• 1. Annulation of pyridine as a route to quinolines, isoquinolines, and cycloheptapyridines
  Gurnos Jones,R. K. Jones J. Chem. Soc. Perkin Trans. 1 1973 26

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Comprehensive Guide to Diethyl Pyridine-2,3-Dicarboxylate (CAS No. 2050-22-8): Properties, Applications, and Industry Insights

Diethyl pyridine-2,3-dicarboxylate (CAS No. 2050-22-8) is a versatile organic compound widely used in pharmaceutical synthesis, agrochemical formulations, and material science. As a pyridine derivative, it serves as a critical building block for heterocyclic compounds, attracting significant attention from researchers and industrial chemists. This article delves into its molecular structure, synthesis methods, and emerging applications while addressing trending topics like green chemistry and sustainable synthesis—key concerns in modern chemical industries.

The compound’s systematic name, diethyl 2,3-pyridinedicarboxylate, reflects its ester-functionalized pyridine core. With a molecular formula of C₁₁H₁₁NO₄, it exhibits unique physicochemical properties, including a melting point range of 45–48°C and solubility in common organic solvents like ethanol and dichloromethane. These traits make it ideal for multistep organic synthesis, particularly in constructing nitrogen-containing heterocycles—a hot topic in drug discovery forums and patent literature.

Recent studies highlight its role in developing biodegradable polymers and photoactive materials, aligning with the global push for eco-friendly alternatives. A 2023 Journal of Organic Chemistry report demonstrated its utility in metal-organic frameworks (MOFs), addressing frequent search queries like "pyridine derivatives in nanotechnology". Furthermore, its low toxicity profile (as per OECD guidelines) positions it favorably compared to traditional halogenated intermediates, resonating with ESG-focused manufacturers.

In pharmaceutical contexts, diethyl pyridine-2,3-dicarboxylate acts as a precursor for anticancer agent scaffolds. Patent analyses reveal its incorporation in kinase inhibitor syntheses—a trending subject given the rise of targeted cancer therapies. Its chemodiversity also extends to agrochemicals, where it modifies pesticide photostability, answering common search terms like "pyridine esters in crop protection".

From a commercial perspective, the compound’s global market is projected to grow at 6.2% CAGR (2024–2030), driven by demand for high-performance specialty chemicals. Analytical techniques like HPLC purity testing (≥98%) and GC-MS characterization ensure quality compliance—frequently searched topics among quality control professionals. Storage recommendations emphasize inert atmospheres to prevent hydrolysis, a practical insight for laboratory handlers.

Innovative applications include its use in OLED materials, where its electron-accepting pyridine ring enhances electroluminescence efficiency. This connects with booming interest in flexible display technologies. Additionally, its derivatization into ionic liquids for battery electrolytes taps into the renewable energy discourse—a strategic alignment with current industry trends.

For researchers exploring structure-activity relationships (SAR), this compound offers modular functionalization sites at C-2 and C-3 carboxylates. Computational chemistry studies (e.g., DFT calculations) frequently reference its molecular orbitals—addressing technical queries like "pyridine dicarboxylate reactivity prediction". Such data-rich applications underscore its relevance in AI-driven drug design pipelines.

Environmental considerations are paramount; recent lifecycle assessments confirm its lower bioaccumulation potential versus aromatic hydrocarbons. Regulatory databases (e.g., REACH) list no major restrictions, though proper laboratory waste management protocols remain essential—an often-searched compliance topic.

In summary, diethyl pyridine-2,3-dicarboxylate (CAS 2050-22-8) bridges academic research and industrial innovation. Its adaptability across life sciences, advanced materials, and clean technology sectors ensures enduring relevance. As synthetic methodologies evolve toward catalyst-free reactions and flow chemistry, this compound’s utility spectrum will likely expand further.

• 136-45-8(MGK 326)
• 32413-08-4(Diethyl 2,3-quinolinedicarboxylate)
• 605-38-9(2,3-dimethyl pyridine-2,3-dicarboxylate)
• 17874-78-1(6-(ethoxycarbonyl)nicotinic Acid)
• 881-86-7(2,5-dimethyl pyridine-2,5-dicarboxylate)
• 5657-51-2(Furo3,4-BPyridin-5(7h)-One)
• 699-98-9(5H,7H-furo[3,4-b]pyridine-5,7-dione)
• 24195-07-1(2-(methoxycarbonyl)pyridine-3-carboxylic acid)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)