• 1. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 2. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 3. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416
• 4. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

Comprehensive Overview of Methyl 5-methyl-3-phenyl-4-isoxazolecarboxylate (CAS No. 2065-28-3): Properties, Applications, and Industry Insights

Methyl 5-methyl-3-phenyl-4-isoxazolecarboxylate (CAS No. 2065-28-3) is a specialized organic compound belonging to the isoxazole family, a heterocyclic scaffold widely recognized for its versatility in pharmaceutical and agrochemical applications. This ester derivative, characterized by its methyl carboxylate and phenyl substituents, has garnered significant attention in synthetic chemistry due to its role as a key intermediate in the development of bioactive molecules. Its molecular structure, combining aromatic and heterocyclic motifs, offers unique reactivity patterns that align with modern green chemistry and sustainable synthesis trends—topics highly searched in AI-driven research platforms.

In recent years, the demand for Methyl 5-methyl-3-phenyl-4-isoxazolecarboxylate has surged, driven by its utility in drug discovery and material science. Researchers frequently query its synthetic routes, spectroscopic data (e.g., NMR, IR), and solubility profiles—common long-tail keywords in scientific databases. The compound’s lipophilicity and hydrogen-bonding capacity make it a candidate for optimizing bioavailability in medicinal chemistry, a hot topic in AI-assisted drug design. Notably, its stability under mild conditions aligns with industry shifts toward energy-efficient processes, another trending search term.

From an industrial perspective, CAS 2065-28-3 is often discussed in forums focusing on high-value intermediates and scalable synthesis. Its compatibility with catalytic reactions (e.g., Pd-catalyzed cross-coupling) addresses the growing interest in atom-economical transformations. Environmental concerns have also propelled searches for its biodegradability and eco-friendly derivatives, reflecting broader societal priorities. Analytical techniques like HPLC purity analysis and crystallography studies are frequently associated with this compound, underscoring its rigorous quality control requirements.

Innovative applications of Methyl 5-methyl-3-phenyl-4-isoxazolecarboxylate extend to electronic materials, where its conjugated system is explored for organic semiconductors. This intersects with the booming interest in flexible electronics and IoT devices—topics dominating tech-related searches. Furthermore, its potential in crop protection formulations resonates with agrochemical researchers investigating low-toxicity pesticides, a critical area amid global food security debates.

Regulatory and safety profiles of CAS 2065-28-3 are meticulously documented, complying with REACH and GMP standards—frequently searched compliance terms. The compound’s storage stability and handling protocols are detailed in technical datasheets, addressing common user queries about long-term degradation and inert atmosphere storage. Such precision ensures its adoption in GMP-certified facilities, a priority for pharmaceutical manufacturers.

In summary, Methyl 5-methyl-3-phenyl-4-isoxazolecarboxylate exemplifies the convergence of cutting-edge research and industrial practicality. Its multifaceted role—from small-molecule APIs to advanced materials—positions it as a compound of enduring relevance, mirroring the interdisciplinary queries seen in modern search engines and AI-driven literature mining tools.

• 1143-82-4(Ethyl 5-methyl-3-phenylisoxazole-4-carboxylate)
• 91569-58-3(5-methyl-3-(o-tolyl)isoxazole-4-carboxylic acid)
• 96426-11-8(4-Isoxazolecarboxylic acid, 5-methyl-3-phenyl-, 1-methylethyl ester)
• 55278-58-5(4-Isoxazolecarboxylicacid,3-[1,1-biphenyl]-4-yl-5-methyl-,methylester(9CI))
• 68870-58-6(Methyl 3-(4-chlorophenyl)-5-methylisoxazole-4-carboxylate)
• 848186-84-5(4-Isoxazolecarboxylicacid, 3-[1,1'-biphenyl]-2-yl-5-methyl-, ethyl ester)
• 1136-45-4(5-Methyl-3-phenyl-4-isoxazolecarboxylic Acid)
• 823218-96-8(4-Isoxazolecarboxylic acid, 5-methyl-3-(2,4,6-trimethylphenyl)-, methylester)
• 91569-59-4(5-Methyl-3-(4-methylphenyl)isoxazole-4-carboxylic acid)
• 30118-89-9(4-Isoxazolecarboxylicacid, 5-[(acetyloxy)methyl]-3-phenyl-)