Cas no 2089320-98-7 (tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate)
Tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate is a chiral piperidine derivative featuring a tert-butoxycarbonyl (Boc) protecting group and difluorination at the 5-position. This compound serves as a valuable intermediate in organic synthesis, particularly in pharmaceutical research, where its stereochemistry and fluorine substitution enhance bioactivity and metabolic stability. The Boc group facilitates selective deprotection under mild acidic conditions, enabling further functionalization. Its rigid, fluorinated structure contributes to improved binding affinity and lipophilicity in drug design. The (3R) configuration ensures enantioselective applications, making it useful for the development of targeted therapeutics. Suitable for peptide coupling and medicinal chemistry applications, it offers precise control in complex synthetic routes.
![tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate structure](https://ossimg.kuujia.com/scimg/2089500/2089320-98-7x500.png)
2089320-98-7 structure
Product Name:tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate
CAS No:2089320-98-7
MF:C10H18F2N2O2
MW:236.2589
MDL:MFCD31742664
CID:5095867
PubChem ID:97291627
Update Time:2026-03-02
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate Chemical and Physical Properties
Names and Identifiers
-
- tert-butyl (R)-(5,5-difluoropiperidin-3-yl)carbamate
- (R)-tert-butyl 5,5-difluoropiperidin-3-ylcarbamate
- tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate
- Carbamic acid, N-?[(3R)?-?5,?5-?difluoro-?3-?piperidinyl]?-?, 1,?1-?dimethylethyl ester
- (3R)-3-(Boc-amino)-5,5-difluoropiperidine
- D75190
- t-Butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate
- EN300-1692278
- SCHEMBL23068132
- 2089320-98-7
- AS-84832
- MFCD31742664
- CS-0091702
- (R)-3-(Boc-amino)-5,5-difluoropiperidine
-
- MDL： MFCD31742664
- Inchi： 1S/C10H18F2N2O2/c1-9(2,3)16-8(15)14-7-4-10(11,12)6-13-5-7/h7,13H,4-6H2,1-3H3,(H,14,15)/t7-/m1/s1
- InChI Key： NZEASWFMIYVAAZ-SSDOTTSWSA-N
- SMILES： FC1(C([H])([H])N([H])C([H])([H])[C@@]([H])(C1([H])[H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])F
Computed Properties
- Exact Mass: 236.13363415g/mol
- Monoisotopic Mass: 236.13363415g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 16
- Rotatable Bond Count: 3
- Complexity: 264
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.4
- Topological Polar Surface Area: 50.4
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| eNovation Chemicals LLC | Y1006174-100mg |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 100mg |
$250 | 2024-05-23 | |
| eNovation Chemicals LLC | Y1006174-250MG |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 250mg |
$385 | 2024-05-23 | |
| eNovation Chemicals LLC | Y1006174-500MG |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 500mg |
$645 | 2024-05-23 | |
| eNovation Chemicals LLC | Y1006174-1G |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 1g |
$965 | 2024-05-23 | |
| eNovation Chemicals LLC | Y1006174-5G |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 5g |
$2905 | 2024-05-23 | |
| eNovation Chemicals LLC | Y1006174-10G |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 10g |
$4940 | 2024-05-23 | |
| Enamine | EN300-1692278-1g |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 95% | 1g |
$2745.0 | 2023-09-20 | |
| Enamine | EN300-1692278-5g |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 95% | 5g |
$7961.0 | 2023-09-20 | |
| Enamine | EN300-1692278-10g |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 95% | 10g |
$11805.0 | 2023-09-20 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB93576-100MG |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate |
2089320-98-7 | 97% | 100MG |
￥ 1,287.00 | 2023-04-03 |
tert-butyl N-[(3R)-5,5-difluoropiperidin-3-yl]carbamate Related Literature
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Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
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Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
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J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
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Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
-
Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
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