAS No. 20949-84-2)

2-Methyl-1,3-thiazole-4-carbaldehyde (CAS No. 20949-84-2) is a versatile organic compound widely used in pharmaceuticals, agrochemicals, and flavor/fragrance industries. Its unique thiazole ring structure and aldehyde functional group make it a valuable intermediate for synthesizing complex molecules. Researchers and manufacturers prioritize this compound due to its reactivity and compatibility with diverse chemical transformations.

The growing demand for heterocyclic compounds like 2-methyl-1,3-thiazole-4-carboxaldehyde (a common variant name) aligns with trends in drug discovery and sustainable chemistry. Recent studies highlight its role in developing antimicrobial agents and biodegradable materials, addressing global concerns about antibiotic resistance and environmental pollution. Users frequently search for "thiazole derivatives applications" or "CAS 20949-84-2 suppliers," reflecting commercial and academic interest.

From a synthetic perspective, 2-methyl-1,3-thiazole-4-carbaldehyde serves as a precursor for Schiff base ligands in catalysis and flavor enhancers in food technology. Its low molecular weight (141.18 g/mol) and moderate polarity facilitate purification and scalability. Analytical methods such as HPLC and GC-MS are commonly employed for quality control, ensuring compliance with industry standards like ISO and GMP.

Environmental and safety profiles of thiazole-4-carbaldehyde derivatives are frequently discussed in forums. While the compound isn’t classified as hazardous under GHS, proper handling protocols—including ventilation and PPE—are recommended. Searches for "green synthesis of thiazole aldehydes" indicate rising interest in eco-friendly production methods, such as microwave-assisted reactions or biocatalysis.

In the pharmaceutical sector, 20949-84-2 is investigated for structure-activity relationships (SAR) in kinase inhibitors and anti-inflammatory drugs. Patent databases reveal its inclusion in novel small-molecule therapeutics, particularly for metabolic disorders. This correlates with trending queries like "thiazole aldehyde medicinal uses" and "CAS 20949-84-2 price," underscoring its economic relevance.

Future research directions may explore 2-methyl-1,3-thiazole-4-carbaldehyde’s potential in material science, such as conductive polymers or sensors. Cross-disciplinary collaborations could unlock applications in optoelectronics or nanotechnology, aligning with searches for "advanced organic building blocks." As industries prioritize innovation, this compound’s adaptability ensures sustained scientific and commercial traction.

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