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  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 2. An apparatus for determining small amounts of alchohol in sour milk and urine
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• 3. An automated in-chip-catalytic–spectrophotometric method for determination of copper(ii) using a multisyringe flow injection analysis-multipumping flow system?
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• 4. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
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• 5. Acetyl protected thiol methacrylic polymers as effective ligands to keep quantum dots in luminescent standby mode?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylazides

Introduction to (2-azidophenyl)methanol (CAS No. 20615-76-3)

Compound (2-azidophenyl)methanol (CAS No. 20615-76-3) is a specialized organic molecule that has garnered significant attention in the field of chemical and pharmaceutical research. This compound, characterized by its unique structural features, serves as a valuable intermediate in the synthesis of various pharmacologically active agents. The presence of both an azide functional group and a hydroxymethyl moiety makes it a versatile building block for medicinal chemists seeking to develop novel therapeutic entities.

The structure of (2-azidophenyl)methanol consists of a benzene ring substituted with an azide group at the 2-position and a methanol group at the 3-position. This particular arrangement imparts distinct chemical properties that are exploited in synthetic chemistry. The azide group, while known for its reactivity, also offers opportunities for further functionalization through various chemical transformations such as reduction to an amine or substitution with other functional groups. The hydroxymethyl group, on the other hand, provides a site for esterification or etherification, enabling the creation of more complex molecular architectures.

In recent years, there has been growing interest in the development of new drugs targeting central nervous system disorders. The pharmacological potential of (2-azidophenyl)methanol has been explored in several preclinical studies, where it has shown promise as a precursor for compounds with neuroprotective and anti-inflammatory properties. Researchers have leveraged its structural motifs to design molecules that interact with specific neurotransmitter receptors or enzymes involved in neurodegenerative processes.

One notable application of (2-azidophenyl)methanol is in the synthesis of small-molecule inhibitors targeting enzymes such as cyclooxygenase-2 (COX-2). These enzymes are implicated in pain and inflammation, making them attractive targets for drug development. By incorporating the (2-azidophenyl)methanol scaffold into potential drug candidates, scientists have been able to generate compounds with enhanced binding affinity and selectivity. This approach has led to the discovery of several lead compounds that are currently undergoing further optimization in clinical trials.

The role of (2-azidophenyl)methanol in medicinal chemistry extends beyond its use as an intermediate. Its unique reactivity allows for the exploration of novel synthetic pathways that may lead to more efficient and sustainable methods for drug production. For instance, recent studies have demonstrated its utility in cross-coupling reactions, where it serves as a precursor for arylated compounds with diverse biological activities. These reactions often involve palladium-catalyzed transformations, which are widely used in the pharmaceutical industry due to their high efficiency and mild reaction conditions.

The CAS No. 20615-76-3 identifier ensures that researchers can reliably obtain this compound from reputable suppliers while maintaining consistency in their experiments. This standardization is crucial for reproducibility in scientific research and for ensuring compliance with regulatory requirements. As part of good laboratory practices, proper handling and storage of (2-azidophenyl)methanol are essential to prevent degradation and maintain its integrity.

In conclusion, (2-azidophenyl)methanol represents a significant asset in the arsenal of synthetic organic chemistry and pharmaceutical research. Its unique structural features and reactivity make it an invaluable intermediate for developing novel therapeutic agents targeting various diseases. As research continues to uncover new applications and synthetic methodologies, the importance of this compound is likely to grow further, solidifying its role as a cornerstone in modern drug discovery efforts.

• 113302-83-3(Benzenemethanol, 2-azido-5-methyl-)
• 646054-88-8(Benzene, 2,4-diazido-1,3,5-trimethyl-)
• 646054-87-7(Benzene, 1,3-diazido-2-methyl-)
• 26334-20-3(2-azido-1,3-dimethylbenzene)
• 147647-81-2(Benzene,1-azido-2,4,5-trimethyl-)
• 17277-79-1(Benzenemethanol,2-[2-(4-amino-3-methylphenyl)diazenyl]-)
• 31499-54-4((4-Azidophenyl)methanol)
• 31656-92-5(1-azido-2-methylbenzene)
• 14213-00-4(2-azido-1,3,5-trimethylbenzene)
• 31162-13-7(2-azidobenzoic Acid)