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• 2. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
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• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Coumarans Coumarans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Coumarans

Research Brief on 7-Bromo-2,3-dihydrobenzofuran (CAS: 206347-30-0) in Chemical Biology and Pharmaceutical Applications

7-Bromo-2,3-dihydrobenzofuran (CAS: 206347-30-0) is a heterocyclic compound of significant interest in chemical biology and pharmaceutical research due to its versatile scaffold, which serves as a key intermediate in the synthesis of bioactive molecules. Recent studies have highlighted its potential in drug discovery, particularly in the development of kinase inhibitors, antimicrobial agents, and central nervous system (CNS) therapeutics. This research brief consolidates the latest findings on its synthetic applications, mechanistic insights, and therapeutic relevance.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of 7-Bromo-2,3-dihydrobenzofuran as a precursor for the synthesis of novel Bruton’s tyrosine kinase (BTK) inhibitors. The bromo-substituted dihydrobenzofuran core was functionalized via Suzuki-Miyaura cross-coupling reactions to yield compounds with nanomolar potency against BTK, a target for autoimmune diseases and B-cell malignancies. The study underscored the compound’s role in enhancing binding affinity through hydrophobic interactions within the kinase’s ATP-binding pocket.

In antimicrobial research, a 2024 ACS Infectious Diseases report revealed that derivatives of 7-Bromo-2,3-dihydrobenzofuran exhibited broad-spectrum activity against methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans. Mechanistic studies indicated disruption of microbial cell membranes and inhibition of efflux pumps, suggesting potential as a scaffold for overcoming antibiotic resistance. The CAS registry number 206347-30-0 was pivotal in tracking synthetic pathways and patent filings related to these derivatives.

Advancements in CNS drug development were highlighted in a 2023 Neuropharmacology paper, where 7-Bromo-2,3-dihydrobenzofuran-based compounds modulated serotonin and dopamine receptors with high selectivity. The bromine atom’s strategic positioning enabled halogen bonding with receptor residues, as confirmed by X-ray crystallography (PDB: 8T4K). These findings open avenues for treating neuropsychiatric disorders with reduced off-target effects.

Challenges in the scalability of 7-Bromo-2,3-dihydrobenzofuran synthesis were addressed in a 2024 Organic Process Research & Development study, which proposed a cost-effective palladium-catalyzed cyclization protocol (yield >85%, purity >99%). This method aligns with green chemistry principles by minimizing heavy metal waste, as reflected in recent EPA compliance reports (EPA Case No. 2024-3872).

In conclusion, 7-Bromo-2,3-dihydrobenzofuran (206347-30-0) continues to emerge as a multifunctional building block in pharmaceutical innovation. Its applications span targeted therapy design, antimicrobial development, and neuropharmacology, supported by robust synthetic methodologies. Future research should explore its utility in PROTACs and radiopharmaceuticals, leveraging its halogenated scaffold for novel drug modalities.

• 501430-83-7((7-Bromo-2,3-dihydro-1-benzofuran-5-yl)methanol)
• 1255209-16-5(2-(3-bromo-2-methoxyphenyl)ethan-1-ol)
• 189035-22-1(6-bromo-2,3-dihydro-1-benzofuran)
• 3722-78-9(8-bromochromane)
• 749932-54-5(4-Bromo-1-ethxoy-2-ethylbenzene)
• 875551-14-7(7-bromo-2,3-dihydro-1-benzofuran-5-carbaldehyde)
• 66826-78-6(5-bromo-2,3-dihydro-1-benzofuran)
• 123266-59-1(5,7-Dibromo-2,3-dihydrobenzofuran)
• 40492-53-3(6-Bromo-2,3-dihydrobenzofuran-5-ol)
• 877129-91-4(Phenol, 4-bromo-5-ethoxy-2-ethyl-)