• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
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• 2. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
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• 3. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
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• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
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• 5. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761

Comprehensive Overview of (5-bromo-[1,1'-biphenyl]-3-yl)boronic acid (CAS No. 2081938-84-1)

(5-bromo-[1,1'-biphenyl]-3-yl)boronic acid (CAS No. 2081938-84-1) is a highly versatile boronic acid derivative widely utilized in organic synthesis, pharmaceutical research, and material science. This compound belongs to the class of arylboronic acids, which are pivotal intermediates in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern drug discovery and agrochemical development. Its unique structure, featuring a bromine substituent and a boronic acid group, enables selective functionalization, making it invaluable for constructing complex biaryl scaffolds.

The growing demand for high-purity boronic acids in catalysis and medicinal chemistry has placed compounds like (5-bromo-[1,1'-biphenyl]-3-yl)boronic acid at the forefront of research. Recent trends highlight its role in developing targeted therapies, particularly in oncology and neurodegenerative disease research, where precision in molecular design is critical. Analysts note a surge in searches for "boronic acid applications in drug delivery" and "Suzuki coupling reagents 2024," reflecting industry interest.

From a synthetic perspective, CAS 2081938-84-1 exhibits excellent stability under standard conditions, though storage recommendations emphasize protection from moisture to preserve its reactivity. Its melting point, solubility profile, and NMR spectral data are well-documented, aiding researchers in quality control. The compound’s biphenyl core also contributes to OLED material research, aligning with the booming demand for organic electronics.

Environmental and regulatory considerations for (5-bromo-[1,1'-biphenyl]-3-yl)boronic acid adhere to standard laboratory safety protocols. While not classified as hazardous under major chemical inventories, proper handling with PPE is advised due to its potential irritant properties. This aligns with increasing Google queries about "safe handling of boronic acids" and "green chemistry alternatives," underscoring the need for balanced scientific and safety discourse.

In the pharmaceutical sector, this compound’s structure-activity relationship (SAR) studies have enabled breakthroughs in kinase inhibitor design. Patent analyses reveal its incorporation into preclinical candidates targeting inflammatory pathways, with researchers frequently searching for "boronic acid protease inhibitors" and "biphenyl medicinal chemistry." Its meta-substituted boronic acid configuration offers distinct steric advantages in binding interactions.

The commercial availability of CAS 2081938-84-1 through major chemical suppliers ensures accessibility for global R&D teams. Pricing trends correlate with scale-up challenges in boron-containing compound synthesis, a topic gaining traction in "cost-effective boronic acid production" discussions. Analytical techniques like HPLC and mass spectrometry are routinely employed to verify its ≥95% purity, a key specification for catalytic applications.

Future prospects for (5-bromo-[1,1'-biphenyl]-3-yl)boronic acid include emerging roles in bioconjugation and diagnostic probe development, particularly in PET imaging ligand synthesis. This aligns with PubMed’s rising citations on "boronic acid sensors" and "theranostic agents." As the fine chemicals market expands, this compound’s structural modularity positions it as a sustainable choice for next-generation therapeutics.

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