• 1. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 2. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 3. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 4. Achieving Efficient Uranium Extraction by In-situ Ultrasonic Texturization of Commercial Fe Powder
  BomingZhu,HongweiWu,JieKang,XiaofangYu,TaoChen,RuCheng,GuolinYang,WencaiBai,WenkunZhu,RongHe
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

5-Fluoro-7-Iodo-1H-lndazole: A Comprehensive Overview

The compound 5-fluoro-7-iodo-1H-indazole, identified by the CAS number 2090315-40-3, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the indazole family, which is a heterocyclic aromatic system with two nitrogen atoms in the ring. The presence of fluorine and iodine substituents at specific positions on the indazole ring imparts unique electronic and structural properties to this molecule, making it a valuable tool in various research and industrial applications.

Recent studies have highlighted the potential of 5-fluoro-7-iodo-1H-indazole as a precursor in the synthesis of bioactive compounds. Its ability to undergo various nucleophilic aromatic substitutions and cross-coupling reactions has made it a versatile building block in medicinal chemistry. For instance, researchers have utilized this compound to develop novel anti-cancer agents with enhanced selectivity and efficacy. The fluorine substituent at position 5 plays a critical role in modulating the electronic properties of the molecule, while the iodine atom at position 7 serves as an excellent leaving group, facilitating further functionalization.

In addition to its role in drug discovery, 5-fluoro-7-iodo-1H-indazole has also been explored for its applications in materials science. The indazole core is known for its high thermal stability and strong electron-withdrawing properties, which make it suitable for use in organic semiconductors and optoelectronic devices. Recent advancements in this area have demonstrated that derivatives of this compound can exhibit desirable charge transport properties, paving the way for their integration into next-generation electronic materials.

The synthesis of 5-fluoro-7-iodo-1H-indazole typically involves multi-step processes that require precise control over reaction conditions. One common approach involves the substitution of an iodine atom onto an indazole derivative followed by fluorination at the appropriate position. Researchers have optimized these steps to achieve high yields and purity levels, ensuring that the compound meets the stringent requirements of modern pharmaceutical and materials research.

From a structural standpoint, 5-fluoro-7-ioto-iindazole exhibits a planar geometry due to the aromaticity of the indazole ring. The electronegative substituents at positions 5 and 7 introduce significant electron-withdrawing effects, which influence both its chemical reactivity and physical properties. These characteristics make it an ideal candidate for exploring novel chemical transformations and for designing molecules with tailored functionalities.

In conclusion, 5-fluoro-iiodo-iindazole stands out as a versatile and valuable compound with diverse applications across multiple disciplines. Its unique combination of electronic properties and structural features positions it as a key player in contemporary research efforts aimed at developing innovative solutions in medicine, materials science, and beyond.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)