Cas no 207853-66-5 (2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride)

2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride is a highly reactive sulfonyl chloride derivative, primarily employed as a key intermediate in organic synthesis. Its distinct structure, featuring bromine and fluorine substituents, enhances its utility in cross-coupling reactions and nucleophilic substitutions, enabling precise functionalization of target molecules. The electron-withdrawing effects of the halogens improve electrophilic reactivity, making it valuable for constructing complex sulfonamide-based compounds. This compound is particularly useful in pharmaceutical and agrochemical research, where selective sulfonylation is required. Its stability under controlled conditions ensures consistent performance in synthetic applications. Proper handling is essential due to its moisture sensitivity and potential reactivity with nucleophiles.
2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride structure
207853-66-5 structure
Product Name:2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride
CAS No:207853-66-5
MF:C6HBr2ClF2O2S
MW:370.393745183945
MDL:MFCD00052364
CID:92375
PubChem ID:574297
Update Time:2025-11-02

2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride Chemical and Physical Properties

Names and Identifiers

    • 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride
    • AC1LCCIH
    • AC1Q4N40
    • ACMC-20aobg
    • AG-E-52592
    • AR-1D4173
    • CTK4E5115
    • CS-0333649
    • AKOS000143745
    • 207853-66-5
    • SCHEMBL1022230
    • 2,5-Dibromo-3,6-difluorobenzenesulphonyl chloride
    • DTXSID50341596
    • 2,5-dibromo-3,6-difluorobenzene-1-sulfonyl chloride
    • MFCD00052364
    • 2,5-dibromo-3,6-difluorobenzene-1-sulfonylchloride
    • 2,5-dibromo-3,6-difluoro-benzenesulfonyl chloride
    • MDL: MFCD00052364
    • Inchi: 1S/C6HBr2ClF2O2S/c7-2-1-3(10)4(8)6(5(2)11)14(9,12)13/h1H
    • InChI Key: OTBDNAGWXGDPNX-UHFFFAOYSA-N
    • SMILES: BrC1C(=CC(=C(C=1S(=O)(=O)Cl)F)Br)F

Computed Properties

  • Exact Mass: 367.77200
  • Monoisotopic Mass: 367.772
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 1
  • Complexity: 307
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 3.5
  • Topological Polar Surface Area: 42.5A^2

Experimental Properties

  • Color/Form: Beige powder
  • Density: 2.219
  • Melting Point: 68-73 °C
  • Boiling Point: 331.3°C at 760 mmHg
  • Flash Point: 154.1°C
  • Refractive Index: 1.586
  • PSA: 42.52000
  • LogP: 4.49810
  • Sensitiveness: Moisture Sensitive
  • Solubility: React with water

2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride Security Information

  • Hazardous Material transportation number:UN 1759
  • Hazard Category Code: 34-25
  • Safety Instruction: S26-S36/37/39-S45
  • Hazardous Material Identification: C
  • HazardClass:8
  • PackingGroup:II
  • Safety Term:S26;S36/37/39;S45
  • Packing Group:II
  • Risk Phrases:R34
  • Packing Group:II

2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride Customs Data

  • HS CODE:2904909090
  • Customs Data:

    China Customs Code:

    2904909090

    Overview:

    2904909090 Sulfonation of other hydrocarbons\nitrification\Nitrosative derivative(Whether halogenated or not). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride Pricemore >>

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Additional information on 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride

Comprehensive Overview of 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride (CAS No. 207853-66-5)

2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride (CAS No. 207853-66-5) is a highly specialized aromatic sulfonyl chloride derivative, widely recognized for its unique chemical properties and applications in advanced organic synthesis. This compound belongs to the class of halogenated benzenesulfonyl chlorides, which are pivotal intermediates in the pharmaceutical, agrochemical, and material science industries. Its molecular structure, featuring bromine and fluorine substituents, imparts exceptional reactivity, making it a valuable building block for constructing complex molecules.

In recent years, the demand for 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride has surged due to its role in the development of high-performance polymers and electronic materials. Researchers and manufacturers are increasingly exploring its potential in creating fluorinated polymers, which exhibit superior thermal stability, chemical resistance, and dielectric properties. These characteristics are critical for applications in semiconductor manufacturing, flexible electronics, and renewable energy technologies, aligning with global trends toward sustainability and innovation.

The synthesis of 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride involves multi-step halogenation and sulfonation processes, ensuring high purity and yield. Its CAS No. 207853-66-5 serves as a unique identifier in chemical databases, facilitating seamless procurement and regulatory compliance. The compound's stability under controlled conditions and compatibility with various solvents further enhance its utility in laboratory-scale and industrial-scale applications.

One of the most frequently searched questions related to this compound is: "What are the applications of 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride in material science?" The answer lies in its ability to act as a precursor for sulfonamide derivatives, which are integral to designing ion-exchange membranes and proton-conducting materials. These materials are essential for fuel cells and battery technologies, addressing the growing need for clean energy solutions.

Another trending topic is the compound's role in pharmaceutical intermediates. With the rise of targeted drug delivery systems and bioconjugation techniques, 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride is gaining attention for its potential in modifying biomolecules and enhancing drug efficacy. Its reactivity with amines and alcohols enables the creation of customized drug candidates, meeting the demands of modern precision medicine.

From an environmental perspective, the compound's halogenated structure raises questions about its ecological impact and handling protocols. Industry best practices emphasize proper storage, waste management, and adherence to green chemistry principles to minimize environmental footprint. Innovations in catalytic processes and solvent recovery systems are further reducing the ecological concerns associated with its production.

In summary, 2,5-Dibromo-3,6-difluorobenzenesulfonyl chloride (CAS No. 207853-66-5) stands at the intersection of chemistry, technology, and sustainability. Its versatility in organic synthesis, coupled with its relevance to cutting-edge industries, ensures its continued prominence in scientific and industrial discourse. As research advances, this compound is poised to play an even greater role in shaping the future of advanced materials and life sciences.

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