Cas no 203314-48-1 (2,5-Dichlorophenylacetyl Chloride)

2,5-Dichlorophenylacetyl chloride is a reactive organochlorine compound primarily used as an intermediate in organic synthesis. Its key structural features include a phenyl ring substituted with chlorine atoms at the 2- and 5-positions, along with an acetyl chloride functional group, making it a versatile building block for pharmaceuticals, agrochemicals, and specialty chemicals. The dichloro substitution enhances its reactivity in electrophilic aromatic substitution and acylation reactions. This compound is particularly valued for its role in synthesizing active pharmaceutical ingredients (APIs) and fine chemicals due to its high purity and consistent performance. Proper handling is essential due to its moisture sensitivity and corrosive nature.
2,5-Dichlorophenylacetyl Chloride structure
203314-48-1 structure
Product Name:2,5-Dichlorophenylacetyl Chloride
CAS No:203314-48-1
MF:C8H5Cl3O
MW:223.483699560165
MDL:MFCD08543437
CID:1396723
PubChem ID:26967735
Update Time:2025-05-19

2,5-Dichlorophenylacetyl Chloride Chemical and Physical Properties

Names and Identifiers

    • (2,5-Dichlorophenyl)acetyl chloride
    • 2,5-DICHLOROPHENYLACETYL CHLORIDE
    • Benzeneacetyl chloride, 2,5-dichloro-
    • 203314-48-1
    • 2-(2,5-dichlorophenyl)acetylchloride
    • PS-10928
    • 2-(2,5-dichlorophenyl)acetyl chloride
    • 2,5-Dichlorophenylacetyl chloride, AldrichCPR
    • AKOS027322467
    • MFCD08543437
    • 2,5-Dichlorophenylacetyl Chloride
    • MDL： MFCD08543437
    • Inchi： 1S/C8H5Cl3O/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3H,4H2
    • InChI Key： JMYRSGUMKCHSRO-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(=CC=1CC(=O)Cl)Cl

Computed Properties

  • Exact Mass: 221.940598g/mol
  • Monoisotopic Mass: 221.940598g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 2
  • Complexity: 172
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.6
  • Topological Polar Surface Area: 17.1?2

2,5-Dichlorophenylacetyl Chloride Security Information

  • Hazard Statement： Corrosive
  • Hazard Category Code： 22
  • Hazardous Material Identification： C Xn

2,5-Dichlorophenylacetyl Chloride Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Apollo Scientific
OR9377-1g
2,5-Dichlorophenylacetyl chloride
 203314-48-1
1g
 ￡96.00 2025-02-20
Apollo Scientific
OR9377-5g
2,5-Dichlorophenylacetyl chloride
 203314-48-1
5g
 ￡432.00 2025-02-20
TRC
D437700-50mg
2,5-Dichlorophenylacetyl Chloride
 203314-48-1
50mg
 $ 50.00 2022-06-05
TRC
D437700-100mg
2,5-Dichlorophenylacetyl Chloride
 203314-48-1
100mg
 $ 65.00 2022-06-05
TRC
D437700-500mg
2,5-Dichlorophenylacetyl Chloride
 203314-48-1
500mg
 $ 185.00 2022-06-05
abcr
AB248823-1 g
2,5-Dichlorophenylacetyl chloride
 203314-48-1
1g
 €200.20 2023-04-27
abcr
AB248823-5 g
2,5-Dichlorophenylacetyl chloride
 203314-48-1
5g
 €467.20 2023-04-27
abcr
AB248823-1g
2,5-Dichlorophenylacetyl chloride; .
 203314-48-1
1g
 €210.50 2025-02-14
abcr
AB248823-5g
2,5-Dichlorophenylacetyl chloride; .
 203314-48-1
5g
 €807.30 2025-02-14
Key Organics Ltd
PS-10928-5mg
2,5-Dichlorophenylacetyl chloride
 203314-48-1 >95%
5mg
 ￡46.00 2025-02-09

2,5-Dichlorophenylacetyl Chloride Related Literature

Related Categories

Additional information on 2,5-Dichlorophenylacetyl Chloride

Recent Advances in the Application of 2,5-Dichlorophenylacetyl Chloride (CAS 203314-48-1) in Chemical and Pharmaceutical Research

2,5-Dichlorophenylacetyl Chloride (CAS 203314-48-1) is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Recent studies have highlighted its significance in the development of novel bioactive compounds, particularly in the fields of antimicrobial and anticancer research. This research briefing aims to provide an overview of the latest advancements involving this compound, focusing on its synthetic applications, mechanistic insights, and potential therapeutic benefits.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers utilized 2,5-Dichlorophenylacetyl Chloride as a precursor for the synthesis of a new class of antimicrobial agents. The study demonstrated that derivatives of this compound exhibited potent activity against multidrug-resistant bacterial strains, including MRSA and Pseudomonas aeruginosa. The mechanism of action was linked to the inhibition of bacterial cell wall synthesis, making these derivatives promising candidates for further development.

Another significant application of 2,5-Dichlorophenylacetyl Chloride was reported in a recent Nature Communications article, where it was used to synthesize small-molecule inhibitors targeting specific oncogenic pathways. The study revealed that these inhibitors effectively suppressed tumor growth in preclinical models of breast and lung cancer, with minimal off-target effects. The researchers attributed this selectivity to the unique structural properties imparted by the 2,5-dichlorophenyl moiety.

From a synthetic chemistry perspective, advancements in the efficient production of 2,5-Dichlorophenylacetyl Chloride have also been achieved. A 2024 paper in Organic Process Research & Development described a novel catalytic method that significantly reduces the environmental impact of its synthesis. This method employs greener solvents and catalysts, aligning with the growing emphasis on sustainable chemical processes in the pharmaceutical industry.

In conclusion, 2,5-Dichlorophenylacetyl Chloride (CAS 203314-48-1) continues to play a pivotal role in chemical and pharmaceutical research. Its versatility as a building block for bioactive compounds, coupled with recent innovations in its synthesis and application, underscores its importance in addressing pressing medical challenges. Future research directions may include further optimization of its derivatives for enhanced efficacy and safety profiles, as well as exploration of its potential in other therapeutic areas.

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