• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 3. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 4. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Comprehensive Overview of 4-(Piperidin-4-ylamino)benzonitrile (CAS No. 208398-34-9): Properties, Applications, and Research Insights

4-(Piperidin-4-ylamino)benzonitrile (CAS No. 208398-34-9) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features and potential applications. This piperidine derivative combines a benzonitrile moiety with a piperidin-4-ylamino group, making it a valuable intermediate in drug discovery and material science. Its molecular formula, C₁₂H₁₅N₃, and molecular weight of 201.27 g/mol reflect its compact yet functionally rich architecture.

In recent years, the demand for nitrile-containing compounds like 4-(Piperidin-4-ylamino)benzonitrile has surged, driven by their versatility in synthesizing heterocyclic pharmaceuticals. Researchers frequently explore its role in modulating kinase inhibitors and G-protein-coupled receptor (GPCR) targets, aligning with trends in precision medicine. The compound’s hydrogen-bonding capacity and lipophilic efficiency make it a candidate for optimizing drug bioavailability, a hot topic in ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies.

Synthetic routes to CAS 208398-34-9 often involve nucleophilic aromatic substitution or reductive amination strategies, with yields optimized through microwave-assisted synthesis—a technique gaining traction for its eco-friendly and time-efficient profile. Analytical characterization typically employs HPLC, NMR spectroscopy, and mass spectrometry, ensuring high purity for research applications. Notably, its melting point (reported ~150–155°C) and solubility profile (moderate in polar solvents like DMSO) are critical for formulation scientists.

Beyond pharmaceuticals, 4-(Piperidin-4-ylamino)benzonitrile intersects with agrochemical innovation, where its scaffold contributes to designing novel pest control agents. This dual applicability resonates with the growing emphasis on sustainable chemistry and green synthesis, topics dominating academic and industrial discourse. Patent literature reveals its utility in crop protection formulations, addressing global food security challenges—a key concern in 2024.

From a commercial perspective, suppliers of CAS 208398-34-9 highlight its use in high-throughput screening libraries, catering to AI-driven drug discovery platforms. The compound’s structure-activity relationship (SAR) data is often leveraged in machine learning models to predict bioactivity, a synergy between wet-lab and computational chemistry that’s revolutionizing R&D. FAQs from researchers frequently inquire about its stability under physiological conditions and compatibility with click chemistry protocols.

Regulatory compliance for 208398-34-9 adheres to REACH and FDA guidelines, with no current restrictions, facilitating its global trade. Storage recommendations emphasize protection from moisture and light, with standard room temperature conditions. Safety data sheets (SDS) classify it as non-hazardous under normal handling, though standard PPE (personal protective equipment) is advised—a detail often queried by laboratory personnel.

In conclusion, 4-(Piperidin-4-ylamino)benzonitrile exemplifies the intersection of medicinal chemistry and industrial innovation. Its adaptability across therapeutic and agricultural domains, coupled with advancements in computational drug design, positions it as a compound of enduring relevance. Future research may explore its catalytic applications or polymeric material integrations, further expanding its scientific footprint.

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