• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives Thiophene carboxylic acids

Comprehensive Overview of 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid (CAS No. 208108-76-3)

4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid (CAS No. 208108-76-3) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. This compound belongs to the thiophene carboxylic acid family, characterized by a phenyl group at the 4-position and a trifluoromethyl group at the 5-position of the thiophene ring. Its molecular formula is C₁₂H₇F₃O₂S, and it exhibits a molecular weight of 272.24 g/mol. The presence of the trifluoromethyl moiety enhances its lipophilicity, making it a valuable intermediate in drug discovery and material science.

The compound's CAS No. 208108-76-3 is frequently searched in academic and industrial databases, reflecting its relevance in modern synthetic chemistry. Researchers are particularly interested in its potential applications as a building block for heterocyclic compounds, which are pivotal in designing bioactive molecules. Recent studies highlight its utility in developing antimicrobial agents and anti-inflammatory drugs, aligning with the growing demand for novel therapeutics. Additionally, its thiophene core structure is a hotspot for organic electronics, such as OLEDs and conductive polymers, addressing the surge in sustainable material innovations.

One of the most searched questions related to 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid revolves around its synthesis methods. The compound is typically synthesized via palladium-catalyzed cross-coupling reactions or multicomponent reactions, which are efficient and scalable. Another trending topic is its solubility and stability under various conditions, critical for formulation scientists. The trifluoromethyl group also sparks curiosity due to its role in improving metabolic stability, a key factor in drug design.

From an SEO perspective, keywords like "thiophene derivatives", "trifluoromethyl compounds", and "carboxylic acid applications" are highly relevant. These terms align with user queries on platforms like Google Scholar and PubChem, where professionals seek data on structure-activity relationships (SAR) and patent literature. The compound's versatility also ties into broader discussions on green chemistry, as researchers explore eco-friendly synthesis routes to minimize waste.

In summary, 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid (CAS No. 208108-76-3) is a multifaceted compound with expanding applications in pharmaceuticals, agrochemicals, and advanced materials. Its unique structural features and functional groups make it a subject of ongoing research, particularly in addressing global challenges like drug resistance and sustainable technology. As interest grows, so does the need for detailed technical data, positioning this compound as a cornerstone in modern chemical innovation.

• 167279-18-7(Ethyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate)
• 237385-98-7(Methyl 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylate)
• 861960-58-9(2-Thiophenecarboxylic acid,4-cyano-3-[4-(1,1-dimethylethyl)phenyl]-5-(trifluoromethyl)-)
• 128009-32-5(5-(Trifluoromethyl)thiophene-2-carboxylic acid)
• 874832-11-8(4-Phenyl-5-(trifluoromethyl)thiophene-2-carbaldehyde)
• 849066-52-0(3-Amino-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylic Acid)
• 208108-54-7(2-Thiophenecarboxylicacid, 4-(4-chlorophenyl)-5-(trifluoromethyl)-, ethyl ester)
• 256488-46-7((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methanol)
• 190723-10-5(2-Thiophenecarboxylic acid, 3-methyl-5-(trifluoromethyl)-, methyl ester)
• 767337-59-7(3-(Trifluoromethyl)thiophene-2-carboxylic acid)