• 1. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 2. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 4. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrimidines Purines and purine derivatives

Recent Advances in the Study of 2,6-Dichloro-9-(propan-2-yl)-9H-purine (CAS: 203436-45-7)

The compound 2,6-dichloro-9-(propan-2-yl)-9H-purine (CAS: 203436-45-7) has garnered significant attention in the field of chemical biology and medicinal chemistry due to its versatile applications in drug discovery and development. This purine derivative serves as a key intermediate in the synthesis of various biologically active molecules, particularly in the development of kinase inhibitors and antiviral agents. Recent studies have explored its structural modifications and pharmacological properties, shedding light on its potential therapeutic uses.

One of the most notable advancements in the study of this compound is its role in the synthesis of adenosine receptor antagonists. Researchers have demonstrated that 2,6-dichloro-9-(propan-2-yl)-9H-purine can be efficiently converted into high-affinity ligands for adenosine A2A and A2B receptors, which are implicated in inflammatory diseases and cancer. A 2023 study published in the Journal of Medicinal Chemistry highlighted the compound's utility in generating selective A2A receptor antagonists with improved pharmacokinetic profiles.

In addition to its applications in receptor modulation, recent research has investigated the compound's potential as a scaffold for kinase inhibitors. A study conducted by a team at the University of Cambridge (2024) revealed that derivatives of 2,6-dichloro-9-(propan-2-yl)-9H-purine exhibit potent inhibitory activity against cyclin-dependent kinases (CDKs), which are critical targets in cancer therapy. The study employed structure-activity relationship (SAR) analysis to optimize the compound's selectivity and efficacy, resulting in promising preclinical candidates.

Another area of interest is the compound's role in antiviral drug development. A 2024 publication in Antiviral Research reported that 2,6-dichloro-9-(propan-2-yl)-9H-purine derivatives exhibit broad-spectrum activity against RNA viruses, including SARS-CoV-2 and influenza. The researchers attributed this activity to the compound's ability to interfere with viral RNA polymerase function, suggesting its potential as a lead compound for future antiviral therapies.

From a synthetic chemistry perspective, recent advancements have focused on improving the scalability and sustainability of 2,6-dichloro-9-(propan-2-yl)-9H-purine production. A 2023 study in Organic Process Research & Development introduced a novel catalytic method for its synthesis, reducing the reliance on hazardous reagents and improving overall yield. This development is particularly relevant for industrial-scale applications, where cost-effectiveness and environmental considerations are paramount.

In conclusion, the ongoing research on 2,6-dichloro-9-(propan-2-yl)-9H-purine (CAS: 203436-45-7) underscores its significance as a versatile building block in medicinal chemistry. Its applications span receptor modulation, kinase inhibition, and antiviral therapy, with recent studies highlighting both its pharmacological potential and synthetic accessibility. As the field progresses, further exploration of its derivatives and mechanisms of action will likely yield additional therapeutic candidates.

• 89981-46-4(6-chloro-9-propyl-9H-Purine)
• 1258274-92-8(6-chloro-7-(1-methylethyl)-7H-Purine)
• 244030-28-2(6-chloro-9-isopropyl-purin-2-amine)
• 23191-87-9(9H-Purine,9,9'-ethylenebis[6-chloro- (7CI,8CI))
• 6627-30-1(6-Chloro-9-cyclopropyl-9H-purine)
• 190655-14-2(2,6-dichloro-9-ethyl-9H-Purine)
• 190654-80-9(2,6-dichloro-7-ethyl-7H-Purine)
• 5462-86-2(6-chloro-9-ethyl-9H-purine)
• 2382-10-7(2,6-DICHLORO-9-METHYLPURINE)
• 500539-08-2(6-Chloro-9-isopropyl-9H-purine)