• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
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• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
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  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Bromobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Bromobenzenes

3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol (CAS 206055-91-6): A Versatile Chemical Building Block

3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol (CAS 206055-91-6) is an important heterocyclic compound that has gained significant attention in pharmaceutical and material science research. This brominated isoxazole derivative serves as a valuable chemical intermediate for various synthetic applications. The compound features both an isoxazole ring and a hydroxymethyl group, making it particularly useful for further functionalization in organic synthesis.

The molecular structure of 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol combines the unique properties of an aromatic bromo substituent with the isoxazole heterocycle, creating a scaffold that's highly sought after in medicinal chemistry. Researchers are particularly interested in this compound's potential as a pharmacophore in drug discovery, especially in the development of anti-inflammatory agents and CNS-targeted therapeutics, which are currently hot topics in pharmaceutical research.

Recent trends in chemical research show growing interest in isoxazole-containing compounds like 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol due to their diverse biological activities. The compound's bromophenyl moiety allows for various cross-coupling reactions, making it valuable for creating more complex molecular architectures. This aligns well with current industry demands for versatile building blocks in drug discovery programs.

In material science applications, 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol has shown promise as a precursor for functional polymers and advanced materials. The hydroxymethyl group provides an excellent handle for polymerization reactions or further derivatization. Researchers are exploring its use in creating photoactive materials and molecular sensors, areas that have seen significant growth in recent years.

The synthesis and applications of 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol are frequently discussed in scientific literature, particularly in contexts involving click chemistry and bioorthogonal reactions. These methodologies are currently revolutionizing drug discovery and bioconjugation techniques. The compound's stability and reactivity profile make it suitable for various catalyzed transformations that are central to modern synthetic strategies.

Quality control of 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol typically involves advanced analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure the compound meets the stringent purity requirements for research and development applications. The growing emphasis on green chemistry principles has also led to investigations into more sustainable production methods for this and similar heterocyclic building blocks.

From a commercial perspective, 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol has seen steady demand from pharmaceutical and chemical research institutions. The compound is typically supplied in research quantities with detailed certificates of analysis, and its market availability reflects the broader trends in specialty chemicals for drug discovery. Suppliers often highlight its potential in fragment-based drug design and combinatorial chemistry applications.

Storage and handling of 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol require standard laboratory precautions for organic compounds. The material is generally stable under recommended storage conditions, though proper chemical compatibility assessments should be performed when planning experiments. These considerations align with current best practices in laboratory safety and chemical management protocols.

Future research directions for 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol may include exploration of its biological activities, development of novel synthetic methodologies using this scaffold, and investigation of its potential in catalysis and material science applications. The compound's structural features make it particularly interesting for medicinal chemistry optimization programs targeting various disease areas.

In conclusion, 3-(4-Bromo-phenyl)-isoxazol-5-yl-methanol (CAS 206055-91-6) represents a valuable chemical intermediate with diverse applications across multiple scientific disciplines. Its unique combination of aromatic bromine and isoxazole functionality ensures continued interest from researchers in both academia and industry. As synthetic methodologies advance and new applications emerge, this compound is likely to maintain its importance in the specialty chemicals landscape.

• 53573-22-1(Isoxazole, 5-(4-bromophenyl)-3-phenyl-)
• 954240-06-3((3-M-Tolyl-isoxazol-5-yl)methanol)
• 885273-13-2((3-(2-Bromophenyl)isoxazol-5-yl)methanol)
• 53573-21-0(Isoxazole, 3-(4-bromophenyl)-5-phenyl-)
• 885273-70-1((3-(3,4-Dimethylphenyl)isoxazol-5-yl)methanol)
• 887574-50-7(3-(3-Bromophenyl)- isoxazol-5-yl-methanol)
• 1159979-39-1(2-(3-(4-Bromophenyl)isoxazol-5-yl)ethanol)
• 90924-12-2((3-Phenyl-5-isoxazolyl)methanol)
• 885273-56-3((3-(o-Tolyl)isoxazol-5-yl)methanol)
• 885273-66-5(3-(4-Aminophenyl)-1,2-oxazol-5-ylmethanol)